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Fig. 1 | BMC Genetics

Fig. 1

From: An RGS2 3′UTR polymorphism is associated with preeclampsia in overweight women

Fig. 1

The role of the regulator of G-protein signaling 2 (RGS2) protein in vasoconstriction. Vasoconstrictive ligands, such as angiotensin II (AT II), vasopressin (ADH) and norepinephrine (NE), bind to their specific G-protein coupled receptors angiotensin II receptor type 1 (ATR1), vasopressin receptor 1A (AVPR1A) and α1-adrenergic receptor (α1) located in vascular smooth muscle cells. This leads to dissociation of the active subunits of the receptor and activation of the downstream effectors promoting vasoconstriction. The RGS2 protein enhances GTP hydrolysis in the Gα subunit inhibiting the dissociation of the subunits and therefore inhibiting vasoconstriction

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