An RGS2 3′UTR polymorphism is associated with preeclampsia in overweight women

BMC Genomic Data

Table 2 Association of the RGS2 rs4606 genotypes with all preeclampsia patients and in groups divided by BMI

BMI category		n^a	CC	GG or CG	OR (95 % CI)	P
All	Preeclampsia	1324	780 (58.9)	544 (41.1)	1.109 (0.919–1.338)	0.282
All	Control	694	426 (61.4)	268 (38.6)	1.109 (0.919–1.338)	0.282
Normal weight (BMI < 25 kg/m²)	Preeclampsia	784	484 (61.7)	300 (38.3)	0.971 (0.769–1.226)	0.806
Normal weight (BMI < 25 kg/m²)	Control	480	293 (61.0)	187 (39.0)	0.971 (0.769–1.226)	0.806
Overweight (BMI ≥ 25 kg/m² and < 30 kg/m²)	Preeclampsia	310	162 (52.3)	148 (47.7)	1.635 (1.103–2.423)	0.014
Overweight (BMI ≥ 25 kg/m² and < 30 kg/m²)	Control	159	102 (64.2)	57 (35.8)	1.635 (1.103–2.423)	0.014
Obese (BMI ≥ 30 kg/m²)	Preeclampsia	227	133 (58.6)	94 (41.4)	0.913 (0.504–1.655)	0.764
Obese (BMI ≥ 30 kg/m²)	Control	55	31 (56.4)	24 (43.6)	0.913 (0.504–1.655)	0.764

Binary logistic regression: preeclampsia patients vs control subjects, dominant model. Number of subjects and frequencies (%) are presented. OR indicates odds ratio, CI confidence interval and BMI body mass index. ^aAltogether 1324 preeclamptic and 694 non-preeclamptic women were successfully genotyped. BMI information was missing for 3 preeclamptic cases (1 CC and 2 CG genotypes)

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