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Fig. 3 | BMC Genetics

Fig. 3

From: Genome sequencing reveals a splice donor site mutation in the SNX14 gene associated with a novel cerebellar cortical degeneration in the Hungarian Vizsla dog breed

Fig. 3

Cerebellar Purkinje neuron degeneration in an affected HV case (Case 2). Higher magnification of the cerebellar cortex in an affected HV (a and b) reveals shrunken, angular and eosinophilic (degenerate) Purkinje neurons (arrows). Reduced cellularity of the granular cell layer (G) and thinning and pallor of the molecular cell layer (M) are also evident, compared to the densely populated granular cell layer and normal molecular cell layer in the unaffected control dog (c). (Haematoxylin and eosin stain, ×200 magnification)

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