Skip to main content

Table 5 Main characteristics of individual studies included in the meta-analysis on ABCB1 C3435T polymorphism and breast cancer risk

From: Association between ABCB1 C3435T polymorphism and breast cancer risk: a Moroccan case-control study and meta-analysis

Study Country Ethnicity Sample size (N Cases/ N controls) Genotyping method Cases Controls HWE*
Genotypes (N) Alleles (N) Genotypes (N) Alleles (N)
CC CT TT C T CC CT TT C T
Tazzite et al. 2016 (current paper) Morocco North Africa 60/68 PCR-RFLP 30 20 10 80 40 28 33 7 89 47 0.55
Abuhaliema et al. 2016 [26] Jordan Middle East 150/150 PCR-RFLP 68 62 20 198 102 40 65 45 145 155 0.11
Ghafouri et al. 2015 Iran Caucasian 100/200 PCR-RFLP 75 16 9 166 34 141 50 9 332 68 0.11
Gutierrez-Rubio et al. 2015 [24] Mexico Mixed 248/152 PCR-RFLP 82 133 33 297 199 56 72 24 184 120 0.91
Macías-Gómez et al. 2014 [23] Mexico Mixed 64/183 PCR-RFLP 15 41 8 71 57 37 103 43 177 189 0.09
Fawzy et al. 2014 [22] Egypt North Africa 190/190 ARMS-PCR 60 92 38 212 168 76 94 20 246 134 0.25
Rubis et al. 2012 [21] Poland Caucasian 209/205 PCR-RFLP 48 96 65 192 226 52 103 50 207 203 0.94
Wu et al. 2012 [20] China Asian 1,173/1,244 PCR-RFLP 388 565 220 1,341 1,005 440 624 180 1,504 984 0.08
Abbas et al. 2010 [19] Germany Caucasian 3,148/5,486 MALDI-TOF MS 703 1,543 902 2,949 3,347 1,228 2,736 1,522 5,192 5,780 0.98
Taheri et al. 2010 [18] Iran Caucasian 54/50 PCR-RFLP 10 30 14 50 58 10 27 13 47 53 0.55
Cizmarikova et al. 2010 [17] Slovak Caucasian 221/113 PCR-RFLP 46 108 67 200 242 35 54 24 124 102 0.71
Tatari et al. 2009 [16] Iran Caucasian 106/77 PCR-RFLP 16 57 33 89 123 12 45 20 69 85 0.11
George et al. 2009 [15] India Asian 86/68 PCR-RFLP 8 39 39 55 117 15 32 21 62 74 0.67
Henriquez-Hernandez et al. 2009 [14] Spain Caucasian 135/301 PCR-RFLP 35 70 30 140 130 85 162 54 332 270 0.13
Turgut et al. 2007 [13] Turkey Caucasian 57/50 PCR-RFLP 7 33 17 47 67 18 23 9 59 41 0.73
Nordgard et al. 2007 [12] Norway Caucasian 93/109 PCR-RFLP 9 51 33 69 117 17 52 40 86 132 0.99
  1. N number, CC homozygous wild-type, CT heterozygous, TT homozygous mutant, PCR-RFLP Polymerase chain reaction-restriction fragment length polymorphism, ARMS-PCR Amplification refractory mutation system-polymerase chain reaction, MALDI-TOF MS Matrix assisted laser desorption/ionization time-of-flight mass spectrometry, HWE Hardy Weinberg equilibrium; *P value in the control group