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Table 7 Stratified analysis based on ethnicity for the association between ABCB1 C3435T polymorphism and breast cancer risk

From: Association between ABCB1 C3435T polymorphism and breast cancer risk: a Moroccan case-control study and meta-analysis

Ethnicity Cases/ controls Recessive model
TT vs. CC + CT
Dominant model
CC vs. TT + CT
Homozygote model
TT vs. CC
Allele contrast model
T vs. C
OR (95 % CI); P value Ph OR (95 % CI); P value Ph OR (95 % CI); P value Ph OR (95 % CI); P value Ph
Fixed effects Random effects Fixed effects Random effects Fixed effects Random effects Fixed effects Random effects
Asian 4,835/7,334 1.405 (1.145 to 1.725) ; 0.001 1.405 (1.144 to 1.725) ; 0.001 0.3888 0.876 (0.742 to 1.033) ; 0.116 0.644 (0.271 to 1.528) ; 0.318 0.0573 1.458 1.156 to 1.840) ; 0.001 1.918 (0.809 to 4.545) ; 0.139 0.0816 1.175 (1.051 to 1.313) ; 0.005 1.346 (0.887 to 2.042) ; 0.163 0.0706
Caucasian 4,123/6,591 1.093 (1.001 to 1.194) ; 0.048 1.124 (1.002 to 1.262) ; 0.047 0.3993 0.954 (0.869 to 1.049) ; 0.333 0.844 (0.677 to 1.052) ; 0.131 0.0857 1.119 (1.000 to 1.252) ; 0.050 1.427 (1.079 to 1.886) ; 0.013 0.0836 1.054 (0.996 to 1.114) ; 0.068 1.147 (1.014 to 1.298) ; 0.030 0.1382
Mixed 312/335 0.666 (0.422 to 1.054) ; 0.083 0.667 (0.391 to 1.138) ; 0.137 0.2640 0.933 (0.651 to 1.339) ; 0.708 0.935 (0.653 to 1.338) ; 0.712 0.3854 0.755 (0.449 to 1.269) ; 0.289 0.724 (0.368 to 1.422) ; 0.348 0.2221 0.923 (0.729 to 1.169) ; 0.506 0.908 (0.673 to 1.225) ; 0.528 0.2197
North Africa 250/258 2.028 (1.220 to 3.371) ; 0.006 2.026 (1.218 to 3.369) ; 0.007 0.7438 0.841 (0.587 to 1.204) ; 0.343 0.940 (0.466 to 1.896) ; 0.864 0.0822 2.072 (1.196 to 3.590) ; 0.009 2.072 (1.193 to 3.596) ; 0.010 0.3610 1.312 (1.018 to 1.690) ; 0.036 1.241 (0.826 to 1.863) ; 0.298 0.1572
  1. Values in italic are statistically significant (P value <0.05); Random effects model was used when Ph < 0.05 otherwise fixed effects model was used
  2. CC homozygous wild-type, CT heterozygous, TT homozygous mutant, OR Odd Ratio, CI Confidence Interval; Ph: P value of Q test for heterogeneity test