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Table 3 Genes differentially expressed in ISIAH versus WAG renal medulla and annotated in Rat Genome Database as associated with kidney diseases

From: The gene-expression profile of renal medulla in ISIAH rats with inherited stress-induced arterial hypertension

Gene symbol NCBI gene ID Gene name log2 fold change ISIAH/WAG
Acsm3 24763 acyl-CoA synthetase medium-chain family member 3 3.40
Adipoq c,d 246253 adiponectin, C1Q and collagen domain containing 1.17
Agtr1a a,c,d 24180 angiotensin II receptor, type 1a −0.47
Ak4 c 29223 adenylate kinase 4 0.63
Alpl 25586 alkaline phosphatase, liver/bone/kidney 0.53
Amacr 25284 alpha-methylacyl-CoA racemase 0.50
Angpt2 a 89805 angiopoietin 2 −0.79
Anxa2 56611 annexin A2 −0.45
Apoh d 287774 apolipoprotein H (beta-2-glycoprotein I) −1.52
Aqp2 d 25386 aquaporin 2 (collecting duct) −0.47
Baat 29725 bile acid CoA: amino acid N-acyltransferase (glycine N-choloyltransferase) 0.78
Car2 54231 carbonic anhydrase 2 0.53
Cftr 24255 cystic fibrosis transmembrane conductance regulator −1.22
Cldn19 298487 claudin 19 −0.53
Clu a,c,d 24854 clusterin −0.80
Col3a1 a,c 84032 collagen, type III, alpha 1 −0.64
Col4a5 363457 collagen, type IV, alpha 5 −0.45
Comt 24267 catechol-O-methyltransferase −0.67
Csf1r c,d 307403 colony stimulating factor 1 receptor −0.73
Cst3 d 25307 cystatin C −0.50
Cubn d 80848 cubilin (intrinsic factor-cobalamin receptor) 0.68
Cyp1a1 c 24296 cytochrome P450, family 1, subfamily a, polypeptide 1 −0.51
Cyp4a3 298423 cytochrome P450, family 4, subfamily a, polypeptide 3 0.52
Dusp1 114856 dual specificity phosphatase 1 −0.71
Ebag9 299864 estrogen receptor binding site associated, antigen, 9 0.49
Ephx2 c,d 65030 epoxide hydrolase 2, cytoplasmic 4.52
F2 c,d 29251 coagulation factor II −0.93
Fbn1 a,d 83727 fibrillin 1 −0.61
Fga c 361969 fibrinogen alpha chain 0.85
Fhit 60398 fragile histidine triad 1.58
Fmod d 64507 fibromodulin −1.09
Fn1 a,c,d 25661 fibronectin 1 −0.98
Gatm c 81660 glycine amidinotransferase (L-arginine:glycine amidinotransferase) 0.86
Gja1 24392 gap junction protein, alpha 1 0.99
Gpc1 58920 glypican 1 −0.72
Gstp1 c 24426 glutathione S-transferase pi 1 0.53
Gtpbp4 c 114300 GTP binding protein 4 3.01
Hao1 311446 hydroxyacid oxidase (glycolate oxidase) 1 −1.60
Hgf d 24446 hepatocyte growth factor −0.77
Igf1 d 24482 insulin-like growth factor 1 −0.75
Igfbp1 d 25685 insulin-like growth factor binding protein 1 1.26
Il4r 25084 interleukin 4 receptor 0.64
Lama2 309368 laminin, alpha 2 −0.58
Lgals1 56646 lectin, galactoside-binding, soluble, 1 0.88
Lrp1 a 299858 low density lipoprotein receptor-related protein 1 −0.53
Lrp5 293649 low density lipoprotein receptor-related protein 5 −0.47
Ltbp1 59107 latent transforming growth factor beta binding protein 1 −0.57
Mif 81683 macrophage migration inhibitory factor (glycosylation-inhibiting factor) 0.55
Mme 24590 membrane metallo-endopeptidase 1.35
Mmp2 a, c 81686 matrix metallopeptidase 2 −0.54
Mmp9 a, d 81687 matrix metallopeptidase 9 −2.00
Mok 362787 MOK protein kinase −0.93
Mthfr b, c, d 362657 methylenetetrahydrofolate reductase (NAD(P)H) 0.49
Nos3 c, d 24600 nitric oxide synthase 3, endothelial cell −0.55
Nox4 d 85431 NADPH oxidase 4 0.50
Nphs2 a 170672 nephrosis 2, idiopathic, steroid-resistant 0.57
Pecam1 d 29583 platelet/endothelial cell adhesion molecule 1 −0.45
Pla2g4a 24653 phospholipase A2, group IVA (cytosolic, calcium-dependent) −0.69
Ptgds b, d 25526 prostaglandin D2 synthase (brain) −0.78
Ptk2b 50646 protein tyrosine kinase 2 beta −0.79
Rap1gap a 313644 Rap1 GTPase-activating protein −0.60
Retn c, d 246250 resistin expression was detected only in ISIAH rats
RT1-Bb 309622 RT1 class II, locus Bb −1.26
Serpinf1 d 287526 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1 −2.10
Serping1 295703 serpin peptidase inhibitor, clade G (C1 inhibitor), member 1 0.56
Sfrp1 84402 secreted frizzled-related protein 1 −0.61
Slc17a2 306950 solute carrier family 17, member 2 0.59
Slc19a3 c 316559 solute carrier family 19 (thiamine transporter), member 3 1.00
Slc5a2 64522 solute carrier family 5 (sodium/glucose cotransporter), member 2 0.64
Slc6a19 664630 solute carrier family 6 (neutral amino acid transporter), member 19 0.48
Slit2 360272 slit homolog 2 (Drosophila) 0.45
Sod3 d 25352 superoxide dismutase 3, extracellular 0.56
Tf d 24825 transferrin −1.43
Timp2 d 29543 TIMP metallopeptidase inhibitor 2 −0.52
Vcam1 c,d 25361 vascular cell adhesion molecule 1 −0.86
Vtn d 29169 vitronectin −1.18
  1. Genes associated with: arenal fibrosis; bnephrosclerosis; crenal insufficiency, ddiabetic nephropathy; ISIAH and WAG – rat strains used in the study