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Table 2 Overrepresented (BH adjusted p-value < 0.05) GO terms (biological processes, molecular functions, cellular compartments) that characterize functional groups of genes presented in Fig. 2b.

From: A compendium of human genes regulating feeding behavior and body weight, its functional characterization and identification of GWAS genes involved in brain-specific PPI network

Functional group

GO category

GO class

Number of genes from the compendium annotated by the category

Fold Enrichment

BH adjusted p-value

Transmembrane receptors

GO:0004888 ~transmembrane receptor activity

Molecular function

89

2.09

1.6E-09

Transcription factors

GO:0003700 ~ transcription factor activity

Molecular function

52

1.63

1.1E-02

Signaling molecules (hormones, neuropeptides, cytokines, etc.)

GO:0005179 ~ hormone activity

Molecular function

37

10.48

1.5E-24

GO:0005184 ~ neuropeptide hormone activity

Molecular function

15

19.95

7.6E-14

GO:0005125 ~ cytokine activity

Molecular function

16

2.51

3.2E-02

Signal transduction

GO:0004871 ~ signal transducer activity

Molecular function

139

1.87

3.2E-12

Cilium or BBSome

GO:0060271 ~ cilium morphogenesis

Biological process

10

8.77

1.5E-05

GO:0034464 ~ BBSome

Cellular component

7

31.56

1.8E-07

Lipid localization

GO:0008289 ~ lipid binding

Molecular function

34

2.31

3.9E-04

Transcriptional coregulators

Nonea

Enzymes (regulatory)

None

Enzymes (metabolic)

None

  1. The list of 578 genes from the compendium was analyzed with the DAVID-tool. The significance level for the BH adjusted p-value was 0.05
  2. aNone – No overrepresented GO terms were found