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Table 3 Characterization of three networks formed by associations between genes/proteins from the compendium

From: A compendium of human genes regulating feeding behavior and body weight, its functional characterization and identification of GWAS genes involved in brain-specific PPI network

Network/Association type

Number of nodes (genes/proteins)/Number of genes as a percentage of all genes from the compendium

Number of edges

Average number of neighbors

Genes with the highest numbers of neighbors

Experimental

355 (62%)

1254

4.3

ESR1, SIRT1, AR, NFKB1, STAT3, MAPK3, HDAC3, UBB, PTPN11

Knowledge

304 (53%)

2403

15.9

AGT, KNG1, MCHR1, PMCH, NMUR2, NMUR1, NMS, NMU, MCHR2, POMC

Homology

142 (25%)

522

7.4

NMUR2, NMUR1, MCHR1, MCHR2, OPRD1, NPY1R

All three types

The total number of genes involved in all three networks = 408 (71%)