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Table 2 Association results of epilepsy and the ADAM23 risk haplotypea in eight dog breeds

From: ADAM23 is a common risk gene for canine idiopathic epilepsy

Breed

N cases/controls

Risk haplo cases freq

Risk haplo control freq

p-value

OR (95% C.I.)

Risk haplo homozygosity cases freq

Risk haplo homozygosity controls freq

p-value

OR (95% C.I.)

Cases/controls without risk haplotype

Australian Shepherd 59/71

0.66

0.52

0.03

1.8 (1.1–3.0)

0.46

0.32

0.11

1.8 (0.9–3.6)

14%/28%

Finnish Lapphund 35/50

0.46

0.50

0.58

0.8 (0.5–1.6)

na

na

na

na

na

Irish Setter (red) 19/36

0.97

0.90

0.17

4.0 (0.5–33.7)

0.95

0.83

0.22

3.6 (0.4–32.4)

0%/3%

Kromfohrländer 46/29

0.88

0.69

0.004

3.2 (1.4–7.7)

0.83

0.45

0.0008

5.5 (1.9–16.8)

7%/7%

Labrador Retriever 29/50

0.59

0.33

0.003

2.9 (1.5–5.6)

0.34

0.16

0.06

2.8 (0.9–8.1)

17%/50%

Miniature Pinscher 16/15

0.88

0.7

0.05

3.3 (0.9–14.0)

0.75

0.53

0.21

2.5 (0.5–13.0)

0%/13%

Pyrenean Shepherd 17/23

0.65

0.43

0.06

2.3 (0.9–6.0)

0.47

0.13

0.02

5.5 (1.2–31.8)

18%/26%

Whippet 17/25

0.94

0.58

0.0002

11.3 (2.9–81.5)

0.89

0.36

0.0005

12.6 (2.7–102.3)

0%/20%

  1. P-values <0.05 are bolded
  2. OR odds ratio, C.I. confidence interval, na not analysed
  3. aHaplotype T-C-del-del-G-G at 15,085,438 (BICF2S23030950), 15,106,446 (BICF2P1021781), 15,108,593, 15,108,802, 15,111,724 (BICF2P1131874) and 15,113,325 bp in ADAM23 (~28 kb), respectively (CanFam3.1)