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Table 2 Association results of epilepsy and the ADAM23 risk haplotypea in eight dog breeds

From: ADAM23 is a common risk gene for canine idiopathic epilepsy

Breed
N cases/controls
Risk haplo cases freq Risk haplo control freq p-value OR (95% C.I.) Risk haplo homozygosity cases freq Risk haplo homozygosity controls freq p-value OR (95% C.I.) Cases/controls without risk haplotype
Australian Shepherd 59/71 0.66 0.52 0.03 1.8 (1.1–3.0) 0.46 0.32 0.11 1.8 (0.9–3.6) 14%/28%
Finnish Lapphund 35/50 0.46 0.50 0.58 0.8 (0.5–1.6) na na na na na
Irish Setter (red) 19/36 0.97 0.90 0.17 4.0 (0.5–33.7) 0.95 0.83 0.22 3.6 (0.4–32.4) 0%/3%
Kromfohrländer 46/29 0.88 0.69 0.004 3.2 (1.4–7.7) 0.83 0.45 0.0008 5.5 (1.9–16.8) 7%/7%
Labrador Retriever 29/50 0.59 0.33 0.003 2.9 (1.5–5.6) 0.34 0.16 0.06 2.8 (0.9–8.1) 17%/50%
Miniature Pinscher 16/15 0.88 0.7 0.05 3.3 (0.9–14.0) 0.75 0.53 0.21 2.5 (0.5–13.0) 0%/13%
Pyrenean Shepherd 17/23 0.65 0.43 0.06 2.3 (0.9–6.0) 0.47 0.13 0.02 5.5 (1.2–31.8) 18%/26%
Whippet 17/25 0.94 0.58 0.0002 11.3 (2.9–81.5) 0.89 0.36 0.0005 12.6 (2.7–102.3) 0%/20%
  1. P-values <0.05 are bolded
  2. OR odds ratio, C.I. confidence interval, na not analysed
  3. aHaplotype T-C-del-del-G-G at 15,085,438 (BICF2S23030950), 15,106,446 (BICF2P1021781), 15,108,593, 15,108,802, 15,111,724 (BICF2P1131874) and 15,113,325 bp in ADAM23 (~28 kb), respectively (CanFam3.1)