Table 4 Power of GRM and CAT tests to detect association for a P-value threshold of 1.0E-7 using a sample size of 1000 cases/1000 controls
Simulated model: Additive | Simulated model: Dominant | Simulated model: Recessive | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Tests: | Tests: | Tests: | |||||||||||
MAF | OR | CAT_DOM | CAT_REC | CAT_ADD | GRM | CAT_DOM | CAT_REC | CAT_ADD | GRM | CAT_DOM | CAT_REC | CAT_ADD | GRM |
0.1 | 1.2 | 0 | 0 | 0 | 0.00 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
0.1 | 1.4 | 0.03 | 0 | 0.04 | 0.02 | 0.02 | 0 | 0.02 | 0.01 | 0 | 0 | 0 | 0 |
0.1 | 1.6 | 0.36 | 0 | 0.42 | 0.27 | 0.25 | 0 | 0.21 | 0.16 | 0 | 0 | 0 | 0 |
0.1 | 1.8 | 0.85 | 0 | 0.89 | 0.80 | 0.72 | 0 | 0.66 | 0.60 | 0 | 0 | 0 | 0 |
0.1 | 2 | 0.99 | 0.03 | 1 | 0.99 | 0.96 | 0 | 0.94 | 0.92 | 0 | 0 | 0 | 0 |
0.1 | 2.2 | 1 | 0.14 | 1 | 1 | 1 | 0 | 0.99 | 0.99 | 0 | 0 | 0 | 0 |
0.1 | 2.4 | 1 | 0.38 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 |
0.1 | 2.6 | 1 | 0.67 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 |
0.1 | 2.8 | 1 | 0.88 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 |
0.1 | 3 | 0.99 | 0.96 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 0.01 | 0 | 0 |
0.1 | 3.2 | 0.99 | 0.99 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 0.02 | 0 | 0 |
0.2 | 1.2 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
0.2 | 1.4 | 0.17 | 0 | 0.26 | 0.17 | 0.07 | 0 | 0.04 | 0.04 | 0 | 0 | 0 | 0 |
0.2 | 1.6 | 0.81 | 0.10 | 0.91 | 0.84 | 0.54 | 0 | 0.41 | 0.43 | 0 | 0 | 0 | 0 |
0.2 | 1.8 | 0.99 | 0.50 | 1 | 1 | 0.93 | 0 | 0.85 | 0.88 | 0 | 0.01 | 0 | 0 |
0.2 | 2 | 1 | 0.88 | 1 | 1 | 1 | 0 | 0.99 | 0.99 | 0 | 0.05 | 0 | 0.01 |
0.2 | 2.2 | 1 | 0.99 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 0.14 | 0.01 | 0.05 |
0.2 | 2.4 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 0.33 | 0.02 | 0.15 |
0.2 | 2.6 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 0.55 | 0.04 | 0.33 |
0.2 | 2.8 | 1 | 1 | 1 | 1 | 1 | 0.01 | 1 | 1 | 0 | 0.75 | 0.10 | 0.54 |
0.2 | 3 | 1 | 1 | 1 | 1 | 1 | 0.01 | 1 | 1 | 0 | 0.89 | 0.18 | 0.74 |
0.2 | 3.2 | 1 | 1 | 1 | 1 | 1 | 0.01 | 1 | 1 | 0 | 0.96 | 0.29 | 0.88 |
0.3 | 1.2 | 0 | 0 | 0.01 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
0.3 | 1.4 | 0.27 | 0.05 | 0.48 | 0.36 | 0.08 | 0 | 0.04 | 0.05 | 0 | 0 | 0 | 0 |
0.3 | 1.6 | 0.90 | 0.52 | 0.98 | 0.96 | 0.55 | 0 | 0.33 | 0.44 | 0 | 0.03 | 0 | 0.01 |
0.3 | 1.8 | 1 | 0.94 | 1 | 1 | 0.93 | 0 | 0.77 | 0.88 | 0 | 0.18 | 0.02 | 0.10 |
0.3 | 2 | 1 | 1 | 1 | 1 | 1 | 0 | 0.96 | 0.99 | 0 | 0.51 | 0.08 | 0.36 |
0.3 | 2.2 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 0.81 | 0.23 | 0.69 |
0.3 | 2.4 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 0.96 | 0.46 | 0.91 |
0.3 | 2.6 | 1 | 1 | 1 | 1 | 1 | 0.01 | 1 | 1 | 0.01 | 0.99 | 0.70 | 0.98 |
0.3 | 2.8 | 1 | 1 | 1 | 1 | 1 | 0.01 | 1 | 1 | 0.02 | 1 | 0.87 | 1 |
0.3 | 3 | 1 | 1 | 1 | 1 | 1 | 0.02 | 1 | 1 | 0.04 | 1 | 0.95 | 1 |
0.3 | 3.2 | 1 | 1 | 1 | 1 | 1 | 0.03 | 1 | 1 | 0.07 | 1 | 0.99 | 1 |
0.4 | 1.2 | 0 | 0 | 0.01 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
0.4 | 1.4 | 0.26 | 0.16 | 0.58 | 0.47 | 0.05 | 0 | 0.01 | 0.03 | 0 | 0.01 | 0 | 0 |
0.4 | 1.6 | 0.88 | 0.80 | 0.99 | 0.98 | 0.40 | 0 | 0.16 | 0.30 | 0 | 0.17 | 0.03 | 0.10 |
0.4 | 1.8 | 1 | 0.99 | 1 | 1 | 0.83 | 0 | 0.49 | 0.74 | 0 | 0.59 | 0.18 | 0.47 |
0.4 | 2 | 1 | 1 | 1 | 1 | 0.98 | 0 | 0.79 | 0.95 | 0 | 0.91 | 0.50 | 0.85 |
0.4 | 2.2 | 1 | 1 | 1 | 1 | 1 | 0 | 0.94 | 0.99 | 0.01 | 0.99 | 0.80 | 0.98 |
0.4 | 2.4 | 1 | 1 | 1 | 1 | 1 | 0 | 0.99 | 1 | 0.02 | 1 | 0.95 | 1 |
0.4 | 2.6 | 1 | 1 | 1 | 1 | 1 | 0.01 | 1 | 1 | 0.05 | 1 | 0.99 | 1 |
0.4 | 2.8 | 1 | 1 | 1 | 1 | 1 | 0.01 | 1 | 1 | 0.10 | 1 | 1 | 1 |
0.4 | 3 | 1 | 1 | 1 | 1 | 1 | 0.01 | 1 | 1 | 0.18 | 1 | 1 | 1 |