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Fig. 3 | BMC Genetics

Fig. 3

From: Detection of gene-environment interactions in the presence of linkage disequilibrium and noise by using genetic risk scores with internal weights from elastic net regression

Fig. 3

Power/type I error of weighted/unweighted GRS with increasing number of correlated SNPs. Power and Type I error comparison for the combined analysis of interaction effects between 6 SNPs and a single continuous environmental exposure. Comparison of continuous weighted GRS with weights from the elastic net regression with varying penalty weight α (α = 0.01, 0.05, 0.1, 0.15, 0.2, 0.3, 0.4, 0.5, 0.75, and 1; called EN001, EN005, …, EN1) and continuous unweighted GRS in different scenarios with increasing effect size of the interaction term (a) Mean OR(GxE) = 1.04 (n = 700), b) Mean OR(GxE) = 1.05 (n = 400)) and an increasing number of correlated SNPs that are in a high Linkage Disequilibrium with the 6 SNPs from Design 1 (from 42 to 210) (100 replications)

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