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Fig. 2 | BMC Genetics

Fig. 2

From: The relation between DNA methylation patterns and serum cytokine levels in community-dwelling adults: a preliminary study

Fig. 2

Associations between genome-wide DNA methylation patterns, partitioned using principal component analysis, and age group, sex and serum cytokine levels. Tests were performed by linear regression against the scores for the first 11 principal components. a) Natural-log (Ln) transformed serum cytokines were each tested in independent models that also adjusted for age group (middle-aged or elderly) and sex, and b) age group and sex were tested together in a single model without serum cytokines. Principal component (PC) 1 represented 22% of the overall DNA methylation variance, PC2 represented 12%, PC3 to PC10 represented between 9.9 and 5.2%, and PC11 represented 1.5%. Significance indicated by colour: dark blue, p < 0.05; light blue, p < 0.10; grey, p > 0.10

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