Fig. 3
Related functions of differentially expressed genes (DEGs). a. Expression patterns of DEGs by main functional clusters and tissue type for OHIGH-FHIGH treatment group. DEGs in stimulus response related clusters show a clear up-regulation trend; DGEs related to nutrient metabolism in the liver and DGEs related to muscle contraction and cellular respiration in the heart exhibit a clear broad-scale down-regulation. The numbers in each bar are numbers of genes. b. The positions of two core genes, ACTC1 and TNNC1, within the cardiac contraction pathway, and their expression levels in the four treatment groups