Association between serotonin transporter gene polymorphisms and increased suicidal risk among HIV positive patients in Uganda

Table 4 Association between the 5-HTTLPR, rs25531 and STin2. VNTR and increased suicidal risk

Polymorphism/ allele	Suicide risk categories
	No Bonferroni correction (α = 0.05)		With Bonferroni correction (α =0.0056)
	Genotype	Allelic	Genotype	Allelic
STin2.VNTRs		*0.0285		0.0285
5-HTTLPR		*0.0174		0.0174
rs25531		0.6125		0.6125
5-HTTLPR-rs25531	0.0732		0.0732
L _A		*0.0068		0.0068
S _A		*0.0046		*0.0046
L _G		0.3491		0.3491
S _G		0.5686		0.5686
Func_Comb	*0.0145		0.0145

p values were corrected for study site, socio-economic status and major depressive disorder
*Significant effect, Func_Comb = Functional combination (over expressing (L _A, S _A) vs lower expressing (L _G, S _G alleles). The STin2.VNTRs, serotonin transporter intron 2 variable number of tandem repeats, rs25531, A to G single nucleotide polymorphism at position 25,531 of the serotonin transporter gene, 5-HTTLPR-rs25531, Serotonin transporter linked polymorphic region –rs25531 haplotype

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