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Table 3 Carrier rates by genetic ancestry

From: Evaluating genetic ancestry and self-reported ethnicity in the context of carrier screening

Sickle Cell Anemia
  carrier rate < threshold carrier rate > threshold p-value African Ancestry Threshold (80th percentile)
African 6.760% 15.741% 0.00605 93.439%
Latin American 1.261% 4.587% 0.00372 18.677%
Cystic Fibrosis
  carrier rate < threshold carrier rate > threshold p-value European Ancestry Threshold (80th percentile)
African 1.631% 6.482% 0.01095 19.928%
Latin American 1.606% 3.670% 0.06128 68.715%
GJB2-Related Nonsyndromic Hearing Loss
  carrier rate < threshold carrier rate > threshold p-value European Ancestry Threshold (80th percentile)
African 1.399% 5.556% 0.01870 19.928%
Latin American 3.440% 3.670% 0.83750 68.715%
  1. Differences in carrier rates of sickle sell anemia, cystic fibrosis, and GJB2-related nonsyndromic hearing loss by proportion of African and European ancestry among self-reported Africans and Latin Americans. For each group, an ancestry threshold was chosen by computing the 80th percentile of ancestry proportion. For example the 80th percentile of African ancestry among Latin Americans is 18.68%. Thus, the carrier rate of sickle cell anemia of Latin Americans below this threshold is 1.261% and the carrier rate above it is 4.587%. P-values were computed using Fisher’s exact test