Table 3 Top ten targeter TFs for Human (that are connected with maximum number of gene-modules and that regulate maximum number of genes from the connected gene-modules) with information of their maximum number of regulated genes as well as gene-modules, and verified information of them
SL. No | TFs | Number of connected gene-modules | Number of regulated genes | Name of the connected gene-modules (number of regulated genes in the modules) | Disease and Disease-verified information of TFs | Status of TFs |
|---|---|---|---|---|---|---|
1 | WHSC1 | 3 | 9 | Blue (4), Brown (2), Turquoise (3). | wolf Hirschhorn syndrome [31] | Known |
2 | E2F4 | 3 | 7 | Blue (4), Brown (2), Turquoise (1). | Neuro degeneration disorder [32] | Known |
3 | EPAS1 | 3 | 5 | Blue (2), Brown (2), Turquoise (1). | Iron toxicity effected the aging of brain [33] | Known |
4 | LBX1 | 3 | 5 | Blue (2), Brown (2), Turquoise (1). | Septo optic Dysplasia [73] | Known |
5 | MYST3 | 3 | 5 | Blue (2), Brown (2), Turquoise (1). | Â | Unknown |
6 | ZNF771 | 3 | 4 | Blue (2), Brown (1), Turquoise (1). | - | Unknown |
7 | ZBTB16 | 3 | 3 | Blue(1), Brown (1), Turquoise (1). | Hungtinton’s Disease [34] | Known |
8 | EZF1 | 3 | 3 | Blue (1), Brown (1), Turquoise (1) | Parkinson’s Disease [35] | known |
9 | TRMT1 | 3 | 3 | Blue (1), Brown (1), Turquoise (1). | Oxidative damage in Neurodegenrative diseases [36] | Known |
10 | SSRP1 | 3 | 3 | Blue (1), Brown (1), Turquoise (1). | Alzheimer’s Disease [37] | Known |