From: Comparison of weighting approaches for genetic risk scores in gene-environment interaction studies
Weights for GRS | GRSxE interaction | |||||
---|---|---|---|---|---|---|
N | GSTP1 rs1138272 | GSTP1 rs1695 | TNF rs1800629 | OR^{a} | p-value | |
GRS with weights from pooled marginal genetic effects^{b} | 593 | ln(1.49) ≈ 0.40 | ln(0.91) ≈ −0.09 | ln(1.04) ≈ 0.04 | 16.31 | 0.004 |
GRS-marginal-internal^{c} | 593 | 0.69 | −0.09 | 0.00 | 8.83 | 0.004 |
GRS-interaction-training (1:1)^{d,e} | 296 | 0.63 | 0.00 | 0.00 | 9.71 | 0.028 |
GRS-interaction-training (1:2)^{d,f} | 395 | 0.64 | 0.00 | 0.00 | 9.24 | 0.014 |
GRS-interaction-training (1:3)^{d,g} | 444 | 0.85 | 0.00 | 0.00 | 7.34 | 0.007 |