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Fig. 2 | BMC Genetics

Fig. 2

From: High resolution melting curve analysis targeting the HBB gene mutational hot-spot offers a reliable screening approach for all common as well as most of the rare beta-globin gene mutations in Bangladesh

Fig. 2

HRM-based screening of HBB gene mutations. a Normalized and temperature shifted difference curve patterns of c.79G > A and c.92 + 5G > C, (b) Normalized and temperature shifted difference curve patterns of c.126_129delCTTT, (c) Normalized and temperature shifted difference curve patterns of c.27_28insG, c.46delT, c.47G > A and c.92G > C, and (d) Normalized and temperature shifted difference curve patterns of c.92 + 130G > C, c.126delC and c.135delC alleles. The curve shape generated by each mutant allele was compared to its wild type counterpart and other mutant alleles. * indicates heterozygous alleles and # indicates homozygous alleles

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