BMC Genomic Data

Table 1 Type I error rate of \( {\tilde{Z}}_C \) and \( {TDT}_{\mathrm{BRV}} \)

From: Rare variant association analysis in case-parents studies by allowing for missing parental genotypes

	\( {\tilde{Z}}_C \)						\( {TDT}_{\mathrm{BRV}} \)
	α = 0.05			α = 0.001			α = 0.05			α = 0.001
	Sample size (N)			Sample size (N)			Sample size (N)			Sample size (N)
Homogeneous population	N₀ + \( \frac{1}{10} \) N₀	N₀ + \( \frac{1}{5} \) N₀	N₀ + \( \frac{1}{2} \) N₀	N₀ + \( \frac{1}{10} \) N₀	N₀ + \( \frac{1}{5} \) N₀	N₀ + \( \frac{1}{2} \) N₀	N₀ + \( \frac{1}{10} \) N₀	N₀ + \( \frac{1}{5} \) N₀	N₀ + \( \frac{1}{2} \)N₀	N₀ + \( \frac{1}{10} \) N₀	N₀ + \( \frac{1}{5} \) N₀	N₀ + \( \frac{1}{2} \) N₀
Ω_0 + Ι	0.057	0.045	0.052	0.0012	0.0014	0.0009	0.053	0.046	0.051	0.0011	0.0012	0.0010
Ω_0 + ΙΙ	0.055	0.055	0.050	0.0011	0.0008	0.0014	0.054	0.055	0.052	0.0012	0.0009	0.0014
Ω_{0 + Ι + ΙΙ}	0.048	0.049	0.046	0.0009	0.0013	0.0012	0.048	0.049	0.049	0.0009	0.0013	0.0013
Population stratification
Ω_0 + Ι	0.055	0.051	0.050	0.0013	0.0012	0.0010	0.055	0.047	0.054	0.0013	0.0012	0.0012
Ω_0 + ΙΙ	0.053	0.056	0.053	0.0014	0.0009	0.0014	0.056	0.054	0.051	0.0012	0.0009	0.0011
Ω_{0 + Ι + ΙΙ}	0.049	0.049	0.051	0.0009	0.0013	0.0014	0.048	0.050	0.047	0.0009	0.0010	0.0014

Note: The sample size N = N₀ + N_I, N = N₀ + N_II, N = N₀ + N_I + N_II for Ω_0 + Ι, Ω_0 + ΙΙ, and Ω_0+Ι+ΙΙ, respectively, with N₀ (=500) complete case-parents trios (Ω₀). There are N_I case-parents trios of Ω_I forΩ_0 + Ιand N_II case-parents trios of Ω_II for Ω_0 + ΙΙ with N_I, N_II=\( \frac{1}{10} \)N₀, \( \frac{1}{5} \)N₀, and \( \frac{1}{2} \)N₀, respectively. For Ω_0+Ι+ΙΙ, N_I = N_II, and N_I + N_II = \( \frac{1}{10} \)N₀, \( \frac{1}{5} \)N₀, and \( \frac{1}{2} \)N₀, respectively

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