Fig. 1From: Genetic loci for resistance to podocyte injury caused by the tensin2 gene deficiency in miceGlomerular histology and urinary albumin excretion in Tns2-deficient B6, FVB and F1 mice. (a) Schema of the study. b Representative glomerular structures in PAS staining. In B6-Tns2nph mice, most glomeruli were normal (left panel), while some glomeruli showed a slight increase in mesangial matrix (right panel). In FVB-Tns2nph mice, many glomeruli showed marked expansion of the mesangial matrix, marked thickening of the GBM and abnormal dilation of the capillary lumen. In F1 mice, there were normal glomeruli (left panel), glomeruli with mesangial expansion (middle panel) and glomeruli with GBM thickening (right panel). c Urinary albumin excretion in FVB-Tns2nph (n = 15), B6-Tns2nph (n = 5) and F1 (n = 8) mice. Values represent the mean. Asterisk, P < 0.01Back to article page