TelNet - a database for human and yeast genes involved in telomere maintenance

BMC Genomic Data

Table 1 Screening studies and database information included in TelNet for identification of TM genes

Method	Organism / cell line	# genes/proteins	Ref.
Proteomics of isolated chromatin segments (PICh)	human / Wi38-VA13 HeLa 1.2.11	296	[14]
Quantitative telomeric chromatin isolation protocol (QTIP)	human / HeLa	34	[38]
Protein network analysis surrounding telomere repeat binding factors, TRF1, TRF2, and POT1 using dual-tag affinity purification in combination with multidimensional protein identification technology liquid chromatography - tandem mass spectrometry (MudPIT LC-MS/MS)	human / 293 T	211	[16]
Protein complementation assay (PCA/bimolecular fluorescent complementation (BiFC)) of shelterin compounds and ~ 12.000 candidate genes; GST-pulldown of FLAG-tagged genes	human / HTC75	339	[17]
siRNA mediated knockdown; APB formation	human / U2OS	29	[23, 39]
Proteomic analysis of deregulated genes upon telomere shortening caused by the telomerase inhibitor GRN163	human / SK-N-MC	99	[24]
QTRAP: kinase library screen	human / HeLa	109	[18]
Telomerase regulators affecting its transcription	human / various	53	[19]
Gene set with potential relevance to telomeres and the ALT pathway	human / various	297	[41]
Telomerase activity signature	human	43	[40]
GO annotation containing the term “telo”	human	245	[44]
Haploid deletion screen, telomere length	yeast	166	[26]
Telomere length-variation screen in deletion strains	yeast	138	[27]
Screen of DAmP collection	yeast	77	[28]
Telomerase null screen of yeast mutants	yeast	270	[42]
Telomerase regulators from the Yeastract database	yeast	35	[43]
GO annotation containing the term “telo”	yeast	192	[44]

ISSN: 2730-6844