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Table 6 Summary of enriched Gene Ontology (GO) molecular function (MF) terms among total identified Pfam protein family domains

From: Genome sequencing and protein domain annotations of Korean Hanwoo cattle identify Hanwoo-specific immunity-related and other novel genes

term_ID description Frequencya log10 p-value Uniquenessb
GO:0003700 sequence-specific DNA binding transcription factor activity 5.30% −10.6576 0.958
GO:0003712 transcription cofactor activity 1.78% −39.8861 0.957
GO:0003824 catalytic activity 37.22% −13.4559 0.972
GO:0004871 signal transducer activity 11.94% −25.4318 0.927
GO:0004930 G-protein coupled receptor activity 7.87% −27.6198 0.925
GO:0005089 Rho guanyl-nucleotide exchange factor activity 0.48% −11.699 0.956
GO:0005216 ion channel activity 2.49% −13.9208 0.896
GO:0015075 ion transmembrane transporter activity 5.28% −5.7959 0.895
GO:0016773 phosphotransferase activity, alcohol group as acceptor 4.60% −58.7447 0.771
GO:0004672 protein kinase activity 3.87% − 14.1308 0.772
GO:0043015 gamma-tubulin binding 0.10% −25.8539 0.878
GO:0008017 microtubule binding 1.06% −16.4815 0.848
GO:0019001 guanyl nucleotide binding 2.48% −25.4318 0.846
GO:0005509 calcium ion binding 3.94% −19.0655 0.863
GO:0005515 protein binding 26.71% −7.3665 0.92
GO:0004488 methylenetetrahydrofolate dehydrogenase (NADP+) activity 0.02% −13.4559 0.878
GO:0003755 peptidyl-prolyl cis-trans isomerase activity 0.26% −19.9208 0.876
GO:0003777 microtubule motor activity 0.51% −45.6021 0.814
GO:0005544 calcium-dependent phospholipid binding 0.17% −19.0655 0.844
GO:0042802 identical protein binding 4.77% −25.8539 0.878
GO:0031683 G-protein beta/gamma-subunit complex binding 0.16% −25.4318 0.883
GO:0043565 sequence-specific DNA binding 4.31% −10.6576 0.855
GO:0016787 hydrolase activity 15.05% −7.8861 0.841
GO:0008484 sulfuric ester hydrolase activity 0.11% −31.7447 0.832
GO:0004181 metallocarboxypeptidase activity 0.15% −32.6778 0.809
GO:0004222 metalloendopeptidase activity 0.79% −15 0.79
GO:0019901 protein kinase binding 1.80% −7.2007 0.885
GO:0008479 queuine tRNA-ribosyltransferase activity 0.02% −34.7447 0.849
GO:0003676 nucleic acid binding 21.33% −8.6021 0.849
GO:0005102 receptor binding 6.56% −62.1871 0.875
GO:0004402 histone acetyltransferase activity 0.24% −51.3372 0.812
GO:0003677 DNA binding 10.28% −9.5376 0.843
GO:0008408 3′-5′ exonuclease activity 0.18% −31.0655 0.827
GO:0016746 transferase activity, transferring acyl groups 1.42% −30.9208 0.805
GO:0003723 RNA binding 7.68% −5.9208 0.847
GO:0046872 metal ion binding 20.96% −4.5376 0.845
GO:0004550 nucleoside diphosphate kinase activity 0.14% −55.585 0.816
GO:0008236 serine-type peptidase activity 1.32% −7.1739 0.793
GO:0008270 zinc ion binding 6.73% −4.2076 0.856
GO:0004129 cytochrome-c oxidase activity 0.43% −12.5686 0.809
GO:0003924 GTPase activity 1.03% −25.4318 0.806
GO:0005524 ATP binding 8.83% −14.1308 0.751
GO:0000166 nucleotide binding 14.40% −7.3565 0.823
GO:0003810 protein-glutamine gamma-glutamyltransferase activity 0.07% −14.7696 0.823
GO:0005543 phospholipid binding 1.33% −16.6021 0.829
GO:0035091 phosphatidylinositol binding 0.84% −17 0.829
  1. aFrequency represents the proportion of the specified GO term within the entire Bos Taurus species-specific Uniprot protein annotation database. Higher frequencies represent more general and common terms, while terms with a lower frequency are rare and specific
  2. bUniqueness represents whether a term is an outlier when compared semantically to the list as a whole