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Table 1 The top 10 enriched Gene Ontology terms for down-regulated and up-regulated DEGs

From: Molecular mechanism of estrogen-mediated neuroprotection in the relief of brain ischemic injury

  Category Term Count PValue Genes
  CC GO:0044459~plasma membrane part 39 4.14E-07 OPRM1, CYB5R3, TLN1, RAB3C, RAB3D…
  BP GO:0006916~anti-apoptosis 4 1.69E-06 SERPINB9, SQSTM1, ADAM17, CITED2
  CC GO:0005886~plasma membrane 54 1.88E-06 P2RX1, MC4R, CACNA1D, SCN4A, CACNA1A…
Down-regulated DEGs BP GO:0010033~response to organic substance 27 2.00E-05 P2RX1, SLC18A2, MC4R, ADAM17, FABP4…
  CC GO:0005924~cell-substrate adherens junction 8 3.96E-05 NOX4, OPRM1, TLN1, PGM5, CD44…
  CC GO:0030055~cell-substrate junction 8 5.96E-05 NOX4, OPRM1, TLN1, PGM5, CD44…
  BP GO:0007267~cell-cell signaling 14 1.17E-04 CGA, EDN3, FGFR4, RAB3C, TH…
  CC GO:0009898~internal side of plasma membrane 10 1.55E-04 TH, KIT, VPS33B, NUPL1, ADD3…
  BP GO:0003001~generation of a signal involved in cell-cell signaling 8 2.39E-04 CCKAR, CGA, EDN3, RAB3C, P2RX1…
  CC GO:0005925~focal adhesion 7 2.51E-04 NOX4, OPRM1, TLN1, PGM5, CD44…
  BP GO:0042493~response to drug 19 1.57E-08 BDNF, UGT1A9, UGT1A8, UGT1A7C, UGT1A3…
  BP GO:0044093~positive regulation of molecular function 20 2.42E-06 DPDX1, IL10, CCND1, PSMA6, IFNB1,…
  BP GO:0009725~response to hormone stimulus 20 2.63E-06 UGT1A6, UGT1A9, UGT1A8, UGT1A7C, UGT1A3…
UP-regulated DEGs BP GO:0009719~response to endogenous stimulus 20 1.40E-05 DLC1, ADCY8, NOS3, KCNMA1, LEP…
  BP GO:0006631~fatty acid metabolic process 11 3.93E-05 SCD1, LEP, ACSM3, CD36, SCD…
  CC GO:0005792~microsome 13 5.10E-05 SCD1, CYP2C6, P4HB, SCD, UGT2B1…
  CC GO:0045177~apical part of cell 11 5.61E-05 OXTR, NOS3, KLK1, RGD1565355, CLCN5…
  CC GO:0005829~cytosol 29 6.28E-05 TPN7, DNM3, LOC686737, RALBP1, VHL…
  CC GO:0042598~vesicular fraction 13 6.82E-05 ITPR1, UGT1A6, UGT1A9, UGT1A8, CD36…
  BP GO:0006916~anti-apoptosis 3 1.43E-04 BDNF, ETS1, HIPK3
  1. DEGs differentially expressed genes, BP biological process, CC cellular component