Table 1 The top 10 enriched Gene Ontology terms for down-regulated and up-regulated DEGs
From: Molecular mechanism of estrogen-mediated neuroprotection in the relief of brain ischemic injury
| Â | Category | Term | Count | PValue | Genes |
|---|---|---|---|---|---|
|  | CC | GO:0044459~plasma membrane part | 39 | 4.14E-07 | OPRM1, CYB5R3, TLN1, RAB3C, RAB3D… |
| Â | BP | GO:0006916~anti-apoptosis | 4 | 1.69E-06 | SERPINB9, SQSTM1, ADAM17, CITED2 |
|  | CC | GO:0005886~plasma membrane | 54 | 1.88E-06 | P2RX1, MC4R, CACNA1D, SCN4A, CACNA1A… |
Down-regulated DEGs | BP | GO:0010033~response to organic substance | 27 | 2.00E-05 | P2RX1, SLC18A2, MC4R, ADAM17, FABP4… |
|  | CC | GO:0005924~cell-substrate adherens junction | 8 | 3.96E-05 | NOX4, OPRM1, TLN1, PGM5, CD44… |
|  | CC | GO:0030055~cell-substrate junction | 8 | 5.96E-05 | NOX4, OPRM1, TLN1, PGM5, CD44… |
|  | BP | GO:0007267~cell-cell signaling | 14 | 1.17E-04 | CGA, EDN3, FGFR4, RAB3C, TH… |
|  | CC | GO:0009898~internal side of plasma membrane | 10 | 1.55E-04 | TH, KIT, VPS33B, NUPL1, ADD3… |
|  | BP | GO:0003001~generation of a signal involved in cell-cell signaling | 8 | 2.39E-04 | CCKAR, CGA, EDN3, RAB3C, P2RX1… |
|  | CC | GO:0005925~focal adhesion | 7 | 2.51E-04 | NOX4, OPRM1, TLN1, PGM5, CD44… |
|  | BP | GO:0042493~response to drug | 19 | 1.57E-08 | BDNF, UGT1A9, UGT1A8, UGT1A7C, UGT1A3… |
|  | BP | GO:0044093~positive regulation of molecular function | 20 | 2.42E-06 | DPDX1, IL10, CCND1, PSMA6, IFNB1,… |
|  | BP | GO:0009725~response to hormone stimulus | 20 | 2.63E-06 | UGT1A6, UGT1A9, UGT1A8, UGT1A7C, UGT1A3… |
UP-regulated DEGs | BP | GO:0009719~response to endogenous stimulus | 20 | 1.40E-05 | DLC1, ADCY8, NOS3, KCNMA1, LEP… |
|  | BP | GO:0006631~fatty acid metabolic process | 11 | 3.93E-05 | SCD1, LEP, ACSM3, CD36, SCD… |
|  | CC | GO:0005792~microsome | 13 | 5.10E-05 | SCD1, CYP2C6, P4HB, SCD, UGT2B1… |
|  | CC | GO:0045177~apical part of cell | 11 | 5.61E-05 | OXTR, NOS3, KLK1, RGD1565355, CLCN5… |
|  | CC | GO:0005829~cytosol | 29 | 6.28E-05 | TPN7, DNM3, LOC686737, RALBP1, VHL… |
|  | CC | GO:0042598~vesicular fraction | 13 | 6.82E-05 | ITPR1, UGT1A6, UGT1A9, UGT1A8, CD36… |
| Â | BP | GO:0006916~anti-apoptosis | 3 | 1.43E-04 | BDNF, ETS1, HIPK3 |