Table 1 Summary statistics and variable importance rankings of simulated causal effects on TG
RF* | RF-RFE | ||||||
|---|---|---|---|---|---|---|---|
r2 | −0.00203 | 0.19217a | |||||
MSEOOB | 0.07378 | 0.05948a | |||||
Chr | Causal SNP/CpG | MAF or Mean (SD) | Simulated h2† | Main Effects, β(SE), p value | Interaction Effects, β(SE), p value | Rank (percentile rank) | |
1 | rs9661059 | 0.12 | 0.125 | .14 (0.02), <0.0001 | −0.19 (0.07), 0.0109 | 1 (100.0) | 20 (100.0) |
cg00000363 | 0.49 (0.33) | – | −0.05 (0.03), 0.0873 | 8680 (97.6) | 239,755 (32.7) | ||
6 | rs736004 | 0.09 | 0.075 | 0.09 (0.03), 0.0005 | −0.30 (0.08), 0.0001 | 13,480 (96.2) | 766 (99.8) |
cg10480950 | 0.54 (0.33) | – | −0.04 (0.03), 0.1711 | 5332 (98.5) | 232,579 (34.7) | ||
8 | rs1012116 | 0.20 | 0.100 | 0.08 (0.02), <0.0001 | −0.21 (0.06), 0.0002 | 50,218 (85.9) | 333,504 (6.4) |
cg18772399 | 0.56 (0.33) | – | −0.002 (0.03), 0.9466 | 339,475 (4.7) | 301,855 (15.3) | ||
10 | rs10828412 | 0.14 | 0.025 | 0.07 (0.02), 0.0007 | −0.07 (0.07), 0.2770 | 2984 (99.2) | 330,516 (7.3) |
cg00045910 | 0.49 (0.34) | – | 0.01 (0.03), 0.7176 | 263,465 (26.1) | 231,315 (35.1) | ||
17 | rs4399565 | 0.41 | 0.050 | 0.04 (0.02), 0.0142 | −0.13 (0.05), 0.0038 | 11,078 (96.9) | 196,276 (44.9) |
cg01242676 | 0.46 (0.32) | – | 0.01 (0.03), 0.8159 | 350,420 (1.9) | 350,420 (1.7) | ||