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Table 2 Variation in estimated intra- and interclass correlation coefficients across relative paired groups and subtypes (N > 50) at 3 MetS-related CpG methylation loci unadjusted and adjusted for fixed covariates in 993 participants from 188 families with nonmissing covariates and methylation information at visit 2 in the GOLDN study

From: Characterization of the contribution of shared environmental and genetic factors to metabolic syndrome methylation heritability and familial correlations

Pair Type

Na

Familial Correlations

Expectationb

cg00574958 at CPT1A

cg17058475 at CPT1A

cg18181703 in SOCS3

cg06500161 in ABCG1

h2 = 0.316

h2 = 0.355

h2 = 0.566

h2 = 0.306

Unadj.

Adj.

Unadj.

Adj.

Unadj.

Adj.

Unadj.

Adj.

Parent–offspring

541

h2/2

0.1721

0.1578

0.0986

0.0900

0.2964

0.2887

0.2267

0.2081

Mother–daughter

158

h2/2

0.2240

0.2565

0.2094

0.2572

0.2590

0.2591

0.1755

0.1537

Mother–son

146

h2/2

0.2302

0.1868

0.0750

0.0625

0.2207

0.2525

0.1775

0.1766

Father–daughter

129

h2/2

0.0422

0.0729

0.1766

0.1774

0.4510

0.4239

0.3417

0.3415

Father–son

108

h2/2

0.1967

0.2588

0.0480

0.0172

0.2813

0.2477

0.2071

0.1982

Siblings

588

h2/2

0.2224

0.1906

0.2071

0.2043

0.3295

0.3114

0.1185

0.1039

Brother–brother

145

h2/2

0.2396

0.2333

0.2328

0.2359

0.2668

0.2413

0.0647

0.0555

Sister–brother

276

h2/2

0.2075

0.1562

0.1496

0.1556

0.3252

0.2774

0.1187

0.0978

Sister–sister

167

h2/2

0.2245

0.3141

0.2680

0.2517

0.3769

0.3577

0.1490

0.1478

Grandparents–grandchildren

75

h2/4

0.0924

0.1020

0.0781

0.0807

0.3342

0.2892

0.0164

0.0064

Avuncular

553

h2/4

0.0685

0.0893

0.1323

0.1272

0.1440

0.1691

0.1632

0.1410

First cousins

247

h2/8

0.0227

0.0007

− 0.0393

− 0.0584

− 0.1394

− 0.1392

0.1411

0.1362

Great-avuncular

53

h2/8

0.0005

0.0266

0.1279

0.2092

− 0.0215

− 0.0453

0.5514

0.5249

First cousins once removed

71

h2/16

0.0486

0.1987

0.3085

0.2066

− 0.2466

− 0.2190

0.2418

0.1984

Parent–parent

65

0

0.1412

0.1221

− 0.0982

− 0.1432

0.0507

0.0164

0.0613

0.0505

Unrelatedc

91

0

− 0.0089

− 0.0236

0.0126

− 0.0231

− 0.0181

− 0.0235

− 0.0011

− 0.0002

MS Concordant

91

0

0.1420

0.1130

0.1602

0.1270

− 0.0399

− 0.0580

− 0.0051

− 0.0408

MS Discordant

76

0

− 0.1354

− 0.1284

− 0.1547

− 0.1515

− 0.1718

− 0.1566

0.0291

0.1017

  1. Values in bold represent estimates that are nonzero with a P value < 0.05
  2. Abbreviations: Adj. Calculated on residuals created after adjusting for fixed covariates age, age2, sex, center, and current smoking, MS National Cholesterol Education Program Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults Metabolic Syndrome status at visit 2, Unadj. unadjusted for any covariates
  3. aPairings may not be independent
  4. bThe expected correlation under a genetic model with a heritability of h2
  5. cOverall unrelated correlation assigned by subsetting to the 182 individuals from distinct families and randomly pairing them, whereas concordant and discordant strata were calculated after randomly pairing within or across the National Cholesterol Education Program Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults criteria for MetS cases (N = 76) and controls (N = 106)
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