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Table 1 Association results between SNPs associated with TGs (TG1–2or TG3–4 or ΔTG1–4) under the POO model and nearby DNA methylation probes associated with TGs (TG2 or ΔTG2–4), with or without taking the POO effect into account

From: Investigation of parent-of-origin effects induced by fenofibrate treatment on triglycerides levels

SNP

Chr:Pos (Mb)

Gene

Pheno

Alleles a1/a2

Freq a1

TGs = SNP + covariates

TGs = Meth2 + covariates

Meth2 = SNP + covariates + TGs

P

P of

P ot

P om_op

P op_om

Probe

Pos (Mb)

P

P

P of

P ot

P om_op

P op_om

rs2903839

2:56.17

 

TG1–2

A/G

0.59

0.16

2.7 × 10−7

1.5 × 10− 7

1.8 × 10− 6

0.01

cg07468585

56.2

0.02

0.53

0.02

0.39

0.21

0.01

           

cg25249448

56.2

0.03

0.55

0.04

0.16

0.62

0.01

rs13131918

4:24.87

CCDC149

TG1–2

A/G

0.52

0.07

2.8 × 10−7

1.4 × 10−7

0.004

7.0 × 10−7

cg09490880

24.9

0.04

0.02

0.72

0.52

0.42

0.85

rs7300117

12:131.7

 

TG1–2

A/T

0.52

6.2 × 10−9

3.8 × 10−5

0.07

0.11

3.9 × 10− 5

cg09481537

131.7

0.04

0.09

0.06

0.16

0.70

0.02

rs301621

16:86.65

 

ΔTG1–4

G/T

0.60

0.18

1.5 × 10−5

0.01

0.40

1.2 × 10− 5

cg10206250

86.6

0.04

0.19

0.02

0.008

0.01

0.10

rs10417097*

19:19.72

PBX4

TG1–2

C/G

0.62

0.01

3.0 × 10−5

6.4 × 10−5

0.23

8.0 × 10−6

cg10738025

19.7

0.03

0.005

0.47

0.92

0.34

0.49

rs10417097*

19:19:72

PBX4

TG3–4

C/G

0.62

0.009

3.0 × 10−6

6.8 × 10−6

0.13

8.5 × 10−7

  1. *SNP located in a locus previously reported to be associated with TGs (rs17216525-T, beta = 0.11, P = 4.0 × 10− 11)
  2. Statistical significances of: (a) the test when maternal and paternal inherited alleles are modeled separately (βpat = βmat = 0, P of), (b) the test for difference between paternal and maternal transmissions (βpat = βmat, P ot), (c) the test of maternal effect only (βmat = 0, P om_op), and (d) the test of paternal effect only (βpat = 0, P op_om)