Table 2 Differentially methylated regions (DMRs) associated with SHBG, total testosterone and bioavailable testosterone
From: Associations of sex hormone-binding globulin and testosterone with genome-wide DNA methylation
| Â | Differentially methylated region (DMR) | N CpGs | Åœidak p-value | Gene | Rangea |
|---|---|---|---|---|---|
SHBG | |||||
 Adolescence | |||||
  Females | Chr8:57350735–57351068 | 5 | 1.1E-04 | – | 0.014, 0.035 |
  Females | Chr16:53407594–53407809 | 3 | 3.8E-03 | – | 0.011, 0.031 |
 Childhood | |||||
  Males | Chr4:124232–124623 | 3 | 9.9E-04 | ZNF718 | 0.0053, 0.018 |
Total testosterone | |||||
 Childhood | |||||
  Males | Chr3:126911727–126911954 | 4 | 8.4E-06 | – | − 0.038, − 0.015 |
  Males | Chr10:10337051–10337313 | 2 | 1.4E-04 | – | −0.034, − 0.02 |
  Males | Chr6:53530503–53530629 | 4 | 2.6E-04 | KLHL31 | −0.022, − 0.0091 |
 Adolescence | |||||
  Males | Chr6:53530503–53530629 | 4 | 1.1E-05 | KLHL31 | −0.022, − 0.012 |
  Males | Chr4:57547347–57547700 | 2 | 9.5E-04 | HOPX | −0.035, − 0.027 |
  Males | Chr15:93580022–93580328 | 4 | 1.3E-03 | – | −0.055, − 0.013 |
Bioavailable testosterone | |||||
 Childhood | |||||
  Males | Chr4:124232–124694 | 4 | 9.3E-09 | ZNF718 | −0.019, − 0.0064 |
  Males | Chr5:78985432–78985593 | 7 | 2.4E-04 | CMYA5 | −0.031, − 0.024 |
  Males | Chr15:26874098–26874364 | 3 | 8.0E-03 | GABRB3 | −0.037, − 0.024 |
 Adolescence | |||||
  Males | Chr5:78985432–78985901 | 8 | 6.5E-05 | CMYA5 | −0.044, − 0.022 |