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Table 2 Differentially methylated regions (DMRs) associated with SHBG, total testosterone and bioavailable testosterone

From: Associations of sex hormone-binding globulin and testosterone with genome-wide DNA methylation

  Differentially methylated region (DMR) N CpGs Ŝidak p-value Gene Rangea
SHBG
 Adolescence
  Females Chr8:57350735–57351068 5 1.1E-04 0.014, 0.035
  Females Chr16:53407594–53407809 3 3.8E-03 0.011, 0.031
 Childhood
  Males Chr4:124232–124623 3 9.9E-04 ZNF718 0.0053, 0.018
Total testosterone
 Childhood
  Males Chr3:126911727–126911954 4 8.4E-06 − 0.038, − 0.015
  Males Chr10:10337051–10337313 2 1.4E-04 −0.034, − 0.02
  Males Chr6:53530503–53530629 4 2.6E-04 KLHL31 −0.022, − 0.0091
 Adolescence
  Males Chr6:53530503–53530629 4 1.1E-05 KLHL31 −0.022, − 0.012
  Males Chr4:57547347–57547700 2 9.5E-04 HOPX −0.035, − 0.027
  Males Chr15:93580022–93580328 4 1.3E-03 −0.055, − 0.013
Bioavailable testosterone
 Childhood
  Males Chr4:124232–124694 4 9.3E-09 ZNF718 −0.019, − 0.0064
  Males Chr5:78985432–78985593 7 2.4E-04 CMYA5 −0.031, − 0.024
  Males Chr15:26874098–26874364 3 8.0E-03 GABRB3 −0.037, − 0.024
 Adolescence
  Males Chr5:78985432–78985901 8 6.5E-05 CMYA5 −0.044, − 0.022
  1. aRange of effect sizes observed across CpGs comprising that DMR reported to 2 significant figures, where estimates are change in methylation beta per SD increase in SHBG or testosterone