Fig. 3

Summary of single nucleotide polymorphisms (SNPs). b The table shows the number of SNPs in each exon that were found in our hGR screenings compared to the survey of the dbSNP and publications. Our screenings identified 1481 SNPs in exons 2 through 9: 1465 in the coding regions and an additional 16 in the 3’UTR. The corresponding domains are shown on the top: Transactivation (Tran.), DNA-binding domain (DBD), hinge region (H), and ligand-binding domain (LBD), as well as the 5′ and 3′ untranslated regions (UTR). Intronic SNPs are not shown. b A representation of SNPs (found in six or more clones) from our screening is displayed with the nucleotide change indicated above the isoform. Domains are indicated with shading. Green, italic = synonymous substitution; Red = premature termination