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Table 1 Type I error comparison of three methods for different types of phenotypes

From: An integrative U method for joint analysis of multi-level omic data

phenotype distributions

Bernoulli

Gaussian

T 2

T 4

DE

IU

0.048

0.049

0.052

0.055

0.052

VCT

0.046

0.053

0.091

0.068

0.075

Adj-SKAT

0.035

0.055

0.129

0.062

0.064

  1. Bernoulli, Gaussian, T, and DE correspond to Binary, Gaussian-distributed, T-distributed, and Double-exponential distributed phenotypes. The nominal size of the test is 0.05 and n=200