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Table 2 P values from paired Mann-Whitney U Test between Biobank and Wellderly for different subsets of nonsynonymous SNPs

From: Genome-wide analysis indicates association between heterozygote advantage and healthy aging in humans

  All genes OMIM recessive genes OMIM dominant genes
SNP# MAF HETO Fa SNP# MAF HETO Fa SNP# MAF HETO Fa
0.01 ≤ MAF < 0.05 3731 0.107 0.201 0.750 219 0.053 0.056 0.648 87 9.7e-4 c 0.002 c 0.07
0.05 ≤ MAF < 0.1 1243 0.638 0.459 0.095 81 0.089 0.688 0.189 30 0.155 0.430 0.626
0.1 ≤ MAF < 0.25 1548 0.049 0.003 b 0.101 66 0.645 0.710 0.954 35 0.276 0.30 0.518
0.25 ≤ MAF < 0.5 1175 0.126 0.133 0.359 61 0.401 0.007 b 0.015b 20 0.896 0.856 0.588
Total 7697 0.30 0.165 0.608 427 0.612 0.042b 0.112 172 0.053 0.035c 0.133
  1. P values in bold pass multiple testing correction (FDR adjusted P < 0.1)
  2. aF: excess of heterozygosity
  3. bDirection: Biobank < Wellderly
  4. cDirection: Biobank > Wellderly