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Table 2 Effects of Glo1-regulating reagents on the apoptosis pathway mediated by TNF-α

From: Glyoxalase 1 gene improves the antistress capacity and reduces the immune inflammatory response

 

LPO (nmol/mg)

TNFα (g/L)

Caspase 9 (IU/L)

Caspase 3 (IU/L)

Cytochrome c (nmol/L)

Control 0

0.23 ± 0.08a

2.47 ± 0.15a

36.90 ± 2.45a

42.66 ± 3.23a

123.23 ± 4.05a

Control 8

0.97 ± 0.06b

12.00 ± 0.23b

90.89 ± 4.22b

89.28 ± 3.45b

435.34 ± 6.38b

Glo 1 agonists

0.54 ± 0.07c

3.32 ± 0.45c

52.38 ± 3.13c

48.58 ± 6.43a

204.55 ± 12.45c

NaCl

0.46 ± 0.04c

2.49 ± 0.23a

42.89 ± 3.13d

49.46 ± 2.69c

180.43 ± 5.34d

CaCl2

1.24 ± 0.05d

11.56 ± 0.33b

89.34 ± 6.19b

98.33 ± 6.67d

590.83 ± 14.65e

Mg Cl2

0.98 ± 0.04b

12.03 ± 0.45b

106.23 ± 10.48e

89.45 ± 3.13b

467.93 ± 7.12f

KCl

0.73 ± 0.07e

5.32 ± 0.43d

80.78 ± 8.34b

56.78 ± 4.78e

304.43 ± 9.43g

Sorbitol

0.50 ± 0.06c

2.35 ± 0.33a

38.49 ± 3.13a

45.48 ± 7.29a

178.93 ± 10.82d

  1. Values presented are the means of three replicates. Means in the same column with different superscript letters are significantly different (P < 0.05)