From: Genome-wide association study of morbid obesity in Han Chinese
CHR | SNP | POSITION | Gene (Nearest) | Minor Allele | 1st Stage | 2nd Stage | Joint analysis (1st + 2nd) | |||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
OR | SE | Raw-p | OR | SE | Raw-p | OR | SE | Raw-p | Bonferroni (Raw-p ×  52) | |||||
16 | rs8050136 | 53,816,275 | FTO | A | 1.73 | 0.11 | 2.11E-07 | 1.37 | 0.09 | 9.37E-04 | 1.51 | 0.07 | 7.80E-10$ | 4.13E-08* |
16 | rs9939609 | 53,820,527 | FTO | A | 1.73 | 0.11 | 2.20E-07 | 1.35 | 0.10 | 1.58E-03 | 1.51 | 0.07 | 1.32E-09$ | 7.00E-08* |
16 | rs1421085 | 53,800,954 | FTO | C | 1.65 | 0.10 | 1.31E-06 | 1.32 | 0.09 | 3.18E-03 | 1.46 | 0.07 | 1.54E-08$ | 8.16E-07* |
16 | rs9941349 | 53,825,488 | FTO | T | 1.62 | 0.09 | 2.82E-07 | 1.42 | 0.18 | 4.83E-02 | 1.48 | 0.07 | 9.05E-08 | 4.80E-06* |
16 | rs1121980 | 53,809,247 | FTO | A | 1.59 | 0.09 | 1.16E-06 | 1.19 | 0.09 | 5.35E-02 | 1.36 | 0.06 | 7.27E-07 | 3.85E-05* |
16 | rs9937354 | 53,799,847 | FTO | A | 1.57 | 0.09 | 1.18E-06 | 1.38 | 0.18 | 7.46E-02 | 1.43 | 0.07 | 6.65E-07 | 3.52E-05* |
16 | rs12925846 | 6,926,667 | RBFOX1 | G | 0.68 | 0.09 | 6.04E-06 | 0.87 | 0.08 | 6.68E-02 | 0.78 | 0.06 | 6.21E-06 | 3.29E-04* |
16 | rs17235335 | 6,928,991 | RBFOX1 | G | 0.69 | 0.09 | 1.30E-05 | 0.88 | 0.08 | 8.06E-02 | 0.79 | 0.05 | 1.26E-05 | 6.68E-04* |
14 | rs11626956 | 51,850,031 | N/A | G | 1.40 | 0.08 | 9.57E-06 | 1.09 | 0.07 | 2.39E-01 | 1.23 | 0.05 | 3.35E-05 | 0.0018* |
18 | rs2126015 | 65,545,054 | RP11-638 L3.1 | C | 0.70 | 0.08 | 1.76E-05 | 0.90 | 0.07 | 1.69E-01 | 0.81 | 0.05 | 4.64E-05 | 0.0025* |
12 | rs159702 | 29,748,233 | TMTC1 | C | 1.44 | 0.09 | 7.31E-05 | 1.15 | 0.08 | 8.60E-02 | 1.25 | 0.06 | 1.50E-04 | 0.0080* |
20 | rs6069477 | 54,491,980 | CBLN4 | A | 1.40 | 0.08 | 9.40E-06 | 1.05 | 0.07 | 5.02E-01 | 1.20 | 0.05 | 2.87E-04 | 0.015* |
8 | rs16883931 | 113,664,153 | CSMD3 | G | 1.36 | 0.08 | 7.40E-05 | 1.12 | 0.07 | 1.22E-01 | 1.20 | 0.05 | 3.99E-04 | 0.021* |
2 | rs6757087 | 212,680,523 | ERBB4 | G | 1.46 | 0.08 | 5.19E-07 | 1.00 | 0.07 | 9.68E-01 | 1.19 | 0.05 | 5.49E-04 | 0.029* |
2 | rs9808434 | 18,694,885 | N/A | C | 1.45 | 0.09 | 1.29E-05 | 1.05 | 0.08 | 5.59E-01 | 1.20 | 0.06 | 8.83E-04 | 0.047* |
8 | rs72621457 | 64,548,431 | LOC102724612 | G | 0.70 | 0.09 | 5.12E-05 | 0.96 | 0.08 | 5.64E-01 | 0.83 | 0.06 | 1.12E-03 | 0.059 |
4 | rs12649045 | 122,957,607 | TRPC3, KIAA1109 | T | 0.71 | 0.08 | 1.40E-05 | 1.03 | 0.07 | 7.12E-01 | 0.85 | 0.05 | 1.31E-03 | 0.069 |
8 | rs3104994 | 96,571,283 | LOC100616530, C8orf37-AS1 | C | 1.54 | 0.11 | 4.84E-05 | 1.03 | 0.10 | 7.43E-01 | 1.24 | 0.07 | 1.84E-03 | 0.098 |
5 | rs258019 | 115,807,688 | CTB-118 N6.3 / SEMA6A | C | 0.74 | 0.08 | 8.26E-05 | 0.98 | 0.07 | 7.29E-01 | 0.86 | 0.05 | 2.39E-03 | 0.13 |
1 | rs3003482 | 17,550,601 | PADI1 | G | 0.70 | 0.08 | 1.02E-05 | 1.00 | 0.07 | 9.65E-01 | 0.86 | 0.05 | 3.01E-03 | 0.16 |
18 | rs76010193 | 65,526,327 | RP11-638 L3.1 | T | 0.73 | 0.08 | 5.21E-05 | 0.98 | 0.07 | 7.54E-01 | 0.86 | 0.05 | 2.89E-03 | 0.15 |
9 | rs74596508 | 89,361,079 | LOC102724080, GAS1 | G | 0.60 | 0.14 | 2.71E-04 | 0.95 | 0.26 | 8.38E-01 | 0.71 | 0.12 | 3.19E-03 | 0.17 |
3 | rs4859033 | 88,518,323 | N/A | G | 0.73 | 0.08 | 2.03E-04 | 0.93 | 0.08 | 3.67E-01 | 0.85 | 0.06 | 3.85E-03 | 0.20 |
5 | rs34971 | 115,795,188 | CTB-118 N6.3 / SEMA6A | T | 1.36 | 0.08 | 4.25E-05 | 0.99 | 0.07 | 8.63E-01 | 1.15 | 0.05 | 4.34E-03 | 0.23 |
12 | rs7136269 | 58,075,937 | RPL13AP23 (Pseudo), OS9 | A | 0.73 | 0.08 | 9.66E-05 | 1.02 | 0.15 | 9.19E-01 | 0.84 | 0.06 | 4.71E-03 | 0.25 |
4 | rs985591 | 63,331,949 | N/A | T | 1.39 | 0.09 | 1.28E-04 | 1.02 | 0.08 | 8.37E-01 | 1.17 | 0.06 | 5.22E-03 | 0.28 |
13 | rs9571975 | 69,218,765 | RPS3AP52 (Pseudo), RPL12P34 (Pseudo) | A | 1.47 | 0.09 | 3.02E-05 | 0.94 | 0.09 | 4.81E-01 | 1.19 | 0.06 | 5.75E-03 | 0.30 |
5 | rs79393925 | 80,873,159 | SSBP2 | C | 0.46 | 0.21 | 1.47E-04 | 0.76 | 0.21 | 1.86E-01 | 0.67 | 0.15 | 5.84E-03 | 0.31 |
12 | rs10876994 | 58,064,737 | RPL13AP23 (Pseudo) | A | 0.75 | 0.08 | 1.60E-04 | 1.12 | 0.15 | 4.59E-01 | 0.85 | 0.06 | 6.15E-03 | 0.33 |
11 | rs2575826 | 14,474,971 | N/A | T | 0.63 | 0.12 | 2.00E-04 | 0.98 | 0.11 | 8.69E-01 | 0.81 | 0.08 | 6.64E-03 | 0.35 |
16 | rs205186 | 25,574,869 | N/A | T | 1.52 | 0.12 | 4.98E-04 | 1.05 | 0.11 | 6.67E-01 | 1.24 | 0.08 | 7.49E-03 | 0.40 |
3 | rs59778278 | 120,809,596 | STXBP5L | A | 0.53 | 0.15 | 2.31E-05 | 0.89 | 0.14 | 4.00E-01 | 0.77 | 0.10 | 1.04E-02 | 0.55 |
16 | rs237140 | 26,645,648 | N/A | C | 0.54 | 0.15 | 5.79E-05 | 1.07 | 0.12 | 5.95E-01 | 0.80 | 0.09 | 1.51E-02 | 0.80 |
18 | rs17681801 | 50,173,621 | DCC | C | 1.35 | 0.08 | 1.92E-04 | 1.02 | 0.08 | 8.18E-01 | 1.13 | 0.05 | 1.90E-02 | 1.01 |
3 | rs117383450 | 168,549,587 | N/A | A | 0.47 | 0.21 | 3.98E-04 | 0.96 | 0.17 | 8.09E-01 | 0.74 | 0.13 | 2.11E-02 | 1.12 |
8 | rs3104999 | 96,555,479 | LOC100616530, C8orf37-AS1 | A | 1.33 | 0.08 | 2.73E-04 | 1.00 | 0.07 | 9.49E-01 | 1.12 | 0.05 | 2.35E-02 | 1.25 |
15 | rs16959465 | 33,129,842 | FMN1 | G | 0.75 | 0.08 | 3.58E-04 | 1.03 | 0.07 | 6.64E-01 | 0.89 | 0.05 | 2.37E-02 | 1.26 |
1 | rs351608 | 4,384,773 | N/A | G | 0.72 | 0.10 | 4.45E-04 | 0.94 | 0.19 | 7.42E-01 | 0.84 | 0.08 | 2.32E-02 | 1.23 |
4 | rs2350064 | 66,709,201 | N/A | T | 1.50 | 0.11 | 1.71E-04 | 1.00 | 0.10 | 9.76E-01 | 1.17 | 0.07 | 2.48E-02 | 1.31 |
17 | rs465563 | 3,513,719 | SHPK / TRPV1 | G | 1.46 | 0.08 | 3.04E-06 | 0.91 | 0.07 | 2.06E-01 | 1.12 | 0.05 | 2.92E-02 | 1.55 |
8 | rs10106743 | 52,371,648 | PXDNL | T | 0.58 | 0.16 | 4.85E-04 | 0.99 | 0.30 | 9.77E-01 | 0.76 | 0.13 | 3.10E-02 | 1.64 |
12 | rs4763799 | 12,462,567 | LRP6, MANSC1 | C | 0.71 | 0.09 | 1.64E-04 | 1.05 | 0.08 | 5.34E-01 | 0.88 | 0.06 | 3.23E-02 | 1.71 |
13 | rs9571961 | 69,167,161 | LOC102724158 | T | 1.48 | 0.09 | 2.05E-05 | 0.88 | 0.09 | 1.78E-01 | 1.14 | 0.06 | 3.57E-02 | 1.89 |
9 | rs2082632 | 8,794,253 | PTPRD | G | 0.75 | 0.08 | 4.63E-04 | 1.05 | 0.07 | 5.09E-01 | 0.90 | 0.05 | 4.30E-02 | 2.28 |
8 | rs72664169 | 90,126,780 | N/A | A | 1.34 | 0.08 | 1.25E-04 | 0.94 | 0.07 | 3.84E-01 | 1.10 | 0.05 | 5.21E-02 | 2.76 |
12 | rs61919537 | 63,058,514 | PPM1H | C | 0.62 | 0.13 | 1.35E-04 | 1.10 | 0.10 | 3.72E-01 | 0.86 | 0.08 | 5.90E-02 | 3.13 |
1 | rs351607 | 4,384,296 | RP5-1166F10.1 (Pseudo) | G | 0.70 | 0.10 | 2.30E-04 | 1.03 | 0.09 | 7.23E-01 | 0.89 | 0.06 | 6.56E-02 | 3.48 |
5 | rs17741008 | 150,896,898 | FAT2 / SLC36A1 | T | 0.71 | 0.10 | 4.30E-04 | 1.08 | 0.08 | 3.89E-01 | 0.90 | 0.06 | 7.45E-02 | 3.95 |
2 | rs2892923 | 165,438,473 | GRB14 | C | 1.67 | 0.12 | 3.38E-05 | 0.77 | 0.13 | 5.04E-02 | 1.13 | 0.08 | 1.57E-01 | 8.32 |
1 | rs4259589 | 69,972,693 | N/A | G | 0.75 | 0.08 | 4.45E-04 | 1.16 | 0.07 | 3.88E-02 | 0.93 | 0.05 | 1.90E-01 | 10.07 |
6 | rs6907980 | 18,401,381 | RNF144B | A | 1.35 | 0.08 | 3.07E-04 | 0.88 | 0.08 | 1.15E-01 | 1.06 | 0.05 | 2.76E-01 | 14.63 |
3 | rs1449907 | 22,573,833 | N/A | G | 0.73 | 0.09 | 2.61E-04 | 1.13 | 0.07 | 9.45E-02 | 0.95 | 0.05 | 3.04E-01 | 16.11 |