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Fig. 5 | BMC Genetics

Fig. 5

From: An IL17RA frameshift variant in a Holstein cattle family with psoriasis-like skin alterations and immunodeficiency

Fig. 5

IL17RA frameshift variant associated with the observed genodermatosis. a Pedigree including the three affected calves (shown in black). All thirteen available family members were genotyped for the IL17RA variant (genotypes presented below the individuals). b IGV screenshot showing the single-nucleotide deletion on chromosome 5 in the two sequenced cases. Note the indicated change in the deduced amino acid sequence below. A premature stop codon is predicted to occur after 62 altered residues. ($ indicates the first nucleotide of codon 59 belonging to IL17RA exon 2)

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