Fig. 3

PCA plot of 3 major haplotypes (Table 2) in European (EUR), South Asian (SAS), East Asian (EAS) and African (AFR) supergroups. GWAS SNPs (Table 1) are marked in bold. eQTL casual repressive SNP rs1087483 G- > C (pos. 5) is marked in bold italics. Underlined is the high-risk allele according to GWAS reports. The low-risk allele (GWAS haplotype: AGG; on the right) is highly elevated at EAS supergroup, and is present at least at 50% in the others (Table 2)