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Table 1 Top 10 DEGs in EC tissues compared with NE tissues according to the data from TCGA database

From: Bioinformatic screening for candidate biomarkers and their prognostic values in endometrial cancer

DEG

logFC

P-value

adj. P-value

upregulated genes

 SFN

4.465258403

5.76E-42

2.15E-40

 PRAME

4.193768196

5.79E-69

7.66E-67

 MYBL2

4.109297769

2.84E-74

4.67E-72

 UBE2C

4.074765041

1.71E-69

2.33E-67

 CDC20

3.919322957

1.25E-78

2.67E-76

 AQP5

3.427650505

2.06E-18

2.18E-17

 PRSS8

3.413404932

1.96E-49

1.06E-47

 TK1

3.400033651

3.60E-77

6.98E-75

 PI3

3.370250122

7.80E-14

5.87E-13

 TPX2

3.308872927

1.19E-58

9.97E-57

downregulated genes

 DES

−6.619094047

8.36E-54

5.54E-52

 MYH11

−5.635290069

6.17E-75

1.05E-72

 CNN1

− 5.55734654

5.08E-64

5.45E-62

 ACTG2

−4.902138932

4.13E-50

2.32E-48

 LMOD1

−4.795641474

4.82E-86

1.42E-83

 OGN

−4.663558704

9.95E-120

1.55E-116

 DPT

−4.427179281

6.84E-99

3.98E-96

 SPARCL1

−4.386222474

1.33E-70

1.90E-68

 ZCCHC12

−4.328794652

2.64E-68

3.40E-66

 SFRP4

−4.266562157

4.62E-26

7.95E-25

  1. DEGs differentially expressed genes, EC endometrial cancer, NE normal endometrium, FC fold-change; adj. P-value, adjusted P-value; adjusted P-value was obtained by correcting P-value using the ‘Benjamini-Horchberg’ method