Fig. 4

Transcription factors might play a regulatory role in affecting C-to-U editing levels. a GO (gene ontology) enrichment of three sets of genes. Genes are classified into three categories according to whether they contribute positively or negatively to the editing levels. *, FDR < 0.05; **, FDR < 0.01. b Two examples of transcription factors from positive genes and negative genes respectively. The X-axis represents six samples we use, and is ranked by increasing expression level (Ribo-seq RPKM) of the gene in each plot. Y-axis is the relative editing levels in six samples, and the lowest level among six samples is shifted to zero. Each line represents an editing site that show significant correlation with that gene. c Percentages of nucleotides at the 5-prime of editing sites. Editing sites are classified based on whether they are targeted by the “positive”, “negative” or “both” genes. “bg” represents the background composition of nucleotide at the 5-prime of the 123 C-to-U editing sites in our study