Table 1 Selection of genes frequently associated with white coat colour
abbreviation | name | function | examples in ruminants | references |
|---|---|---|---|---|
AGOUTI | Agouti gene | Control of melanogenesis | Â | 2 |
AP3 | Adaptor protein 3 | Melanosome biogenesis | Â | 2 |
ASIP | Agouti-signalling peptide | Control of melanogenesis | x | 10 |
DCT | Dopachrome automerase | Melanin biosynthesis, different kinds of melanin | x | 2,4 |
EDN3 | Endothelin 3 | Melanocyte development and migration | Â | 2 |
EDNRB | Endothelin B receptor | Melanocyte development and migration | Â | 2 |
KIT | KIT gene | Melanocyte development and migration | x | 12 |
KITLG | Kit ligand | Melanocyte development and migration | x | 13 |
MART-1 | Melanoma antigen recognized by T-cells 1 | Regulation of melanin synthesis | Â | 7 |
MC1R | Melanocortin 1 receptor | Control of melanogenesis | Â | 8,14 |
MGF | mast-cell growth factor | Control of melanogenesis | x | 15 |
MITF | Microphthalmia-associated transcription factor | Control of melanogenesis | x | 16 |
MITF | microphthalmia-associated transcription factor | Transcriptomic regulation | Â | 9 |
MLPH | Melanophilin | Melanosome transport | Â | 2 |
MYO5A | Myoxin, heavy polypeptide 12 | Melanosome transport | Â | 2 |
P | Pink-eyed dilution gene | Melanosome biogenesis | Â | 6 |
PMEL17 | premelanosome protein 17 | Regulation of melanin synthesis | x | 5,17 |
POMC1 | Proopiomelanocortin 1 | Control of melanogenesis | Â | Â |
Rab27a | RAS-related gene 27 | Melanosome transport | Â | 2 |
SILV | Silver | Melanosome biogenesis | Â | 2 |
TYR | Tyrosinase | Melanin biosynthesis, different kinds of melanin | x | 1,2,3,11 |
TYRP1 | Tyrosinase-related protein 1 | Melanin biosynthesis, different kinds of melanin | x | 1,2,3 |