Complex traits and quantitative genetics

Section edited by Jim Reecy

This section incorporates all aspects of complex trait and quantitative genetics including but not limited to: mapping and association studies, the genetic basis of disease, genetics aspects of breeding and linkage analysis.

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  1. Research article

    Genome-wide association study identifies candidate genes for piglet splay leg syndrome in different populations

    Piglet splay leg syndrome (PSL) is one of the most frequent genetic defects, and can cause considerable economic loss in pig production. The present understanding of etiology and pathogenesis of PSL is poor. T...

    Xingjie Hao, Graham Plastow, Chunyan Zhang, Sutong Xu, Zhiqiu Hu, Tianfu Yang, Kai Wang, Huawei Yang, Xiaoxue Yin, Shili Liu, Zhenghua Wang, Zhiquan Wang and Shujun Zhang

    BMC Genetics 2017 18:64

    Published on: 5 July 2017

  2. Research article

    Genetic effects of PDGFRB and MARCH1 identified in GWAS revealing strong associations with semen production traits in Chinese Holstein bulls

    Using a genome-wide association study strategy, our previous study discovered 19 significant single-nucleotide polymorphisms (SNPs) related to semen production traits in Chinese Holstein bulls. Among them, thr...

    Shuli Liu, Hongwei Yin, Cong Li, Chunhua Qin, Wentao Cai, Mingyue Cao and Shengli Zhang

    BMC Genetics 2017 18:63

    Published on: 3 July 2017

  3. Research article

    Genetic correlation of the plasma lipidome with type 2 diabetes, prediabetes and insulin resistance in Mexican American families

    Differential plasma concentrations of circulating lipid species are associated with pathogenesis of type 2 diabetes (T2D). Whether the wide inter-individual variability in the plasma lipidome contributes to th...

    Hemant Kulkarni, Manju Mamtani, Gerard Wong, Jacquelyn M. Weir, Christopher K. Barlow, Thomas D. Dyer, Laura Almasy, Michael C. Mahaney, Anthony G. Comuzzie, Ravindranath Duggirala, Peter J. Meikle, John Blangero and Joanne E. Curran

    BMC Genetics 2017 18:48

    Published on: 19 May 2017

  4. Research article

    Candidate gene based association mapping in Fusarium culmorum for field quantitative pathogenicity and mycotoxin production in wheat

    Quantitative traits are common in nature, but quantitative pathogenicity has received only little attention in phytopathology. In this study, we used 100 Fusarium culmorum isolates collected from natural field en...

    Valheria Castiblanco, Jose J. Marulanda, Tobias Würschum and Thomas Miedaner

    BMC Genetics 2017 18:49

    Published on: 19 May 2017

  5. Research article

    Effects of marker density and population structure on the genomic prediction accuracy for growth trait in Pacific white shrimp Litopenaeus vannamei

    Due to the great advantages in selection accuracy and efficiency, genomic selection (GS) has been widely studied in livestock, crop and aquatic animals. Our previous study based on one full-sib family of Litopena...

    Quanchao Wang, Yang Yu, Jianbo Yuan, Xiaojun Zhang, Hao Huang, Fuhua Li and Jianhai Xiang

    BMC Genetics 2017 18:45

    Published on: 17 May 2017

  6. Research article

    A genome-wide association study reveals a locus for bilateral iridal hypopigmentation in Holstein Friesian cattle

    Eye pigmentation abnormalities in cattle are often related to albinism, Chediak-Higashi or Tietz like syndrome. However, mutations only affecting pigmentation of coat color and eye have also been described. He...

    Anne K. Hollmann, Martina Bleyer, Andrea Tipold, Jasmin N. Neßler, Wilhelm E. Wemheuer, Ekkehard Schütz and Bertram Brenig

    BMC Genetics 2017 18:30

    Published on: 29 March 2017

  7. Research article

    Genomic regions underlying susceptibility to bovine tuberculosis in Holstein-Friesian cattle

    The significant social and economic loss as a result of bovine tuberculosis (bTB) presents a continuous challenge to cattle industries in the UK and worldwide. However, host genetic variation in cattle suscept...

    Kethusegile Raphaka, Oswald Matika, Enrique Sánchez-Molano, Raphael Mrode, Mike Peter Coffey, Valentina Riggio, Elizabeth Janet Glass, John Arthur Woolliams, Stephen Christopher Bishop and Georgios Banos

    BMC Genetics 2017 18:27

    Published on: 23 March 2017

  8. Research article

    The patterns of genomic variances and covariances across genome for milk production traits between Chinese and Nordic Holstein populations

    With the development of SNP chips, SNP information provides an efficient approach to further disentangle different patterns of genomic variances and covariances across the genome for traits of interest. Due to...

    Xiujin Li, Mogens Sandø Lund, Luc Janss, Chonglong Wang, Xiangdong Ding, Qin Zhang and Guosheng Su

    BMC Genetics 2017 18:26

    Published on: 15 March 2017

  9. Research article

    Novel SNP markers in InvGE and SssI genes are associated with natural variation of sugar contents and frying color in Solanum tuberosum Group Phureja

    Potato frying color is an agronomic trait influenced by the sugar content of tubers. The candidate gene approach was employed to elucidate the molecular basis of this trait in Solanum tuberosum Group Phureja, whi...

    Diana Duarte-Delgado, Deissy Juyó, Christiane Gebhardt, Felipe Sarmiento and Teresa Mosquera-Vásquez

    BMC Genetics 2017 18:23

    Published on: 9 March 2017

  10. Review

    Opportunities and challenges of whole-genome and -exome sequencing

    Recent advances in the development of sequencing technologies provide researchers with unprecedented possibilities for genetic analyses. In this review, we will discuss the history of genetic studies and the p...

    Britt-Sabina Petersen, Broder Fredrich, Marc P. Hoeppner, David Ellinghaus and Andre Franke

    BMC Genetics 2017 18:14

    Published on: 14 February 2017

  11. Research article

    Whole-genome association analysis of pork meat pH revealed three significant regions and several potential genes in Finnish Yorkshire pigs

    One of the most commonly used quality measurements of pork is pH measured 24 h after slaughter. The most probable mode of inheritance for this trait is oligogenic with several known major genes, such as PRKAG3. I...

    Lucas L. Verardo, Marja-Liisa Sevón-Aimonen, Timo Serenius, Ville Hietakangas and Pekka Uimari

    BMC Genetics 2017 18:13

    Published on: 13 February 2017

  12. Research article

    ADAM23 is a common risk gene for canine idiopathic epilepsy

    Idiopathic or genetic adult-onset epilepsy is a common neurological disorder in domestic dogs. Genetic association has been reported only with ADAM23 on CFA 37 in few breeds. To identify novel epilepsy genes, we ...

    Lotta L. E. Koskinen, Eija H. Seppälä, Jutta Weissl, Tarja S. Jokinen, Ranno Viitmaa, Reetta L. Hänninen, Pascale Quignon, Andrea Fischer, Catherine André and Hannes Lohi

    BMC Genetics 2017 18:8

    Published on: 31 January 2017

  13. Research article

    Fat mass and obesity associated (FTO) gene influences skeletal muscle phenotypes in non-resistance trained males and elite rugby playing position

    FTO gene variants have been associated with obesity phenotypes in sedentary and obese populations, but rarely with skeletal muscle and elite athlete phenotypes.

    S. M. Heffernan, G. K. Stebbings, L. P. Kilduff, R. M. Erskine, S. H. Day, C. I. Morse, J. S. McPhee, C. J. Cook, B. Vance, W. J. Ribbans, S. M. Raleigh, C. Roberts, M. A. Bennett, G. Wang, M. Collins, Y. P. Pitsiladis…

    BMC Genetics 2017 18:4

    Published on: 19 January 2017

  14. Research article

    Genetic dissection of the fatty liver QTL Fl1sa by using congenic mice and identification of candidate genes in the liver and epididymal fat

    Nonalcoholic fatty liver disease (NAFLD) is a multifactorial disease caused by interactions between environmental and genetic factors. The SMXA-5 mouse is a high-fat diet-induced fatty liver model established ...

    Miyako Suzuki, Misato Kobayashi, Tamio Ohno, Shinsaku Kanamori, Soushi Tateishi, Atsushi Murai and Fumihiko Horio

    BMC Genetics 2016 17:145

    Published on: 17 November 2016

  15. Research article

    Development, genetic mapping and QTL association of cotton PHYA, PHYB, and HY5-specific CAPS and dCAPS markers

    Among SNP markers that become increasingly valuable in molecular breeding of crop plants are the CAPS and dCAPS markers derived from the genes of interest. To date, the number of such gene-based markers is sma...

    Fakhriddin N. Kushanov, Alan E. Pepper, John Z. Yu, Zabardast T. Buriev, Shukhrat E. Shermatov, Sukumar Saha, Mauricio Ulloa, Johnie N. Jenkins, Abdusattor Abdukarimov and Ibrokhim Y. Abdurakhmonov

    BMC Genetics 2016 17:141

    Published on: 24 October 2016

  16. Research article

    Quantitative trait loci influencing forking defects in an outbred pedigree of loblolly pine

    The use of wood as an industrial raw material has led to development of plantation forestry, in which trees are planted, managed, and harvested as crops. The productivity of such plantations often exceeds that...

    Jin S. Xiong, Steven E. McKeand, Fikret Isik, Jill Wegrzyn, David B. Neale, Zhao-Bang Zeng, Luciano da Costa e Silva and Ross W. Whetten

    BMC Genetics 2016 17:138

    Published on: 18 October 2016

  17. Research article

    Adrenal cortex expression quantitative trait loci in a German Holstein × Charolais cross

    The importance of the adrenal gland in regard to lactation and reproduction in cattle has been recognized early. Caused by interest in animal welfare and the impact of stress on economically important traits i...

    Bodo Brand, Markus O. Scheinhardt, Juliane Friedrich, Daisy Zimmer, Norbert Reinsch, Siriluck Ponsuksili, Manfred Schwerin and Andreas Ziegler

    BMC Genetics 2016 17:135

    Published on: 6 October 2016

    The Erratum to this article has been published in BMC Genetics 2016 17:148

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