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Complex traits and quantitative genetics

Section edited by Jim Reecy

This section incorporates all aspects of complex trait and quantitative genetics including but not limited to: mapping and association studies, the genetic basis of disease, genetics aspects of breeding and linkage analysis.

Page 1 of 6

  1. Content type: Research article

    Arabian horses are commonly believed to be one of the oldest and the most popular horse breeds in the world, characterized by favourable stamina traits and exercise phenotypes. During intensive training, the r...

    Authors: Katarzyna Ropka-Molik, Monika Stefaniuk-Szmukier, Tomasz Szmatoła, Katarzyna Piórkowska and Monika Bugno-Poniewierska

    Citation: BMC Genetics 2019 20:73

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  2. Content type: Research article

    Yellow lupin (Lupinus luteus L.) is a promising grain legume for productive and sustainable crop rotations. It has the advantages of high tolerance to soil acidity and excellent seed quality, but its current yiel...

    Authors: Muhammad Munir Iqbal, Mark Huynh, Joshua A. Udall, Andrzej Kilian, Kedar N. Adhikari, Jens D. Berger, William Erskine and Matthew N. Nelson

    Citation: BMC Genetics 2019 20:68

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  3. Content type: Research article

    Fruit set after successful pollination is key for the production of sweet cherries, and a low fruit-setting rate is the main problem in production of this crop. As gibberellin treatment can directly induce par...

    Authors: Binbin Wen, Wenliang Song, Mingyue Sun, Min Chen, Qin Mu, Xinhao Zhang, Qijie Wu, Xiude Chen, Dongsheng Gao and Hongyu Wu

    Citation: BMC Genetics 2019 20:65

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  4. Content type: Research article

    Apogamy is a unique asexual reproduction in the ferns, in which somatic cells of gametophytes go through dedifferentiation and then differentiate into haploid sporophytes bypassing fertilization. Restricted to...

    Authors: Qi Fu and Long-qing Chen

    Citation: BMC Genetics 2019 20:55

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  5. Content type: Research article

    Fusarium head blight (FHB) is a problem of great concern in small grain cereals, especially wheat. A quantitative trait locus (QTL) for FHB resistance (FHB_SFI) located on the long arm of chromosome 2D in the spr...

    Authors: Xinkun Hu, Hélène Rocheleau, Curt McCartney, Chiara Biselli, Paolo Bagnaresi, Margaret Balcerzak, George Fedak, Zehong Yan, Giampiero Valè, Shahrokh Khanizadeh and Thérèse Ouellet

    Citation: BMC Genetics 2019 20:47

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  6. Content type: Research article

    The 100-pod fresh weight (PFW), 100-seed fresh weight (SFW), 100-seed dry weight (SDW) and moisture content of fresh seeds (MCFS) at the R6 stage are crucial factors for vegetable soybean yield. However, the g...

    Authors: Xiangnan Li, Xiaoli Zhang, Longming Zhu, Yuanpeng Bu, Xinfang Wang, Xing Zhang, Yang Zhou, Xiaoting Wang, Na Guo, Lijuan Qiu, Jinming Zhao and Han Xing

    Citation: BMC Genetics 2019 20:39

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  7. Content type: Research article

    Aflatoxin contamination caused by Aspergillus flavus is a major constraint to peanut industry worldwide due to its toxicological effects to human and animals. Developing peanut varieties with resistance to seed i...

    Authors: Bolun Yu, Dongxin Huai, Li Huang, Yanping Kang, Xiaoping Ren, Yuning Chen, Xiaojing Zhou, Huaiyong Luo, Nian Liu, Weigang Chen, Yong Lei, Manish K. Pandey, Hari Sudini, Rajeev K. Varshney, Boshou Liao and Huifang Jiang

    Citation: BMC Genetics 2019 20:32

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  8. Content type: Research article

    A genome-wide mapping study using male F2 zinc transporter 7-knockout mice (znt7-KO) and their wild type littermates in a mixed 129P1/ReJ (129P1) and C57BL/6J (B6) background identified a quantitative trait locus...

    Authors: L. Huang, S. Tepaamorndech, C. P. Kirschke, Y. Cai, J. Zhao, Xiaohan Cao and Andrew Rao

    Citation: BMC Genetics 2019 20:19

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  9. Content type: Methodology article

    Genome-wide association studies (GWAS) have been successfully implemented in cattle research and breeding. However, moving from the associations to identify the causal variants and reveal underlying mechanisms...

    Authors: Zexi Cai, Bernt Guldbrandtsen, Mogens Sandø Lund and Goutam Sahana

    Citation: BMC Genetics 2019 20:15

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  10. Content type: Research article

    Traditional single nucleotide polymorphism (SNP) genome-wide association analysis (GWAA) can be inefficient because single SNPs provide limited genetic information about genomic regions. On the other hand, usi...

    Authors: Camila U. Braz, Jeremy F. Taylor, Tiago Bresolin, Rafael Espigolan, Fabieli L. B. Feitosa, Roberto Carvalheiro, Fernando Baldi, Lucia G. de Albuquerque and Henrique N. de Oliveira

    Citation: BMC Genetics 2019 20:8

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  11. Content type: Research article

    Bovine respiratory disease complex (BRDC) is one of the most important sources of loss within the beef cattle industry in the USA. Steps have been taken to reduce the incidence of BRDC through vaccination. Des...

    Authors: L. M. Kramer, M. S. Mayes, E. D. Downey, R. G. Tait Jr, A. Woolums, C. Chase and J. M. Reecy

    Citation: BMC Genetics 2019 20:6

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  12. Content type: Research article

    The number of animals born dead, which includes the number of mummified (NM) and stillborn (NS) animals, is the most important trait to directly quantify the reproductive loss in domestic pigs. In this study, ...

    Authors: Pingxian Wu, Kai Wang, Jie Zhou, Qiang Yang, Xidi Yang, Anan Jiang, Yanzhi Jiang, Mingzhou Li, Li Zhu, Lin Bai, Xuewei Li and Guoqing Tang

    Citation: BMC Genetics 2019 20:4

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  13. Content type: Research article

    Erythropoietin receptor (EPOR) is a functional membrane-bound cytokine receptor. Erythropoietin (EPO) represents an important hematopoietic factor for production, maturation and differentiation of erythroid pr...

    Authors: Barbora Fecková, Patrícia Kimáková, Lenka Ilkovičová, Erika Szentpéteriová, Mária Macejová, Ján Košuth, Anthony Zulli, Nataša Debeljak, Petra Hudler, Karin Jašek, Ivana Kašubová, Peter Kubatka and Peter Solár

    Citation: BMC Genetics 2019 20:1

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  14. Content type: Research article

    In our previous genome-wide association study (GWAS) on the piglet splay leg (PSL) syndrome, the homer scaffolding protein 1 (HOMER1) was detected as a candidate gene. The aim of this work was to further verify t...

    Authors: Sutong Xu, Xingjie Hao, Min Zhang, Kai Wang, Shuaifeng Li, Xing Chen, Liaohan Yang, Lin Hu and Shujun Zhang

    Citation: BMC Genetics 2018 19:110

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  15. Content type: Research article

    The main goal of selection is to achieve genetic gain for a population by choosing the best breeders among a set of selection candidates. Since 2013, the use of a high density genotyping chip (600K Affymetrix®...

    Authors: Florian Herry, Frédéric Hérault, David Picard Druet, Amandine Varenne, Thierry Burlot, Pascale Le Roy and Sophie Allais

    Citation: BMC Genetics 2018 19:108

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  16. Content type: Research article

    Improving feed efficiency in fish is crucial at the economic, social and environmental levels with respect to developing a more sustainable aquaculture. The important contribution of genetic improvement to ach...

    Authors: Hugues de Verdal, Marc Vandeputte, Wagdy Mekkawy, Béatrice Chatain and John A. H. Benzie

    Citation: BMC Genetics 2018 19:105

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  17. Content type: Research article

    Identification of genes underlying production traits is a key aim of the mink research community. Recent availability of genomic tools have opened the possibility for faster genetic progress in mink breeding. ...

    Authors: Zexi Cai, Trine Michelle Villumsen, Torben Asp, Bernt Guldbrandtsen, Goutam Sahana and Mogens Sandø Lund

    Citation: BMC Genetics 2018 19:103

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  18. Content type: Research article

    Congenital skeletal malformations represent a heterogeneous group of disorders affecting bone and cartilage development. In cattle, particular chondrodysplastic forms have been identified in several miniature ...

    Authors: Ann-Kathrin Struck, Claudia Dierks, Marina Braun, Maren Hellige, Anna Wagner, Bernd Oelmaier, Andreas Beineke, Julia Metzger and Ottmar Distl

    Citation: BMC Genetics 2018 19:91

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  19. Content type: Research article

    Approximately 90% of colorectal cancer (CRC) deaths are caused by tumors ability to migrate into the adjacent tissues and metastase into distant organs. More than 40 genes have been causally linked to the deve...

    Authors: Krzysztof Goryca, Maria Kulecka, Agnieszka Paziewska, Michalina Dabrowska, Marta Grzelak, Magdalena Skrzypczak, Krzysztof Ginalski, Andrzej Mroz, Andrzej Rutkowski, Katarzyna Paczkowska, Michal Mikula and Jerzy Ostrowski

    Citation: BMC Genetics 2018 19:85

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  20. Content type: Research article

    Although harness racing is of high economic importance to the global equine industry, significant genomic resources have yet to be applied to mapping harness racing success. To identify genomic regions associa...

    Authors: Brandon D. Velie, Kim Jäderkvist Fegraeus, Marina Solé, Maria K. Rosengren, Knut H. Røed, Carl-Fredrik Ihler, Eric Strand and Gabriella Lindgren

    Citation: BMC Genetics 2018 19:80

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  21. Content type: Research article

    Increasing grain yield is a primary objective of maize breeding. Dissecting the genetic architecture of grain yield furthers genetic improvements to increase yield. Presented here is an association panel compo...

    Authors: Ting Li, Jianzhou Qu, Yahui Wang, Liguo Chang, Kunhui He, Dongwei Guo, Xinghua Zhang, Shutu Xu and Jiquan Xue

    Citation: BMC Genetics 2018 19:63

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  22. Content type: Research article

    The changing climate is altering timing of key fruit ripening processes and increasing the occurrence of fruit defects. To improve our understanding of the genetic control of raspberry fruit development an enh...

    Authors: Christine A. Hackett, Linda Milne, Kay Smith, Pete Hedley, Jenny Morris, Craig G. Simpson, Katharine Preedy and Julie Graham

    Citation: BMC Genetics 2018 19:59

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  23. Content type: Methodology article

    Like glucose-6-phosphate dehydrogenase (G6PD) deficient hemizygous males and homozygous females, heterozygous females could also manifest hemolytic crisis, neonatal hyperbilirubinemia or kernicterus upon expos...

    Authors: Md Tarikul Islam, Suprovath Kumar Sarker, Shezote Talukder, Golam Sarower Bhuyan, Asifuzzaman Rahat, Nafisa Nawal Islam, Hasan Mahmud, Mohammad Amir Hossain, A. K. M. Muraduzzaman, Jakia Rahman, Syeda Kashfi Qadri, Mohammod Shahidullah, Mohammad Abdul Mannan, Sarabon Tahura, Manzoor Hussain, Narayan Saha…

    Citation: BMC Genetics 2018 19:58

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  24. Content type: Research article

    Rolling of leaves (RL) is a phenomenon commonly found in grasses. Morphology of the leaf is an important agronomic trait in field crops especially in rice; therefore, majority of the rice breeders are interest...

    Authors: Beata Myśków, Magdalena Góralska, Natalia Lenarczyk, Ilona Czyczyło-Mysza and Stefan Stojałowski

    Citation: BMC Genetics 2018 19:57

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  25. Content type: Research article

    Many common and relevant diseases affecting equine welfare have yet to be tested regarding structural variants such as copy number variations (CNVs). CNVs make up a substantial proportion of total genetic vari...

    Authors: Anouk Schurink, Vinicius H. da Silva, Brandon D. Velie, Bert W. Dibbits, Richard P. M. A. Crooijmans, Liesbeth Franҫois, Steven Janssens, Anneleen Stinckens, Sarah Blott, Nadine Buys, Gabriella Lindgren and Bart J. Ducro

    Citation: BMC Genetics 2018 19:49

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  26. Content type: Research article

    Photobacteriosis is an infectious disease developed by a Gram-negative bacterium Photobacterium damselae subsp. piscicida (Phdp), which may cause high mortalities (90–100%) in sea bream. Selection and breeding fo...

    Authors: Muhammad L Aslam, Roberta Carraro, Anastasia Bestin, Sophie Cariou, Anna K. Sonesson, Jean-Sébastien Bruant, Pierrick Haffray, Luca Bargelloni and Theo H. E. Meuwissen

    Citation: BMC Genetics 2018 19:43

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  27. Content type: Research article

    Anterior cruciate ligament rupture (ACLR) is a debilitating and potentially life-changing condition in humans, as there is a high prevalence of early-onset osteoarthritis after injury. Identification of high-r...

    Authors: Lauren A. Baker, Guilherme J. M. Rosa, Zhengling Hao, Alexander Piazza, Christopher Hoffman, Emily E. Binversie, Susannah J. Sample and Peter Muir

    Citation: BMC Genetics 2018 19:39

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  28. Content type: Research article

    Currently, genome-wide scans for positive selection signatures in commercial breed have been investigated. However, few studies have focused on selection footprints of indigenous breeds. Laiwu pig is an invalu...

    Authors: Minhui Chen, Jiying Wang, Yanping Wang, Ying Wu, Jinluan Fu and Jian-feng Liu

    Citation: BMC Genetics 2018 19:31

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  29. Content type: Methodology article

    Genome-wide association studies (GWAS) have been successfully implemented in cattle research and breeding. However, moving from the associations to identifying the causal variants and revealing underlying mech...

    Authors: Zexi Cai, Bernt Guldbrandtsen, Mogens Sandø Lund and Goutam Sahana

    Citation: BMC Genetics 2018 19:30

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    The Retraction Note to this article has been published in BMC Genetics 2018 19:111

  30. Content type: Research article

    One of the major impediments to spiny lobster aquaculture is the high cost of hatchery production due to the long and complex larval cycle and poor survival during the many moult stages, especially at metamorp...

    Authors: Nguyen H. Nguyen, Quinn P. Fitzgibbon, Jane Quinn, Greg Smith, Stephen Battaglene and Wayne Knibb

    Citation: BMC Genetics 2018 19:27

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  31. Content type: Research article

    Sweet cherry is consumed widely across the world and provides substantial economic benefits in regions where it is grown. While cherry breeding has been conducted in the Pacific Northwest for over half a centu...

    Authors: Julia Piaskowski, Craig Hardner, Lichun Cai, Yunyang Zhao, Amy Iezzoni and Cameron Peace

    Citation: BMC Genetics 2018 19:23

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  32. Content type: Research article

    During the last two decades, many QTL (quantitative trait locus) mapping experiments in pigs have been conducted using F2 crosses established from two outbred founder breeds. The founder breeds were frequently...

    Authors: Markus Schmid, Robin Wellmann and Jörn Bennewitz

    Citation: BMC Genetics 2018 19:22

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  33. Content type: Research article

    Calving difficulty or dystocia has a great economic impact in the US dairy industry. Reported risk factors associated with calving difficulty are feto-pelvic disproportion, gestation length and conformation. D...

    Authors: Francesco Tiezzi, Maria E. Arceo, John B. Cole and Christian Maltecca

    Citation: BMC Genetics 2018 19:20

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  34. Content type: Research article

    Spotted wilt, caused by tomato spotted wilt virus (TSWV), has been one of major diseases in cultivated peanut grown in the southeastern United States (US) since 1990. Previously a major quantitative trait locus (...

    Authors: Zifan Zhao, Yu-Chien Tseng, Ze Peng, Yolanda Lopez, Charles Y. Chen, Barry L. Tillman, Phat Dang and Jianping Wang

    Citation: BMC Genetics 2018 19:17

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  35. Content type: Research article

    Syringomyelia (SM) is a common condition affecting brachycephalic toy breed dogs and is characterized by the development of fluid-filled cavities within the spinal cord. It is often concurrent with a complex d...

    Authors: Frédéric Ancot, Philippe Lemay, Susan P. Knowler, Karen Kennedy, Sandra Griffiths, Giunio Bruto Cherubini, Jane Sykes, Paul J. J. Mandigers, Guy A. Rouleau, Clare Rusbridge and Zoha Kibar

    Citation: BMC Genetics 2018 19:16

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  36. Content type: Research article

    Patients with long QT syndrome due to rare loss-of-function mutations in the human ether-á-go-go-related gene (hERG) have prolonged QT interval, risk of arrhythmias, increased secretion of insulin and incretins a...

    Authors: Line Engelbrechtsen, Yuvaraj Mahendran, Anna Jonsson, Anette Prior Gjesing, Peter E. Weeke, Marit E. Jørgensen, Kristine Færch, Daniel R. Witte, Jens J. Holst, Torben Jørgensen, Niels Grarup, Oluf Pedersen, Henrik Vestergaard, Signe Torekov, Jørgen K. Kanters and Torben Hansen

    Citation: BMC Genetics 2018 19:15

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  37. Content type: Research article

    Service sire has a considerable impact on reproductive success in dairy cattle. Most gene mapping studies for bull fertility have focused on additive effects, while non-additive effects have been largely ignor...

    Authors: Paula Nicolini, Rocío Amorín, Yi Han and Francisco Peñagaricano

    Citation: BMC Genetics 2018 19:14

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  38. Content type: Research article

    Diversity in crops is fundamental for plant breeding efforts. An accurate assessment of genetic diversity, using molecular markers, such as single nucleotide polymorphism (SNP), must be able to reveal the stru...

    Authors: Martin E. Tagliotti, Sofia I. Deperi, Maria C. Bedogni, Ruofang Zhang, Norma C. Manrique Carpintero, Joseph Coombs, David Douches and Marcelo A. Huarte

    Citation: BMC Genetics 2018 19:8

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  39. Content type: Methodology article

    The development of next-generation sequencing technologies has facilitated the identification of rare variants. Family-based design is commonly used to effectively control for population admixture and substruc...

    Authors: Yumei Li, Yang Xiang, Chao Xu, Hui Shen and Hongwen Deng

    Citation: BMC Genetics 2018 19:7

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  40. Content type: Research article

    Bangladesh lies in the global thalassemia belt, which has a defined mutational hot-spot in the beta-globin gene. The high carrier frequencies of beta-thalassemia trait and hemoglobin E-trait in Bangladesh nece...

    Authors: Md Tarikul Islam, Suprovath Kumar Sarkar, Nusrat Sultana, Mst. Noorjahan Begum, Golam Sarower Bhuyan, Shezote Talukder, A. K. M. Muraduzzaman, Md Alauddin, Mohammad Sazzadul Islam, Pritha Promita Biswas, Aparna Biswas, Syeda Kashfi Qadri, Tahmina Shirin, Bilquis Banu, Salma Sadya, Manzoor Hussain…

    Citation: BMC Genetics 2018 19:1

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  41. Content type: Research article

    Osteoarthritis (OA) is the most common degenerative joint disease afflicting people in the Western world and has a strong genetic influence. The aim of this study was to examine the association of two known fu...

    Authors: Mari Taipale, Svetlana Solovieva, Päivi Leino-Arjas and Minna Männikkö

    Citation: BMC Genetics 2017 18:108

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  42. Content type: Research article

    Coronary artery calcified atherosclerotic plaque (CAC) predicts cardiovascular disease (CVD). Despite exposure to more severe conventional CVD risk factors, African Americans (AAs) are less likely to develop C...

    Authors: Jasmin Divers, Nicholette D. Palmer, Carl D. Langefeld, W. Mark Brown, Lingyi Lu, Pamela J. Hicks, S. Carrie Smith, Jianzhao Xu, James G. Terry, Thomas C. Register, Lynne E. Wagenknecht, John S. Parks, Lijun Ma, Gary C. Chan, Sarah G. Buxbaum, Adolfo Correa…

    Citation: BMC Genetics 2017 18:105

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  43. Content type: Research article

    Repeat breeding, which is defined as cattle failure to conceive after three or more inseminations in the absence of clinical abnormalities, is a substantial problem in cattle breeding. To identify maternal gen...

    Authors: Taichi Arishima, Shinji Sasaki, Tomohiro Isobe, Yoshihisa Ikebata, Shinichi Shimbara, Shogo Ikeda, Keisuke Kawashima, Yutaka Suzuki, Manabu Watanabe, Sumio Sugano, Kazunori Mizoshita and Yoshikazu Sugimoto

    Citation: BMC Genetics 2017 18:103

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  44. Content type: Research article

    Ritodrine, a tocolytic β2-agonist, has been used extensively in Europe and Asia despite its safety concerns. This study was designed to identify associations between β2-adrenergic receptor (ADRB2) polymorphisms a...

    Authors: Jee Eun Chung, Soo An Choi, Han Sung Hwang, Jin Young Park, Kyung Eun Lee, Jeong Yee, Young Ju Kim and Hye Sun Gwak

    Citation: BMC Genetics 2017 18:96

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  45. Content type: Research article

    Recent advances in the mapping of biochemical traits have been reported in Lolium perenne. Although the mapped traits, including individual sugars and fatty acids, contribute greatly towards ruminant productivity...

    Authors: Alexandre Foito, Christine Anne Hackett, Derek Stewart, Janaki Velmurugan, Dan Milbourne, Stephen L. Byrne and Susanne Barth

    Citation: BMC Genetics 2017 18:84

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  46. Content type: Research article

    Understanding the relationship between genetic admixture and performances is crucial for the success of crossbreeding programs. Use of small sets of ancestry informative markers (AIMs) is a cost effective opti...

    Authors: Tesfaye Getachew, Heather J. Huson, Maria Wurzinger, Jörg Burgstaller, Solomon Gizaw, Aynalem Haile, Barbara Rischkowsky, Gottfried Brem, Solomon Antwi Boison, Gábor Mészáros, Ally Okeyo Mwai and Johann Sölkner

    Citation: BMC Genetics 2017 18:80

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