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Complex traits and quantitative genetics

Section edited by Jim Reecy

This section incorporates all aspects of complex trait and quantitative genetics including but not limited to: mapping and association studies, the genetic basis of disease, genetics aspects of breeding and linkage analysis.

Page 1 of 12
  1. Content type: Research article

    Sweet cherry is consumed widely across the world and provides substantial economic benefits in regions where it is grown. While cherry breeding has been conducted in the Pacific Northwest for over half a centu...

    Authors: Julia Piaskowski, Craig Hardner, Lichun Cai, Yunyang Zhao, Amy Iezzoni and Cameron Peace

    Citation: BMC Genetics 2018 19:23

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  2. Content type: Research article

    During the last two decades, many QTL (quantitative trait locus) mapping experiments in pigs have been conducted using F2 crosses established from two outbred founder breeds. The founder breeds were frequently...

    Authors: Markus Schmid, Robin Wellmann and Jörn Bennewitz

    Citation: BMC Genetics 2018 19:22

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  3. Content type: Research article

    Calving difficulty or dystocia has a great economic impact in the US dairy industry. Reported risk factors associated with calving difficulty are feto-pelvic disproportion, gestation length and conformation. D...

    Authors: Francesco Tiezzi, Maria E. Arceo, John B. Cole and Christian Maltecca

    Citation: BMC Genetics 2018 19:20

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  4. Content type: Research article

    Spotted wilt, caused by tomato spotted wilt virus (TSWV), has been one of major diseases in cultivated peanut grown in the southeastern United States (US) since 1990. Previously a major quantitative trait locus (...

    Authors: Zifan Zhao, Yu-Chien Tseng, Ze Peng, Yolanda Lopez, Charles Y. Chen, Barry L. Tillman, Phat Dang and Jianping Wang

    Citation: BMC Genetics 2018 19:17

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  5. Content type: Research article

    Syringomyelia (SM) is a common condition affecting brachycephalic toy breed dogs and is characterized by the development of fluid-filled cavities within the spinal cord. It is often concurrent with a complex d...

    Authors: Frédéric Ancot, Philippe Lemay, Susan P. Knowler, Karen Kennedy, Sandra Griffiths, Giunio Bruto Cherubini, Jane Sykes, Paul J. J. Mandigers, Guy A. Rouleau, Clare Rusbridge and Zoha Kibar

    Citation: BMC Genetics 2018 19:16

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  6. Content type: Research article

    Patients with long QT syndrome due to rare loss-of-function mutations in the human ether-á-go-go-related gene (hERG) have prolonged QT interval, risk of arrhythmias, increased secretion of insulin and incretins a...

    Authors: Line Engelbrechtsen, Yuvaraj Mahendran, Anna Jonsson, Anette Prior Gjesing, Peter E. Weeke, Marit E. Jørgensen, Kristine Færch, Daniel R. Witte, Jens J. Holst, Torben Jørgensen, Niels Grarup, Oluf Pedersen, Henrik Vestergaard, Signe Torekov, Jørgen K. Kanters and Torben Hansen

    Citation: BMC Genetics 2018 19:15

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  7. Content type: Research article

    Service sire has a considerable impact on reproductive success in dairy cattle. Most gene mapping studies for bull fertility have focused on additive effects, while non-additive effects have been largely ignor...

    Authors: Paula Nicolini, Rocío Amorín, Yi Han and Francisco Peñagaricano

    Citation: BMC Genetics 2018 19:14

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  8. Content type: Research article

    Diversity in crops is fundamental for plant breeding efforts. An accurate assessment of genetic diversity, using molecular markers, such as single nucleotide polymorphism (SNP), must be able to reveal the stru...

    Authors: Martin E. Tagliotti, Sofia I. Deperi, Maria C. Bedogni, Ruofang Zhang, Norma C. Manrique Carpintero, Joseph Coombs, David Douches and Marcelo A. Huarte

    Citation: BMC Genetics 2018 19:8

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  9. Content type: Methodology article

    The development of next-generation sequencing technologies has facilitated the identification of rare variants. Family-based design is commonly used to effectively control for population admixture and substruc...

    Authors: Yumei Li, Yang Xiang, Chao Xu, Hui Shen and Hongwen Deng

    Citation: BMC Genetics 2018 19:7

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  10. Content type: Research article

    Bangladesh lies in the global thalassemia belt, which has a defined mutational hot-spot in the beta-globin gene. The high carrier frequencies of beta-thalassemia trait and hemoglobin E-trait in Bangladesh nece...

    Authors: Md Tarikul Islam, Suprovath Kumar Sarkar, Nusrat Sultana, Mst. Noorjahan Begum, Golam Sarower Bhuyan, Shezote Talukder, A. K. M. Muraduzzaman, Md Alauddin, Mohammad Sazzadul Islam, Pritha Promita Biswas, Aparna Biswas, Syeda Kashfi Qadri, Tahmina Shirin, Bilquis Banu, Salma Sadya, Manzoor Hussain…

    Citation: BMC Genetics 2018 19:1

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  11. Content type: Research article

    Osteoarthritis (OA) is the most common degenerative joint disease afflicting people in the Western world and has a strong genetic influence. The aim of this study was to examine the association of two known fu...

    Authors: Mari Taipale, Svetlana Solovieva, Päivi Leino-Arjas and Minna Männikkö

    Citation: BMC Genetics 2017 18:108

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  12. Content type: Research article

    Coronary artery calcified atherosclerotic plaque (CAC) predicts cardiovascular disease (CVD). Despite exposure to more severe conventional CVD risk factors, African Americans (AAs) are less likely to develop C...

    Authors: Jasmin Divers, Nicholette D. Palmer, Carl D. Langefeld, W. Mark Brown, Lingyi Lu, Pamela J. Hicks, S. Carrie Smith, Jianzhao Xu, James G. Terry, Thomas C. Register, Lynne E. Wagenknecht, John S. Parks, Lijun Ma, Gary C. Chan, Sarah G. Buxbaum, Adolfo Correa…

    Citation: BMC Genetics 2017 18:105

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  13. Content type: Research article

    Repeat breeding, which is defined as cattle failure to conceive after three or more inseminations in the absence of clinical abnormalities, is a substantial problem in cattle breeding. To identify maternal gen...

    Authors: Taichi Arishima, Shinji Sasaki, Tomohiro Isobe, Yoshihisa Ikebata, Shinichi Shimbara, Shogo Ikeda, Keisuke Kawashima, Yutaka Suzuki, Manabu Watanabe, Sumio Sugano, Kazunori Mizoshita and Yoshikazu Sugimoto

    Citation: BMC Genetics 2017 18:103

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  14. Content type: Research article

    Ritodrine, a tocolytic β2-agonist, has been used extensively in Europe and Asia despite its safety concerns. This study was designed to identify associations between β2-adrenergic receptor (ADRB2) polymorphisms a...

    Authors: Jee Eun Chung, Soo An Choi, Han Sung Hwang, Jin Young Park, Kyung Eun Lee, Jeong Yee, Young Ju Kim and Hye Sun Gwak

    Citation: BMC Genetics 2017 18:96

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  15. Content type: Research article

    Recent advances in the mapping of biochemical traits have been reported in Lolium perenne. Although the mapped traits, including individual sugars and fatty acids, contribute greatly towards ruminant productivity...

    Authors: Alexandre Foito, Christine Anne Hackett, Derek Stewart, Janaki Velmurugan, Dan Milbourne, Stephen L. Byrne and Susanne Barth

    Citation: BMC Genetics 2017 18:84

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  16. Content type: Research article

    Understanding the relationship between genetic admixture and performances is crucial for the success of crossbreeding programs. Use of small sets of ancestry informative markers (AIMs) is a cost effective opti...

    Authors: Tesfaye Getachew, Heather J. Huson, Maria Wurzinger, Jörg Burgstaller, Solomon Gizaw, Aynalem Haile, Barbara Rischkowsky, Gottfried Brem, Solomon Antwi Boison, Gábor Mészáros, Ally Okeyo Mwai and Johann Sölkner

    Citation: BMC Genetics 2017 18:80

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  17. Content type: Research article

    Surveillance for bovine genetic diseases in Denmark identified a hitherto unreported congenital syndrome occurring among progeny of a Holstein sire used for artificial breeding. A genetic aetiology due to a do...

    Authors: Jørgen S. Agerholm, Fintan J. McEvoy, Steffen Heegaard, Carole Charlier, Vidhya Jagannathan and Cord Drögemüller

    Citation: BMC Genetics 2017 18:74

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  18. Content type: Research article

    Piglet splay leg syndrome (PSL) is one of the most frequent genetic defects, and can cause considerable economic loss in pig production. The present understanding of etiology and pathogenesis of PSL is poor. T...

    Authors: Xingjie Hao, Graham Plastow, Chunyan Zhang, Sutong Xu, Zhiqiu Hu, Tianfu Yang, Kai Wang, Huawei Yang, Xiaoxue Yin, Shili Liu, Zhenghua Wang, Zhiquan Wang and Shujun Zhang

    Citation: BMC Genetics 2017 18:64

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  19. Content type: Research article

    Using a genome-wide association study strategy, our previous study discovered 19 significant single-nucleotide polymorphisms (SNPs) related to semen production traits in Chinese Holstein bulls. Among them, thr...

    Authors: Shuli Liu, Hongwei Yin, Cong Li, Chunhua Qin, Wentao Cai, Mingyue Cao and Shengli Zhang

    Citation: BMC Genetics 2017 18:63

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Page 1 of 12

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