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BMC Genetics

Complex traits and quantitative genetics

Section edited by Jim Reecy

This section incorporates all aspects of complex trait and quantitative genetics including but not limited to: mapping and association studies, the genetic basis of disease, genetics aspects of breeding and linkage analysis.

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  1. Content type: Research article

    Most agronomical traits of crop species are complex traits controlled by multiple genes and affected by environmental factors. While considerable efforts have been made to fine-map and clone major quantitative...

    Authors: Hong-Wei Zhang, Ye-Yang Fan, Yu-Jun Zhu, Jun-Yu Chen, Si-Bin Yu and Jie-Yun Zhuang

    Citation: BMC Genetics 2016 17:98

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  2. Content type: Methodology article

    Selecting chromosome substitution strains (CSSs, also called consomic strains/lines) used in the search for quantitative trait loci (QTLs) consistently requires the identification of the respective phenotypic ...

    Authors: M. Labots, M. C. Laarakker, F. Ohl and H. A. van Lith

    Citation: BMC Genetics 2016 17:95

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  3. Content type: Research article

    The genetic determinism of the calving and suckling performance of beef cows is little known whereas these maternal traits are of major economic importance in beef cattle production systems. This paper aims to...

    Authors: Alexis Michenet, Marine Barbat, Romain Saintilan, Eric Venot and Florence Phocas

    Citation: BMC Genetics 2016 17:88

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  4. Content type: Research article

    The identification of lines resistant to ear diseases is of great importance in maize breeding because such diseases directly interfere with kernel quality and yield. Among these diseases, ear rot disease is w...

    Authors: Jhonathan Pedroso Rigal dos Santos, Luiz Paulo Miranda Pires, Renato Coelho de Castro Vasconcellos, Gabriela Santos Pereira, Renzo Garcia Von Pinho and Marcio Balestre

    Citation: BMC Genetics 2016 17:86

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  5. Content type: Research article

    Genome-wide association studies (GWAS) are a powerful tool for detecting genomic regions explaining variation in phenotype. The objectives of the present study were to identify or refine the positions of genom...

    Authors: Shadi Nayeri, Mehdi Sargolzaei, Mohammed K. Abo-Ismail, Natalie May, Stephen P. Miller, Flavio Schenkel, Stephen S. Moore and Paul Stothard

    Citation: BMC Genetics 2016 17:75

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  6. Content type: Research article

    Fibrotic idiopathic interstitial pneumonias (fIIP) are a group of fatal lung diseases with largely unknown etiology and without definitive treatment other than lung transplant to prolong life. There is strong ...

    Authors: Tasha E. Fingerlin, Weiming Zhang, Ivana V. Yang, Hannah C. Ainsworth, Pamela H. Russell, Rachel Z. Blumhagen, Marvin I. Schwarz, Kevin K. Brown, Mark P. Steele, James E. Loyd, Gregory P. Cosgrove, David A. Lynch, Steve Groshong, Harold R. Collard, Paul J. Wolters, Williamson Z. Bradford…

    Citation: BMC Genetics 2016 17:74

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  7. Content type: Research article

    The SMXA-5 mouse is an animal model of high-fat diet-induced fatty liver. The major QTL for fatty liver, Fl1sa on chromosome 12, was identified in a SM/J × SMXA-5 intercross. The SMXA-5 genome consists of the SM/...

    Authors: Misato Kobayashi, Miyako Suzuki, Tamio Ohno, Kana Tsuzuki, Chie Taguchi, Soushi Tateishi, Teruo Kawada, Young-il Kim, Atsushi Murai and Fumihiko Horio

    Citation: BMC Genetics 2016 17:73

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  8. Content type: Research article

    Tensin2 deficiency results in alterations in podocytes and subsequent glomerular and tubulointerstitial injuries. However, this pathology is critically dependent on genetic background. While the Tensin2-defici...

    Authors: Hayato Sasaki, Junpei Kimura, Ken-Ichi Nagasaki, Kiyoma Marusugi, Takashi Agui and Nobuya Sasaki

    Citation: BMC Genetics 2016 17:69

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  9. Content type: Research article

    Comparing QTL analyses of multiple pair-mating families can provide a better understanding of important allelic variations and distributions. However, most QTL mapping studies in common carp have been based on...

    Authors: Weihua Lv, Xianhu Zheng, Youyi Kuang, Dingchen Cao, Yunqin Yan and Xiaowen Sun

    Citation: BMC Genetics 2016 17:65

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  10. Content type: Research article

    White striping (WS) is an emerging quality defect with adverse consequences for the sensorial, technological, and nutritional qualities of breast meat in broiler chickens. The genetic determinism of this defec...

    Authors: Nabeel Alnahhas, Cécile Berri, Marie Chabault, Pascal Chartrin, Maryse Boulay, Marie Christine Bourin and Elisabeth Le Bihan-Duval

    Citation: BMC Genetics 2016 17:61

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  11. Content type: Research article

    The aim of the present study was to compare the power of single nucleotide polymorphism (SNP)-based genome-wide association study (GWAS) and haplotype-based GWAS for quantitative trait loci (QTL) detection, an...

    Authors: Shuji Sato, Yoshinobu Uemoto, Takashi Kikuchi, Sachiko Egawa, Kimiko Kohira, Tomomi Saito, Hironori Sakuma, Satoshi Miyashita, Shinji Arata, Takatoshi Kojima and Keiichi Suzuki

    Citation: BMC Genetics 2016 17:60

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  12. Content type: Research article

    Hybrid breakdown has been well documented in various species. Relationships between genomic heterozygosity and traits-fitness have been extensively explored especially in the natural populations. But correlati...

    Authors: Baosheng Dai, Huanle Guo, Cong Huang, Xianlong Zhang and Zhongxu Lin

    Citation: BMC Genetics 2016 17:58

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  13. Content type: Research article

    Residual biomass production for fuel conversion represents a unique opportunity to avoid concerns about compromising food supply by using dedicated feedstock crops. Developing tomato varieties suitable for bot...

    Authors: G. Caruso, L. D. Gomez, F. Ferriello, A. Andolfi, C. Borgonuovo, A. Evidente, R. Simister, S. J. McQueen-Mason, D. Carputo, L. Frusciante and M. R. Ercolano

    Citation: BMC Genetics 2016 17:56

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  14. Content type: Research article

    The Nordic Red Cattle consisting of three different populations from Finland, Sweden and Denmark are under a joint breeding value estimation system. The long history of recording of production and health trait...

    Authors: T. Iso-Touru, G. Sahana, B. Guldbrandtsen, M. S. Lund and J. Vilkki

    Citation: BMC Genetics 2016 17:55

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  15. Content type: Research article

    Artificial insemination is widely used in many cattle breeding programs. Semen samples of breeding bulls are collected and closely examined immediately after collection at artificial insemination centers. Only...

    Authors: Hubert Pausch, Heli Venhoranta, Christine Wurmser, Kalle Hakala, Terhi Iso-Touru, Anu Sironen, Rikke K. Vingborg, Hannes Lohi, Lennart Söderquist, Ruedi Fries and Magnus Andersson

    Citation: BMC Genetics 2016 17:49

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  16. Content type: Research article

    Reproductive efficiency has a great impact on the economic success of pork production. Gilts comprise a significant portion of breeding females and gilts that reach puberty earlier tend to stay in the herd lon...

    Authors: Dan J. Nonneman, James F. Schneider, Clay A. Lents, Ralph T. Wiedmann, Jeffrey L. Vallet and Gary A. Rohrer

    Citation: BMC Genetics 2016 17:50

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  17. Content type: Research article

    Although the effect of the fat mass and obesity-associated (FTO) gene on adiposity is well established, there is a lack of evidence whether physical activity (PA) modifies the effect of FTO variants on obesity...

    Authors: Joon Young Kim, Jacob T. DeMenna, Sobha Puppala, Geetha Chittoor, Jennifer Schneider, Ravindranath Duggirala, Lawrence J. Mandarino, Gabriel Q. Shaibi and Dawn K. Coletta

    Citation: BMC Genetics 2016 17:47

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  18. Content type: Research article

    Colorectal cancer is an abnormal tissue development in the colon or rectum. Most of CRCs develop due to somatic mutations, while only a small proportion is caused by inherited mutations. Familial adenomatous p...

    Authors: Alexandra Dorman, Daria Baer, Ian Tomlinson, Richard Mott and Fuad A. Iraqi

    Citation: BMC Genetics 2016 17:46

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    The Erratum to this article has been published in BMC Genetics 2016 17:147

  19. Content type: Research article

    Heritable factors are well known to increase the risk of cancer in families. Known susceptibility genes account for a small proportion of all colorectal cancer cases. The aim of this study was to identify the ...

    Authors: Jessada Thutkawkorapin, Simone Picelli, Vinaykumar Kontham, Tao Liu, Daniel Nilsson and Annika Lindblom

    Citation: BMC Genetics 2016 17:41

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