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Complex traits and quantitative genetics

Section edited by Jim Reecy

This section incorporates all aspects of complex trait and quantitative genetics including but not limited to: mapping and association studies, the genetic basis of disease, genetics aspects of breeding and linkage analysis.

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  1. Content type: Research article

    Identification of genetic variants that are associated with fatty acid composition in beef will enhance our understanding of host genetic influence on the trait and also allow for more effective improvement of...

    Authors: Liuhong Chen, Chinyere Ekine-Dzivenu, Michael Vinsky, John Basarab, Jennifer Aalhus, Mike E. R. Dugan, Carolyn Fitzsimmons, Paul Stothard and Changxi Li

    Citation: BMC Genetics 2015 16:135

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  2. Content type: Research article

    Genetic variance that is not captured by single nucleotide polymorphisms (SNPs) is due to imperfect linkage disequilibrium (LD) between SNPs and quantitative trait loci (QTLs), and the extent of LD between SNP...

    Authors: Yoshinobu Uemoto, Shinji Sasaki, Takatoshi Kojima, Yoshikazu Sugimoto and Toshio Watanabe

    Citation: BMC Genetics 2015 16:134

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  3. Content type: Research article

    Individuals with dyslipidemia often develop type 2 diabetes, and diabetic patients often have dyslipidemia. It remains to be determined whether there are genetic connections between the 2 disorders.

    Authors: Qian Wang, Andrew T. Grainger, Ani Manichaikul, Emily Farber, Suna Onengut-Gumuscu and Weibin Shi

    Citation: BMC Genetics 2015 16:133

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  4. Content type: Research article

    The genetic structure of human populations is the outcome of the combined action of different processes such as demographic dynamics and natural selection. Several efforts toward the characterization of popula...

    Authors: Silvia Parolo, Antonella Lisa, Davide Gentilini, Anna Maria Di Blasio, Simona Barlera, Enrico B. Nicolis, Giorgio B. Boncoraglio, Eugenio A. Parati and Silvia Bione

    Citation: BMC Genetics 2015 16:132

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  5. Content type: Research article

    Adolescence is a sensitive period for weight gain and risky health behaviors, such as smoking. Genome-wide association studies (GWAS) have identified loci contributing to adult body mass index (BMI). Evidence ...

    Authors: Kristin L. Young, Misa Graff, Kari E. North, Andrea S. Richardson, Karen L. Mohlke, Leslie A. Lange, Ethan M. Lange, Kathleen M. Harris and Penny Gordon-Larsen

    Citation: BMC Genetics 2015 16:131

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  6. Content type: Research article

    Formation of the vertebral column is a critical developmental stage in mammals. The strict control of this process has resulted in little variation in number of vertebrae across mammalian species and no variat...

    Authors: Gary A. Rohrer, Dan J. Nonneman, Ralph T. Wiedmann and James F. Schneider

    Citation: BMC Genetics 2015 16:129

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  7. Content type: Research article

    In meta-analyses of genetic association studies, ancestry and ethnicity are not accurately investigated. Ethnicity is usually classified using conventional race/ethnic categories or continental groupings even ...

    Authors: Tania Vásquez-Loarte, Milana Trubnykova and Heinner Guio

    Citation: BMC Genetics 2015 16:128

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  8. Content type: Research article

    Inducing mutations are considered to be an effective way to create novel genetic variations and hence novel agronomical traits in wheat. This study was conducted to assess the genetic differences between Shi41...

    Authors: Xuejiao Cheng, Lingling Chai, Zhaoyan Chen, Lu Xu, Huijie Zhai, Aiju Zhao, Huiru Peng, Yingyin Yao, Mingshan You, Qixin Sun and Zhongfu Ni

    Citation: BMC Genetics 2015 16:127

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  9. Content type: Research article

    Female fertility, a fundamental trait required for animal reproduction, has gradually declined in the last 2 decades in Japanese Black cattle. To identify associated genetic variants in Japanese Black cattle, ...

    Authors: Shinji Sasaki, Takayuki Ibi, Tamako Matsuhashi, Kenji Takeda, Shogo Ikeda, Mayumi Sugimoto and Yoshikazu Sugimoto

    Citation: BMC Genetics 2015 16:123

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  10. Content type: Research article

    Current evidence shows that the CD40–CD40 ligand (CD40–CD40L) system plays a crucial role in the development, progression and outcome of systemic lupus erythematosus (SLE). The aim of this study was to investi...

    Authors: Jian-Ming Chen, Jing Guo, Chuan-Dong Wei, Chun-Fang Wang, Hong-Cheng Luo, Ye-Sheng Wei and Yan Lan

    Citation: BMC Genetics 2015 16:121

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  11. Content type: Research article

    The Nordic Red Cattle (NRC) consists of animls belonging to the Danish Red, Finnish Ayrshire, and Swedish Red breeds. Compared to the Holstein breed, NRC animals are smaller, have a shorter calving interval, lowe...

    Authors: Johanna K. Höglund, Bart Buitenhuis, Bernt Guldbrandtsen, Mogens S. Lund and Goutam Sahana

    Citation: BMC Genetics 2015 16:110

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  12. Content type: Research article

    Bovine mastitis is a typical inflammatory disease causing seriously economic loss. Genome-wide association study (GWAS) can be a powerful method to promote marker assistant selection of this kind of complex di...

    Authors: Xiao Wang, Peipei Ma, Jianfeng Liu, Qin Zhang, Yuan Zhang, Xiangdong Ding, Li Jiang, Yachun Wang, Yi Zhang, Dongxiao Sun, Shengli Zhang, Guosheng Su and Ying Yu

    Citation: BMC Genetics 2015 16:111

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  13. Content type: Research article

    People with prediabetes are at greater risk for heart attack, stroke, kidney disease, vision problems, nerve damage and high blood pressure, compared to those without the disease. Prediabetes is a complex diso...

    Authors: Tran Quang Binh, Nguyen Thi Trung Thu, Pham Tran Phuong, Bui Thi Nhung and Trinh Thi Hong Nhung

    Citation: BMC Genetics 2015 16:107

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  14. Content type: Research article

    Genotype imputation has been used to increase genomic information, allow more animals in genome-wide analyses, and reduce genotyping costs. In Brazilian beef cattle production, many animals are resulting from ...

    Authors: Tatiane C. S. Chud, Ricardo V. Ventura, Flavio S. Schenkel, Roberto Carvalheiro, Marcos E. Buzanskas, Jaqueline O. Rosa, Maurício de Alvarenga Mudadu, Marcos Vinicius G. B. da Silva, Fabiana B. Mokry, Cintia R. Marcondes, Luciana C. A. Regitano and Danísio P. Munari

    Citation: BMC Genetics 2015 16:99

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  15. Content type: Research article

    Limb bone length is an economically important trait in pigs, because it is negatively correlated with backfat thickness, and is also a determinant to the yield of hip and loin. Moreover, abnormal growth of the...

    Authors: Yuanmei Guo, Lijuan Hou, Xufei Zhang, Min Huang, Huirong Mao, Hao Chen, Junwu Ma, Congying Chen, Huashui Ai, Jun Ren and Lusheng Huang

    Citation: BMC Genetics 2015 16:95

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  16. Content type: Research article

    It has been suggested that traits with low heritability, such as fertility, may have proportionately more genetic variation arising from non-additive effects than traits with higher heritability, such as milk ...

    Authors: Hassan Aliloo, Jennie E. Pryce, Oscar González-Recio, Benjamin G. Cocks and Ben J. Hayes

    Citation: BMC Genetics 2015 16:89

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  17. Content type: Correspondence

    In 2003 the Motor Neurone Disease (MND) Association, together with The Wellcome Trust, funded the creation of a national DNA Bank specific for MND. It was anticipated that the DNA Bank would constitute an impo...

    Authors: Lucy Smith, B. C. Cupid, B. G. M. Dickie, A. Al-Chalabi, K. E. Morrison, C. E. Shaw and P. J. Shaw

    Citation: BMC Genetics 2015 16:84

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  18. Content type: Research article

    Previous reports suggested a role for iron and hepcidin in atherosclerosis. Here, we evaluated the causality of these associations from a genetic perspective via (i) a Mendelian randomization (MR) approach, (i...

    Authors: Tessel E. Galesloot, Luc L. Janss, Stephen Burgess, Lambertus A. L. M. Kiemeney, Martin den Heijer, Jacqueline de Graaf, Suzanne Holewijn, Beben Benyamin, John B. Whitfield, Dorine W. Swinkels and Sita H. Vermeulen

    Citation: BMC Genetics 2015 16:79

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  19. Content type: Research article

    Soil phosphorus (P) deficiency is one of the major limiting factors to crop production. The development of crop varieties with improved P use efficiency (PUE) is an important strategy for sustainable agricultu...

    Authors: Kai Wang, Kehui Cui, Guoling Liu, Weibo Xie, Huihui Yu, Junfeng Pan, Jianliang Huang, Lixiao Nie, Farooq Shah and Shaobing Peng

    Citation: BMC Genetics 2014 15:155

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Page 5 of 12

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