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BMC Genetics

Complex traits and quantitative genetics

Section edited by Jim Reecy

This section incorporates all aspects of complex trait and quantitative genetics including but not limited to: mapping and association studies, the genetic basis of disease, genetics aspects of breeding and linkage analysis.

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  1. Content type: Research article

    Female fertility, a fundamental trait required for animal reproduction, has gradually declined in the last 2 decades in Japanese Black cattle. To identify associated genetic variants in Japanese Black cattle, ...

    Authors: Shinji Sasaki, Takayuki Ibi, Tamako Matsuhashi, Kenji Takeda, Shogo Ikeda, Mayumi Sugimoto and Yoshikazu Sugimoto

    Citation: BMC Genetics 2015 16:123

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  2. Content type: Research article

    Current evidence shows that the CD40–CD40 ligand (CD40–CD40L) system plays a crucial role in the development, progression and outcome of systemic lupus erythematosus (SLE). The aim of this study was to investi...

    Authors: Jian-Ming Chen, Jing Guo, Chuan-Dong Wei, Chun-Fang Wang, Hong-Cheng Luo, Ye-Sheng Wei and Yan Lan

    Citation: BMC Genetics 2015 16:121

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  3. Content type: Research article

    The Nordic Red Cattle (NRC) consists of animls belonging to the Danish Red, Finnish Ayrshire, and Swedish Red breeds. Compared to the Holstein breed, NRC animals are smaller, have a shorter calving interval, lowe...

    Authors: Johanna K. Höglund, Bart Buitenhuis, Bernt Guldbrandtsen, Mogens S. Lund and Goutam Sahana

    Citation: BMC Genetics 2015 16:110

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  4. Content type: Research article

    Bovine mastitis is a typical inflammatory disease causing seriously economic loss. Genome-wide association study (GWAS) can be a powerful method to promote marker assistant selection of this kind of complex di...

    Authors: Xiao Wang, Peipei Ma, Jianfeng Liu, Qin Zhang, Yuan Zhang, Xiangdong Ding, Li Jiang, Yachun Wang, Yi Zhang, Dongxiao Sun, Shengli Zhang, Guosheng Su and Ying Yu

    Citation: BMC Genetics 2015 16:111

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  5. Content type: Research article

    People with prediabetes are at greater risk for heart attack, stroke, kidney disease, vision problems, nerve damage and high blood pressure, compared to those without the disease. Prediabetes is a complex diso...

    Authors: Tran Quang Binh, Nguyen Thi Trung Thu, Pham Tran Phuong, Bui Thi Nhung and Trinh Thi Hong Nhung

    Citation: BMC Genetics 2015 16:107

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  6. Content type: Research article

    Genotype imputation has been used to increase genomic information, allow more animals in genome-wide analyses, and reduce genotyping costs. In Brazilian beef cattle production, many animals are resulting from ...

    Authors: Tatiane C. S. Chud, Ricardo V. Ventura, Flavio S. Schenkel, Roberto Carvalheiro, Marcos E. Buzanskas, Jaqueline O. Rosa, Maurício de Alvarenga Mudadu, Marcos Vinicius G. B. da Silva, Fabiana B. Mokry, Cintia R. Marcondes, Luciana C. A. Regitano and Danísio P. Munari

    Citation: BMC Genetics 2015 16:99

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  7. Content type: Research article

    Limb bone length is an economically important trait in pigs, because it is negatively correlated with backfat thickness, and is also a determinant to the yield of hip and loin. Moreover, abnormal growth of the...

    Authors: Yuanmei Guo, Lijuan Hou, Xufei Zhang, Min Huang, Huirong Mao, Hao Chen, Junwu Ma, Congying Chen, Huashui Ai, Jun Ren and Lusheng Huang

    Citation: BMC Genetics 2015 16:95

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  8. Content type: Research article

    It has been suggested that traits with low heritability, such as fertility, may have proportionately more genetic variation arising from non-additive effects than traits with higher heritability, such as milk ...

    Authors: Hassan Aliloo, Jennie E. Pryce, Oscar González-Recio, Benjamin G. Cocks and Ben J. Hayes

    Citation: BMC Genetics 2015 16:89

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  9. Content type: Correspondence

    In 2003 the Motor Neurone Disease (MND) Association, together with The Wellcome Trust, funded the creation of a national DNA Bank specific for MND. It was anticipated that the DNA Bank would constitute an impo...

    Authors: Lucy Smith, B. C. Cupid, B. G. M. Dickie, A. Al-Chalabi, K. E. Morrison, C. E. Shaw and P. J. Shaw

    Citation: BMC Genetics 2015 16:84

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  10. Content type: Research article

    Previous reports suggested a role for iron and hepcidin in atherosclerosis. Here, we evaluated the causality of these associations from a genetic perspective via (i) a Mendelian randomization (MR) approach, (i...

    Authors: Tessel E. Galesloot, Luc L. Janss, Stephen Burgess, Lambertus A. L. M. Kiemeney, Martin den Heijer, Jacqueline de Graaf, Suzanne Holewijn, Beben Benyamin, John B. Whitfield, Dorine W. Swinkels and Sita H. Vermeulen

    Citation: BMC Genetics 2015 16:79

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  11. Content type: Research article

    Soil phosphorus (P) deficiency is one of the major limiting factors to crop production. The development of crop varieties with improved P use efficiency (PUE) is an important strategy for sustainable agricultu...

    Authors: Kai Wang, Kehui Cui, Guoling Liu, Weibo Xie, Huihui Yu, Junfeng Pan, Jianliang Huang, Lixiao Nie, Farooq Shah and Shaobing Peng

    Citation: BMC Genetics 2014 15:155

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  12. Content type: Research article

    Genotype imputation is an important tool for whole-genome prediction as it allows cost reduction of individual genotyping. However, benefits of genotype imputation have been evaluated mostly for linear additiv...

    Authors: Vivian PS Felipe, Hayrettin Okut, Daniel Gianola, Martinho A Silva and Guilherme JM Rosa

    Citation: BMC Genetics 2014 15:149

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  13. Content type: Research article

    The ZFHX3 gene, located in Chromosome 16q22.3, codes for a transcription factor which is widely expressed in human tissues. Genome-wide studies have identified associations between variants within the gene and Ka...

    Authors: Ruairidh I R Martin, W Andrew Owens, Michael S Cunnington, Bongani M Mayosi, Mauro Santibáñez Koref and Bernard D Keavney

    Citation: BMC Genetics 2014 15:136

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  14. Content type: Research article

    Myeloproliferative neoplasms (MPNs) are a group of haematological malignancies that can be characterised by a somatic mutation (JAK2V617F). This mutation causes the bone marrow to produce excessive blood cells an...

    Authors: Su Pin Koh, Shea Ping Yip, Kwok Kuen Lee, Chi Chung Chan, Sze Man Lau, Chi Shan Kho, Chi Kuen Lau, Shek Ying Lin, Yat Ming Lau, Lap Gate Wong, Ka Leung Au, Kit Fai Wong, Raymond W Chu, Pui Hung Yu, Eudora YD Chow, Kate FS Leung…

    Citation: BMC Genetics 2014 15:147

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  15. Content type: Research article

    Global trade has ensured that the ornamental horticulture continues to grow worldwide, with rose hybrids being the most economically important genus (Rosa x hybrida). Due to changes in global trade and an increas...

    Authors: Virginia W Gitonga, Carole FS Koning-Boucoiran, Kathryn Verlinden, Oene Dolstra, Richard GF Visser, Chris Maliepaard and Frans A Krens

    Citation: BMC Genetics 2014 15:146

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  16. Content type: Research article

    Linkage maps are essential tools for the study of several topics in genome biology. High density linkage maps for the porcine autosomes have been constructed exploiting the high density data provided by the Po...

    Authors: Ana I Fernández, María Muñoz, Estefânia Alves, Josep María Folch, Jose Luis Noguera, Miguel Pérez Enciso, Maria del Carmen Rodríguez and Luis Silió

    Citation: BMC Genetics 2014 15:148

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  17. Content type: Research article

    Toll-like receptors play a key role in innate immunity by recognizing pathogens and activating appropriate responses. Pathogens express several signal molecules (pathogen-associated molecular patterns, PAMPs) ...

    Authors: Flora Alfano, Simone Peletto, Maria Gabriella Lucibelli, Giorgia Borriello, Giovanna Urciuolo, Maria Grazia Maniaci, Rosanna Desiato, Michela Tarantino, Amalia Barone, Paolo Pasquali, Pier Luigi Acutis and Giorgio Galiero

    Citation: BMC Genetics 2014 15:139

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  18. Content type: Research article

    Molecular diagnosis of Inherited Retinal Dystrophies (IRD) has long been challenging due to the extensive clinical and genetic heterogeneity present in this group of disorders. Here, we describe the clinical a...

    Authors: Cristina Méndez-Vidal, Nereida Bravo-Gil, María González-del Pozo, Alicia Vela-Boza, Joaquín Dopazo, Salud Borrego and Guillermo Antiñolo

    Citation: BMC Genetics 2014 15:143

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  19. Content type: Research article

    Peanut is one of the major source for human consumption worldwide and its seed contain approximately 50% oil. Improvement of oil content and quality traits (high oleic and low linoleic acid) in peanut could be...

    Authors: Manish K Pandey, Ming Li Wang, Lixian Qiao, Suping Feng, Pawan Khera, Hui Wang, Brandon Tonnis, Noelle A Barkley, Jianping Wang, C Corley Holbrook, Albert K Culbreath, Rajeev K Varshney and Baozhu Guo

    Citation: BMC Genetics 2014 15:133

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