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Complex traits and quantitative genetics

Section edited by Jim Reecy

This section incorporates all aspects of complex trait and quantitative genetics including but not limited to: mapping and association studies, the genetic basis of disease, genetics aspects of breeding and linkage analysis.

Page 5 of 6

  1. Content type: Research article

    Meat quality involves many traits, such as marbling, tenderness, juiciness, and backfat thickness, all of which require attention from livestock producers. Backfat thickness improvement by means of traditional...

    Authors: Fabiana Barichello Mokry, Roberto Hiroshi Higa, Maurício de Alvarenga Mudadu, Andressa Oliveira de Lima, Sarah Laguna Conceição Meirelles, Marcos Vinicius Gualberto Barbosa da Silva, Fernando Flores Cardoso, Maurício Morgado de Oliveira, Ismael Urbinati, Simone Cristina Méo Niciura, Rymer Ramiz Tullio, Maurício Mello de Alencar and Luciana Correia de Almeida Regitano

    Citation: BMC Genetics 2013 14:47

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  2. Content type: Research article

    Porcine chromosome X harbors four QTL strongly affecting backfat thickness (BFT), ham weight (HW), intramuscular fat content (IMF) and loin eye area (LEA). The confidence intervals (CI) of these QTL overlap an...

    Authors: Junwu Ma, Hélène Gilbert, Nathalie Iannuccelli, Yanyu Duan, Beili Guo, Weibing Huang, Huanban Ma, Juliette Riquet, Jean-Pierre Bidanel, Lusheng Huang and Denis Milan

    Citation: BMC Genetics 2013 14:46

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  3. Content type: Research article

    The Belgian Malinois dog breed (MAL) is frequently used in law enforcement and military environments. Owners have reported seizures and unpredictable behavioral changes including dogs’ eyes “glazing over,” dog...

    Authors: Lisa Lit, Janelle M Belanger, Debby Boehm, Nathan Lybarger, Anouck Haverbeke, Claire Diederich and Anita M Oberbauer

    Citation: BMC Genetics 2013 14:45

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  4. Content type: Research article

    Congenital heart defects (CHD) is the most common cause of death from a congenital structure abnormality in newborns and is often associated with fetal loss. There are many types of CHD. Human genetic studies ...

    Authors: Antònia Flaquer, Clemens Baumbach, Estefania Piñero, Fernando García Algas, María Angeles de la Fuente Sanchez, Jordi Rosell, Jorge Toquero, Luis Alonso-Pulpon, Pablo Garcia-Pavia, Konstantin Strauch and Damian Heine-Suñer

    Citation: BMC Genetics 2013 14:44

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  5. Content type: Research article

    Calving efficiency can be described as the measure of a cow’s ability to produce viable offspring within a specific period of time. This trait is crucial in beef cattle because calves are necessary both for th...

    Authors: Shinji Sasaki, Takayuki Ibi, Toshio Watanabe, Tamako Matsuhashi, Shogo Ikeda and Yoshikazu Sugimoto

    Citation: BMC Genetics 2013 14:41

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  6. Content type: Research article

    Since the first outbreak in Indonesia in 1926, Newcastle disease has become one of the most common and contagious bird diseases throughout the world. To date, enhancing host antibody response by vaccination re...

    Authors: Chenglong Luo, Hao Qu, Jie Ma, Jie Wang, Chunyu Li, Chunfen Yang, Xiaoxiang Hu, Ning Li and Dingming Shu

    Citation: BMC Genetics 2013 14:42

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  7. Content type: Research article

    The honey bee is an economically important species. With a rapid decline of the honey bee population, it is necessary to implement an improved genetic evaluation methodology. In this study, we investigated the...

    Authors: Pooja Gupta, Norbert Reinsch, Andreas Spötter, Tim Conrad and Kaspar Bienefeld

    Citation: BMC Genetics 2013 14:36

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  8. Content type: Research article

    Mice carrying the A y allele at the agouti locus become obese and are heavier than their non-A y littermates. However, this does not h...

    Authors: Jun-ichi Suto and Kunio Satou

    Citation: BMC Genetics 2013 14:35

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  9. Content type: Research article

    High-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), and triglyceride (TG) levels are influenced by both genes and the environment. Genome-wide association studies (GWAS) ...

    Authors: Kira C Taylor, Cara L Carty, Logan Dumitrescu, Petra Bůžková, Shelley A Cole, Lucia Hindorff, Fred R Schumacher, Lynne R Wilkens, Ralph V Shohet, P Miguel Quibrera, Karen C Johnson, Brian E Henderson, Jeff Haessler, Nora Franceschini, Charles B Eaton, David J Duggan…

    Citation: BMC Genetics 2013 14:33

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  10. Content type: Research article

    Because of the role of inflammation in preterm birth (PTB), polymorphisms in and near the interleukin-6 gene (IL6) have been association study targets. Several previous studies have assessed the association betwe...

    Authors: Wilfred Wu, Erin A S Clark, Gregory J Stoddard, W Scott Watkins, M Sean Esplin, Tracy A Manuck, Jinchuan Xing, Michael W Varner and Lynn B Jorde

    Citation: BMC Genetics 2013 14:30

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  11. Content type: Research article

    Infectious Bovine Keratoconjunctivitis (IBK) in beef cattle, commonly known as pinkeye, is a bacterial disease caused by M o r a x e l l a bovis. IBK is characterized by excessive tearing and ulceration of the co...

    Authors: Kadir Kizilkaya, Richard G Tait, Dorian J Garrick, Rohan L Fernando and James M Reecy

    Citation: BMC Genetics 2013 14:23

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  12. Content type: Research article

    Comparisons of quantitative trait loci (QTL) for growth and parameters of growth curves assist in understanding the genetics and ultimately the physiology of growth. Records of body weight at 3, 6, 12, 24, 48 ...

    Authors: Baitsi K Podisi, Sara A Knott, David W Burt and Paul M Hocking

    Citation: BMC Genetics 2013 14:22

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  13. Content type: Research article

    Hip dysplasia remains one of the most serious hereditary diseases occurring in dogs despite long-standing evaluation schemes designed to aid selection for healthy joints. Many researchers have recommended the ...

    Authors: Thomas W Lewis, Sarah C Blott and John A Woolliams

    Citation: BMC Genetics 2013 14:16

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  14. Content type: Research article

    Selection for grain yield under drought is an efficient criterion for improving the drought tolerance of rice. Recently, some drought-tolerant rice varieties have been developed using this selection criterion ...

    Authors: Krishna Kumar Mishra, Prashant Vikram, Ram Baran Yadaw, BP Mallikarjuna Swamy, Shalabh Dixit, Ma Teresa Sta Cruz, Paul Maturan, Shailesh Marker and Arvind Kumar

    Citation: BMC Genetics 2013 14:12

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  15. Content type: Research article

    Genome-wide association studies (GWAS) have recently identified many new genetic variants associated with the development of type 2 diabetes. Many of these variants are in introns of known genes or between kno...

    Authors: Maggie M Ho, Piriya Yoganathan, Kwan Yi Chu, Subashini Karunakaran, James D Johnson and Susanne M Clee

    Citation: BMC Genetics 2013 14:10

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  16. Content type: Research article

    Knowledge of genetic markers that are correlated to stress tolerance may improve spatial mapping of reef vulnerability and can inform restoration efforts, including the choice of genotypes for breeding and res...

    Authors: Petra Lundgren, Juan C Vera, Lesa Peplow, Stephanie Manel and Madeleine JH van Oppen

    Citation: BMC Genetics 2013 14:9

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  17. Content type: Research article

    Asparagus bean (Vigna. unguiculata. ssp sesquipedalis) is a subspecies and special vegetable type of cowpea (Vigna. unguiculata L. Walp.) important in Asia. Genetic basis of horticulturally important traits of as...

    Authors: Pei Xu, Xiaohua Wu, Baogen Wang, Tingting Hu, Zhongfu Lu, Yonghua Liu, Dehui Qin, Sha Wang and Guojing Li

    Citation: BMC Genetics 2013 14:4

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  18. Content type: Research article

    This study focused on the dynamics of genome-wide effects on five milk production and eight fertility traits as well as genetic correlations between the traits. For 2,405 Holstein Friesian bulls, estimated bre...

    Authors: Eva M Strucken, Ralf H Bortfeldt, Jens Tetens, Georg Thaller and Gudrun A Brockmann

    Citation: BMC Genetics 2012 13:108

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  19. Content type: Research article

    Map-based cloning of quantitative trait loci (QTLs) in polyploidy crop species remains a challenge due to the complexity of their genome structures. QTLs for seed weight in B. napus have been identified, but info...

    Authors: Guangqin Cai, Qingyong Yang, Qian Yang, Zhenxing Zhao, Hao Chen, Jian Wu, Chuchuan Fan and Yongming Zhou

    Citation: BMC Genetics 2012 13:105

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  20. Content type: Research article

    About 9% of the offspring of a clinically healthy Piétrain boar named ‘Campus’ showed a progressive postural tremor called Campus syndrome (CPS). Extensive backcross experiments suggested a dominant mode of in...

    Authors: Leonardo Murgiano, Imke Tammen, Barbara Harlizius and Cord Drögemüller

    Citation: BMC Genetics 2012 13:99

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  21. Content type: Research article

    In crop species, QTL analysis is commonly used for identification of factors contributing to variation of agronomically important traits. As an important pasture species, a large number of QTLs have been repor...

    Authors: Hiroshi Shinozuka, Noel OI Cogan, German C Spangenberg and John W Forster

    Citation: BMC Genetics 2012 13:101

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  22. Content type: Research article

    Genomic analyses have the potential to impact selective breeding programs by identifying markers that serve as proxies for traits which are expensive or difficult to measure. Also, identifying genes affecting ...

    Authors: Caird E Rexroad III, Roger L Vallejo, Sixin Liu, Yniv Palti and Gregory M Weber

    Citation: BMC Genetics 2012 13:97

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  23. Content type: Research article

    In this study we perform a genome-wide association study (GWAS) for bovine milk fatty acids from summer milk samples. This study replicates a previous study where we performed a GWAS for bovine milk fatty acid...

    Authors: Aniek C Bouwman, Marleen HPW Visker, Johan AM van Arendonk and Henk Bovenhuis

    Citation: BMC Genetics 2012 13:93

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  24. Content type: Research article

    Slow-growing lines are widely used in France for the production of high quality free-range chickens. While such production is mainly dedicated to the whole carcass market, new prospects are opening up for the ...

    Authors: Marie Chabault, Elisabeth Baéza, Vérane Gigaud, Pascal Chartrin, Hervé Chapuis, Maryse Boulay, Cécile Arnould, François D’Abbadie, Cécile Berri and Elisabeth Le Bihan-Duval

    Citation: BMC Genetics 2012 13:90

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  25. Content type: Research article

    In this report we studied the genetic regulation of juvenile development of wildbarley introgression lines (S42ILs) under two contrasting hydroponic nitrogen (N)supplies. Ten shoot and root related traits were...

    Authors: Astrid Hoffmann, Andreas Maurer and Klaus Pillen

    Citation: BMC Genetics 2012 13:88

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  26. Content type: Research article

    Trypanosomosis, a protozoal disease affecting livestock, transmitted by Glossina (tsetse) flies is a major constraint to agricultural production in Sub-Saharan Africa. It is accepted that utilization of the nativ...

    Authors: Caleb O Orenge, Leonard Munga, Charles N Kimwele, Steve Kemp, Abraham Korol, John P Gibson, Olivier Hanotte and Morris Soller

    Citation: BMC Genetics 2012 13:87

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  27. Content type: Research article

    Pigeonpea is an important grain legume of the semi-arid tropics and sub-tropical regions where it plays a crucial role in the food and nutritional security of the people. The average productivity of pigeonpea ...

    Authors: Giriraj Kumawat, Ranjeet S Raje, Shefali Bhutani, Jitendra K Pal, Amitha SVCR Mithra, Kishor Gaikwad, Tilak R Sharma and Nagendra K Singh

    Citation: BMC Genetics 2012 13:84

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  28. Content type: Research article

    The genome-wide association study (GWAS) is a useful approach to identify genes affecting economically important traits in dairy cattle. Here, we report the results from a GWAS based on high-density SNP genoty...

    Authors: Jiazhong Guo, Hossein Jorjani and Örjan Carlborg

    Citation: BMC Genetics 2012 13:82

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  29. Content type: Research article

    We previously established a congenic mouse strain with TALLYHO/Jng (TH) donor segment on chromosome 6 in a C57BL/6 (B6) background that harbors an obesity quantitative trait locus, tabw2. The B6.TH-tabw2 congenic...

    Authors: Taryn P Stewart, Xia Mao, Maha N Aqqad, Deon Uffort, Kristy D Dillon, Arnold M Saxton and Jung Han Kim

    Citation: BMC Genetics 2012 13:81

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  30. Content type: Research article

    Recently, genome-wide association studies identified a pleiotropic gene locus, ABO, as being significantly associated with hematological traits. To confirm the effects of ABO on hematological traits, we examined ...

    Authors: Kyung-Won Hong, Sanghoon Moon, Young Jin Kim, Yun Kyoung Kim, Dong-Joon Kim, Cheong-sik Kim, Sung Soo Kim and Bong-Jo Kim

    Citation: BMC Genetics 2012 13:78

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  31. Content type: Research article

    There is often a pronounced disagreement between results obtained from different genome-wide association studies in cattle. There are multiple reasons for this disagreement. Particularly the presence of false ...

    Authors: Johanna K Höglund, Bernt Guldbrandtsen, Mogens S Lund and Goutam Sahana

    Citation: BMC Genetics 2012 13:71

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  32. Content type: Research article

    A synthetic doubled-haploid hexaploid wheat population, SynDH1, derived from the spontaneous chromosome doubling of triploid F1 hybrid plants obtained from the cross of hybrids Triticum turgidum ssp. durum line L...

    Authors: Li Zhang, Jiang-Tao Luo, Ming Hao, Lian-Quan Zhang, Zhong-Wei Yuan, Ze-Hong Yan, Ya-Xi Liu, Bo Zhang, Bao-Long Liu, Chun-Ji Liu, Huai-Gang Zhang, You-Liang Zheng and Deng-Cai Liu

    Citation: BMC Genetics 2012 13:69

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  33. Content type: Research article

    The abscisic acid (ABA) pathway plays an important role in the plants’ reaction to drought stress and ABA-stress response (Asr) genes are important in controlling this process. In this sense, we accessed nucleoti...

    Authors: Andrés J Cortés, M Carolina Chavarro, Santiago Madriñán, Dominique This and Matthew W Blair

    Citation: BMC Genetics 2012 13:58

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  34. Content type: Research article

    Neonatal cerebellar cortical degeneration is a neurodegenerative disease described in several canine breeds including the Beagle. Affected Beagles are unable to ambulate normally from the onset of walking and ...

    Authors: Oliver P Forman, Luisa De Risio, Jennifer Stewart, Cathryn S Mellersh and Elsa Beltran

    Citation: BMC Genetics 2012 13:55

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  35. Content type: Research article

    The turbot (Scophthalmus maximus) is a relevant species in European aquaculture. The small turbot genome provides a source for genomics strategies to use in order to understand the genetic basis of productive tra...

    Authors: Carmen Bouza, Miguel Hermida, Belén G Pardo, Manuel Vera, Carlos Fernández, Roberto de la Herrán, Rafael Navajas-Pérez, José Antonio Álvarez-Dios, Antonio Gómez-Tato and Paulino Martínez

    Citation: BMC Genetics 2012 13:54

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  36. Content type: Research article

    The mammalian cochlea receives and analyzes sound at specific places along the cochlea coil, commonly referred to as the tonotopic map. Although much is known about the cell-level molecular defects responsible...

    Authors: James M Keller and Konrad Noben-Trauth

    Citation: BMC Genetics 2012 13:32

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  37. Content type: Research article

    Coronary artery disease (CAD), and one of its intermediate risk factors, dyslipidemia, possess a demonstrable genetic component, although the genetic architecture is incompletely defined. We previously reporte...

    Authors: Daniel K Nolan, Beth Sutton, Carol Haynes, Jessica Johnson, Jacqueline Sebek, Elaine Dowdy, David Crosslin, David Crossman, Michael H Sketch Jr, Christopher B Granger, David Seo, Pascal Goldschmidt-Clermont, William E Kraus, Simon G Gregory, Elizabeth R Hauser and Svati H Shah

    Citation: BMC Genetics 2012 13:12

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  38. Content type: Research article

    Phytophthora infestans (Mont.) de Bary, the causal organism of late blight, is economically the most important pathogen of potato and resistance against it has been one of the primary goals of potato breeding. So...

    Authors: Jadwiga Śliwka, Henryka Jakuczun, Marcin Chmielarz, Agnieszka Hara-Skrzypiec, Iga Tomczyńska, Andrzej Kilian and Ewa Zimnoch-Guzowska

    Citation: BMC Genetics 2012 13:11

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  39. Content type: Research article

    Identification of genomic regions that have been targets of selection for phenotypic traits is one of the most important and challenging areas of research in animal genetics. However, currently there are relat...

    Authors: Mohammad Hossein Moradi, Ardeshir Nejati-Javaremi, Mohammad Moradi-Shahrbabak, Ken G Dodds and John C McEwan

    Citation: BMC Genetics 2012 13:10

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  40. Content type: Research article

    In a previously reported genome-wide association study based on a high-density bovine SNP genotyping array, 8 SNP were nominally associated (P ≤ 0.003) with average daily gain (ADG) and 3 of these were also assoc...

    Authors: Amanda K Lindholm-Perry, Andrea K Sexten, Larry A Kuehn, Timothy PL Smith, D Andy King, Steven D Shackelford, Tommy L Wheeler, Calvin L Ferrell, Thomas G Jenkins, Warren M Snelling and Harvey C Freetly

    Citation: BMC Genetics 2011 12:103

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  41. Content type: Research article

    The intramuscular fat deposition and the fatty acid profiles of beef affect meat quality. High proportions of unsaturated fatty acids are related to beef flavor and are beneficial for the nutritional value of ...

    Authors: Philipp Widmann, Karin Nuernberg, Christa Kuehn and Rosemarie Weikard

    Citation: BMC Genetics 2011 12:96

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  42. Content type: Research article

    High recombination rates have previously been detected in two groups of eusocial insects; honeybees and ants. In this study we estimate recombination rate in a eusocial wasp Vespula vulgaris that represents a thi...

    Authors: Anu Sirviö, J Spencer Johnston, Tom Wenseleers and Pekka Pamilo

    Citation: BMC Genetics 2011 12:95

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  43. Content type: Research article

    Reproductive traits, such as prolificacy, are of great interest to the pig industry. Better understanding of their genetic architecture should help to increase the efficiency of pig productivity through the im...

    Authors: Ingrid Balcells, Anna Castelló, Anna Mercadé, José L Noguera, Amanda Fernández-Rodríguez, Armand Sànchez and Anna Tomàs

    Citation: BMC Genetics 2011 12:93

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  44. Content type: Research article

    Many QTL have been detected in pigs, but very few of them have been fine-mapped up to the causal mutation. On SSC2, the IGF2-intron3-G3072A mutation has been described as the causative polymorphism for a QTL unde...

    Authors: Flavie Tortereau, Marie-Pierre Sanchez, Katia Fève, Hélène Gilbert, Nathalie Iannuccelli, Yvon Billon, Denis Milan, Jean-Pierre Bidanel and Juliette Riquet

    Citation: BMC Genetics 2011 12:92

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  45. Content type: Research article

    Drought is one of the most important abiotic stresses causing drastic reductions in yield in rainfed rice environments. The suitability of grain yield (GY) under drought as a selection criterion has been repor...

    Authors: Prashant Vikram, BP Mallikarjuna Swamy, Shalabh Dixit, Helal Uddin Ahmed, Ma Teresa Sta Cruz, Alok Kumar Singh and Arvind Kumar

    Citation: BMC Genetics 2011 12:89

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  46. Content type: Research article

    It is widely accepted that genetic variability might explain a large part of the observed heterogeneity in aerobic capacity and its response to training. Significant associations between polymorphisms of diffe...

    Authors: Tom Thomaes, Martine Thomis, Steven Onkelinx, Robert Fagard, Gert Matthijs, Roselien Buys, Dirk Schepers, Véronique Cornelissen and Luc Vanhees

    Citation: BMC Genetics 2011 12:84

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