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Statistical and computational genetics

Section edited by Rongling Wu

This section incorporates all aspects of statistical and computational genetics, including but not limited to: methods and applications for the analysis of all types of genetic data.

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  1. Content type: Research article

    F2 resource populations have been used extensively to map QTL segregating between pig breeds. A limitation associated with the use of these resource populations for fine mapping of QTL is the reduced number of f....

    Authors: Jose L Gualdrón Duarte, Ronald O Bates, Catherine W Ernst, Nancy E Raney, Rodolfo JC Cantet and Juan P Steibel

    Citation: BMC Genetics 2013 14:38

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  2. Content type: Methodology article

    For genetic association studies in designs of unrelated individuals, current statistical methodology typically models the phenotype of interest as a function of the genotype and assumes a known statistical mod...

    Authors: Sharon Lutz, Wai-Ki Yip, John Hokanson, Nan Laird and Christoph Lange

    Citation: BMC Genetics 2013 14:13

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  3. Content type: Research article

    Recombination rates vary at the level of the species, population and individual. Now recognized as a transient feature of the genome, recombination rates at a given locus can change markedly over time. Existin...

    Authors: Murray P Cox, Barbara R Holland, Matthew C Wilkins and Jan Schmid

    Citation: BMC Genetics 2013 14:11

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  4. Content type: Research article

    Genotype imputation is a cost efficient alternative to use of high density genotypes for implementing genomic selection. The objective of this study was to investigate variables affecting imputation accuracy f...

    Authors: Yvonne M Badke, Ronald O Bates, Catherine W Ernst, Clint Schwab, Justin Fix, Curtis P Van Tassell and Juan P Steibel

    Citation: BMC Genetics 2013 14:8

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  5. Content type: Methodology article

    The evaluation of associations between genotypes and diseases in a case-control framework plays an important role in genetic epidemiology. This paper focuses on the evaluation of the homogeneity of both genoty...

    Authors: Rafael Izbicki, Victor Fossaluza, Ana Gabriela Hounie, Eduardo Yoshio Nakano and Carlos Alberto de Bragança Pereira

    Citation: BMC Genetics 2012 13:103

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  6. Content type: Correspondence

    Mathematical models of viral dynamics in vivo provide incredible insights into the mechanisms for the nonlinear interaction between virus and host cell populations, the dynamics of viral drug resistance, and the ...

    Authors: Wei Hou, Yihan Sui, Zhong Wang, Yaqun Wang, Ningtao Wang, Jingyuan Liu, Yao Li, Maureen Goodenow, Li Yin, Zuoheng Wang and Rongling Wu

    Citation: BMC Genetics 2012 13:91

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  7. Content type: Software

    Accurate genetic maps are the cornerstones of genetic discovery, but their construction can be hampered by missing parental genotype information. Inference of parental haplotypes and correction of phase errors...

    Authors: Zhiqiu Hu, Jeffrey D Ehlers, Philip A Roberts, Timothy J Close, Mitchell R Lucas, Steve Wanamaker and Shizhong Xu

    Citation: BMC Genetics 2012 13:9

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  8. Content type: Research article

    The advent of high throughput sequencing technology has enabled the 1000 Genomes Project Pilot 3 to generate complete sequence data for more than 906 genes and 8,140 exons representing 697 subjects. The 1000 G...

    Authors: Xinyi Cindy Zhang, Bo Zhang, Shuying Sue Li, Xin Huang, John A Hansen and Lue Ping Zhao

    Citation: BMC Genetics 2012 13:6

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  9. Content type: Methodology article

    Hundreds of new loci have been discovered by genome-wide association studies of human traits. These studies mostly focused on associations between single locus and a trait. Interactions between genes and betwe...

    Authors: Maksim V Struchalin, Najaf Amin, Paul HC Eilers, Cornelia M van Duijn and Yurii S Aulchenko

    Citation: BMC Genetics 2012 13:4

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