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  1. Content type: Research article

    Osteoarthritis (OA) is the most common degenerative joint disease afflicting people in the Western world and has a strong genetic influence. The aim of this study was to examine the association of two known fu...

    Authors: Mari Taipale, Svetlana Solovieva, Päivi Leino-Arjas and Minna Männikkö

    Citation: BMC Genetics 2017 18:108

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  2. Content type: Research article

    Genomic selection (GS) uses genome-wide markers as an attempt to accelerate genetic gain in breeding programs of both animals and plants. This approach is particularly useful for perennial crops such as oil pa...

    Authors: Qi Bin Kwong, Chee Keng Teh, Ai Ling Ong, Fook Tim Chew, Sean Mayes, Harikrishna Kulaveerasingam, Martti Tammi, Suat Hui Yeoh, David Ross Appleton and Jennifer Ann Harikrishna

    Citation: BMC Genetics 2017 18:107

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  3. Content type: Research article

    Coronary artery calcified atherosclerotic plaque (CAC) predicts cardiovascular disease (CVD). Despite exposure to more severe conventional CVD risk factors, African Americans (AAs) are less likely to develop C...

    Authors: Jasmin Divers, Nicholette D. Palmer, Carl D. Langefeld, W. Mark Brown, Lingyi Lu, Pamela J. Hicks, S. Carrie Smith, Jianzhao Xu, James G. Terry, Thomas C. Register, Lynne E. Wagenknecht, John S. Parks, Lijun Ma, Gary C. Chan, Sarah G. Buxbaum, Adolfo Correa…

    Citation: BMC Genetics 2017 18:105

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  4. Content type: Research article

    Repeat breeding, which is defined as cattle failure to conceive after three or more inseminations in the absence of clinical abnormalities, is a substantial problem in cattle breeding. To identify maternal gen...

    Authors: Taichi Arishima, Shinji Sasaki, Tomohiro Isobe, Yoshihisa Ikebata, Shinichi Shimbara, Shogo Ikeda, Keisuke Kawashima, Yutaka Suzuki, Manabu Watanabe, Sumio Sugano, Kazunori Mizoshita and Yoshikazu Sugimoto

    Citation: BMC Genetics 2017 18:103

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  5. Content type: Methodology article

    When testing for SNP (single nucleotide polymorphism) associations in related individuals, observations are not independent. Simple linear regression assuming independent normally distributed residuals results...

    Authors: Arnd Gross, Anke Tönjes and Markus Scholz

    Citation: BMC Genetics 2017 18:104

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  6. Content type: Research article

    Clarifying genetic diversity in a large germplasm resource plays important roles in experimental designs that provides flexible utility in fundamental research and breeding in crops. However, the work is limit...

    Authors: Qijun Xu, Xingquan Zeng, Bin Lin, Zeqing Li, Hongjun Yuan, Yulin Wang, Zhasang and Nyima Tashi

    Citation: BMC Genetics 2017 18:102

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  7. Content type: Methodology article

    Breeding programs often rely on marker-assisted tests or variant calling of next generation sequence (NGS) data to identify regions of genomic introgression arising from the hybridization of two plant species....

    Authors: Daniel J. Shea, Motoki Shimizu, Namiko Nishida, Eigo Fukai, Takashi Abe, Ryo Fujimoto and Keiichi Okazaki

    Citation: BMC Genetics 2017 18:101

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  8. Content type: Research article

    Researchers have been exploring the molecular mechanisms underlying the control of periodontal ligament stem cell (PDLSC) osteogenic differentiation. Recently, long noncoding RNAs (lncRNAs) and circular RNAs (...

    Authors: Xiuge Gu, Mengying Li, Ye Jin, Dongxu Liu and Fulan Wei

    Citation: BMC Genetics 2017 18:100

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  9. Content type: Research article

    Current professional society guidelines recommend genetic carrier screening be offered on the basis of ethnicity, or when using expanded carrier screening panels, they recommend to compute residual risk based ...

    Authors: Roman Shraga, Sarah Yarnall, Sonya Elango, Arun Manoharan, Sally Ann Rodriguez, Sara L. Bristow, Neha Kumar, Mohammad Niknazar, David Hoffman, Shahin Ghadir, Rita Vassena, Serena H. Chen, Avner Hershlag, Jamie Grifo and Oscar Puig

    Citation: BMC Genetics 2017 18:99

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  10. Content type: Research article

    Populations of the earthworm, Lumbricus rubellus, are commonly found across highly contaminated former mine sites and are considered to have under-gone selection for mitigating metal toxicity. Comparison of adapt...

    Authors: Craig Anderson, Luis Cunha, Pierfrancesco Sechi, Peter Kille and David Spurgeon

    Citation: BMC Genetics 2017 18:97

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  11. Content type: Research article

    Assessment of genetic diversity of Vigna unguiculata (L.) Walp (cowpea) accessions using informative molecular markers is imperative for their genetic improvement and conservation. Use of efficacious molecular ma...

    Authors: David Okeh Igwe, Celestine Azubike Afiukwa, Benjamin Ewa Ubi, Kenneth Idika Ogbu, Omena Bernard Ojuederie and George Nkem Ude

    Citation: BMC Genetics 2017 18:98

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  12. Content type: Research article

    Ritodrine, a tocolytic β2-agonist, has been used extensively in Europe and Asia despite its safety concerns. This study was designed to identify associations between β2-adrenergic receptor (ADRB2) polymorphisms a...

    Authors: Jee Eun Chung, Soo An Choi, Han Sung Hwang, Jin Young Park, Kyung Eun Lee, Jeong Yee, Young Ju Kim and Hye Sun Gwak

    Citation: BMC Genetics 2017 18:96

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  13. Content type: Research article

    Crucian carp is a popular ornamental strain in Asia with variants in body color. To further explore the genetic mechanisms underlying gray and red body color formation in crucian carp, the skin transcriptomes ...

    Authors: Yongqin Zhang, Jinhui Liu, Wen Fu, Wenting Xu, Huiqin Zhang, Shujuan Chen, Wenbin Liu, Liangyue Peng and Yamei Xiao

    Citation: BMC Genetics 2017 18:95

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  14. Content type: Research article

    Seedling characteristics play significant roles in the growth and development of barley (Hordeum vulgare L.), including stable stand establishment, water and nutrients uptake, biotic resistance and abiotic stress...

    Authors: Qifei Wang, Genlou Sun, Xifeng Ren, Jibin Wang, Binbin Du, Chengdao Li and Dongfa Sun

    Citation: BMC Genetics 2017 18:94

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  15. Content type: Methodology article

    Undirected graphical models or Markov random fields have been a popular class of models for representing conditional dependence relationships between nodes. In particular, Markov networks help us to understand...

    Authors: Hosik Choi, Jungsoo Gim, Sungho Won, You Jin Kim, Sunghoon Kwon and Changyi Park

    Citation: BMC Genetics 2017 18:93

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  16. Content type: Research article

    Drosophila suzukii is a highly destructive pest species, causing substantial economic losses in soft fruit production. To better understand migration patterns, gene flow and adaptation...

    Authors: Gabriella Tait, Silvia Vezzulli, Fabiana Sassù, Gloria Antonini, Antonio Biondi, Nuray Baser, Giorgia Sollai, Alessandro Cini, Lorenzo Tonina, Lino Ometto and Gianfranco Anfora

    Citation: BMC Genetics 2017 18:87

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  17. Content type: Research article

    Sudan is endowed with a variety of indigenous goat breeds which are used for meat and milk production and which are well adapted to the local environment. The aim of the present study was to determine the gene...

    Authors: Siham A. Rahmatalla, Danny Arends, Monika Reissmann, Ammar Said Ahmed, Klaus Wimmers, Henry Reyer and Gudrun A. Brockmann

    Citation: BMC Genetics 2017 18:92

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  18. Content type: Methodology article

    For dichotomous traits, the generalized disequilibrium test with the moment estimate of the variance (GDT-ME) is a powerful family-based association method. Genomic imprinting is an important epigenetic phenom...

    Authors: Jian-Long Li, Peng Wang, Wing Kam Fung and Ji-Yuan Zhou

    Citation: BMC Genetics 2017 18:90

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  19. Content type: Research article

    Borassus flabellifer or Asian Palmyra palm is an important crop for local economies in the South and Southeast Asia for its fruit and palm sugar production. Archeological and historica...

    Authors: Kwanjai Pipatchartlearnwong, Akarapong Swatdipong, Supachai Vuttipongchaikij and Somsak Apisitwanich

    Citation: BMC Genetics 2017 18:88

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  20. Content type: Research article

    Previous studies in the Norwegian pig breeds Landrace and Duroc have revealed a QTL for levels of skatole located in the region 74.7–80.5 Mb on SSC7. Skatole is one of the main components causing boar taint, w...

    Authors: Maren van Son, Matthew P. Kent, Harald Grove, Rahul Agarwal, Hanne Hamland, Sigbjørn Lien and Eli Grindflek

    Citation: BMC Genetics 2017 18:85

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  21. Content type: Research article

    Allotetraploid F1 hybrids (4nF1) (AABB, 4n = 148) were generated from the distant hybridization of Carassius auratus red var. (RCC) (AA, 2n = 100) (♀) × Megalobrama amblycephala (BSB) (BB, 2n = 48) (♂). It has be...

    Authors: Y. D. Wang, Q. B. Qin, R. Yang, W. Z. Sun, Q. W. Liu, Y. Y. Huo, X. Huang, M. Tao, C. Zhang, T. Li and S. J. Liu

    Citation: BMC Genetics 2017 18:86

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  22. Content type: Research article

    Recent advances in the mapping of biochemical traits have been reported in Lolium perenne. Although the mapped traits, including individual sugars and fatty acids, contribute greatly towards ruminant productivity...

    Authors: Alexandre Foito, Christine Anne Hackett, Derek Stewart, Janaki Velmurugan, Dan Milbourne, Stephen L. Byrne and Susanne Barth

    Citation: BMC Genetics 2017 18:84

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  23. Content type: Software

    Inferring local ancestry in individuals of mixed ancestry has many applications, most notably in identifying disease-susceptible loci that vary among different ethnic groups. Many software packages are availab...

    Authors: Daniel Hui, Zhou Fang, Jerome Lin, Qing Duan, Yun Li, Ming Hu and Wei Chen

    Citation: BMC Genetics 2017 18:83

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  24. Content type: Research article

     Recent genetic studies based on genome-wide Single Nucleotide Polymorphism (SNP) data further investigated the history of Roma and suggested that the source of South Asian ancestry in Roma originates most lik...

    Authors: Bela I. Melegh, Zsolt Banfai, Kinga Hadzsiev, Attila Miseta and Bela Melegh

    Citation: BMC Genetics 2017 18:82

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  25. Content type: Research article

    Satellite DNAs (satDNAs) are organized in repetitions directly contiguous to one another, forming long arrays and composing a large portion of eukaryote genomes. These sequences evolve according to the concert...

    Authors: Diogo Milani, Érica Ramos, Vilma Loreto, Dardo Andrea Martí, Adauto Lima Cardoso, Karen Cristiane Martinez de Moraes, Cesar Martins and Diogo Cavalcanti Cabral-de-Mello

    Citation: BMC Genetics 2017 18:81

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  26. Content type: Research article

    Understanding the relationship between genetic admixture and performances is crucial for the success of crossbreeding programs. Use of small sets of ancestry informative markers (AIMs) is a cost effective opti...

    Authors: Tesfaye Getachew, Heather J. Huson, Maria Wurzinger, Jörg Burgstaller, Solomon Gizaw, Aynalem Haile, Barbara Rischkowsky, Gottfried Brem, Solomon Antwi Boison, Gábor Mészáros, Ally Okeyo Mwai and Johann Sölkner

    Citation: BMC Genetics 2017 18:80

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  27. Content type: Research article

    Seedling establishment is a crucial and vulnerable stage in the crop life cycle which determines further plant growth. While many studies are available on salt tolerance at the vegetative stage, the mechanisms...

    Authors: Wentao Xue, Jun Yan, Gang Zhao, Yan Jiang, Jianping Cheng, Luigi Cattivelli and Alessandro Tondelli

    Citation: BMC Genetics 2017 18:79

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  28. Content type: Research article

    Undernutrition is an increasingly common problem. Insufficient calorie intake and nutrient deficiencies during pregnancy may have an impact not only on the mother, but may also alter metabolism in the infant. ...

    Authors: Joanna Nowacka-Woszuk, Zofia E. Madeja and Agata Chmurzynska

    Citation: BMC Genetics 2017 18:78

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  29. Content type: Research article

    Understanding the molecular basis of insecticide resistance is key to improve the surveillance and monitoring of malaria vector populations under control. In the major malaria vector Anopheles funestus, little is...

    Authors: Helen Irving and Charles S. Wondji

    Citation: BMC Genetics 2017 18:76

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  30. Content type: Research article

    Misidentification of the chicken leptin gene has hampered research of leptin signaling in this species for almost two decades. Recently, the genuine leptin gene with a GC-rich (~70%) repetitive-sequence content w...

    Authors: Eyal Seroussi, Frédérique Pitel, Sophie Leroux, Mireille Morisson, Susanne Bornelöv, Shoval Miyara, Sara Yosefi, Larry A. Cogburn, David W. Burt, Leif Anderson and Miriam Friedman-Einat

    Citation: BMC Genetics 2017 18:77

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    The Correction to this article has been published in BMC Genetics 2017 18:113

  31. Content type: Research article

    The allotetraploid hybrid fish (4nAT) that was created in a previous study through an intergeneric cross between red crucian carp (Carassius auratus red var., ♀) and common carp (Cyprinus carpio L., ♂) provided a...

    Authors: Lihai Ye, Chun Zhang, Xiaojun Tang, Yiyi Chen and Shaojun Liu

    Citation: BMC Genetics 2017 18:75

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  32. Content type: Research article

    Surveillance for bovine genetic diseases in Denmark identified a hitherto unreported congenital syndrome occurring among progeny of a Holstein sire used for artificial breeding. A genetic aetiology due to a do...

    Authors: Jørgen S. Agerholm, Fintan J. McEvoy, Steffen Heegaard, Carole Charlier, Vidhya Jagannathan and Cord Drögemüller

    Citation: BMC Genetics 2017 18:74

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  33. Content type: Research article

    Korarima [Aframomum corrorima (Braun) P.C.M. Jansen] is a spice crop native to Ethiopia. Understanding the extent and partitioning of diversity within and among crop landraces and their wild relatives is among th...

    Authors: Dagmawit Chombe, Endashaw Bekele, Tomas Bryngelsson, Abel Teshome and Mulatu Geleta

    Citation: BMC Genetics 2017 18:72

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  34. Content type: Research article

    Persons living with HIV/AIDS (PLWHA) are at an increased risk of suicide. Increased suicidal risk is a predictor of future attempted and completed suicides and has been associated with poor quality of life and...

    Authors: Allan Kalungi, Soraya Seedat, Sian M. J. Hemmings, Lize van der Merwe, Moses L. Joloba, Ann Nanteza, Noeline Nakassujja, Harriet Birabwa, Jennifer Serwanga, Pontiano Kaleebu and Eugene Kinyanda

    Citation: BMC Genetics 2017 18:71

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  35. Content type: Methodology Article

    Genome-wide association studies involve detecting association between millions of genetic variants and a trait, which typically use univariate regression to test association between each single variant and the...

    Authors: Jaron Arbet, Matt McGue, Snigdhansu Chatterjee and Saonli Basu

    Citation: BMC Genetics 2017 18:70

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  36. Content type: Research article

    Neuregulin 3 (NRG3) plays a key role in central nervous system development and is a strong candidate for human mental disorders. Thus, genetic variation in NRG3 may have some impact on a variety of phenotypes in ...

    Authors: Hideaki Abe, Daiki Aoya, Hiro-aki Takeuchi and Miho Inoue-Murayama

    Citation: BMC Genetics 2017 18:69

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  37. Content type: Research article

    Investments in genetic selection have played a major role in the New Zealand sheep industry competitiveness. Selection may erode genetic diversity, which is a crucial factor for the success of breeding program...

    Authors: Vincent Prieur, Shannon M. Clarke, Luiz F. Brito, John C. McEwan, Michael A. Lee, Rudiger Brauning, Ken G. Dodds and Benoît Auvray

    Citation: BMC Genetics 2017 18:68

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  38. Content type: Research article

    The determinants of malaria parasite virulence is not entirely known, but the outcome of malaria infection (asymptomatic or symptomatic) has been associated with carriage of distinct parasite genotypes. Allele...

    Authors: Akua Kyerewaa Botwe, Kwaku Poku Asante, George Adjei, Samuel Assafuah, David Dosoo and Seth Owusu-Agyei

    Citation: BMC Genetics 2017 18:67

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  39. Content type: Research article

    Although Tellinidae is one of the largest and most diverse families of bivalves, its taxonomy is utterly chaotic. This is mainly due to the morphological diversity and homoplasy displayed by their shells and t...

    Authors: Daniel García-Souto, Gonzalo Ríos and Juan J. Pasantes

    Citation: BMC Genetics 2017 18:66

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  40. Content type: Research article

    Cowpea [Vigna unguiculata (L.) Walp.] is one of the most important legumes in tropical and semi-arid regions. However, there is relatively little genomic information available for genetic research on and breeding...

    Authors: Honglin Chen, Lixia Wang, Xiaoyan Liu, Liangliang Hu, Suhua Wang and Xuzhen Cheng

    Citation: BMC Genetics 2017 18:65

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  41. Content type: Research article

    Piglet splay leg syndrome (PSL) is one of the most frequent genetic defects, and can cause considerable economic loss in pig production. The present understanding of etiology and pathogenesis of PSL is poor. T...

    Authors: Xingjie Hao, Graham Plastow, Chunyan Zhang, Sutong Xu, Zhiqiu Hu, Tianfu Yang, Kai Wang, Huawei Yang, Xiaoxue Yin, Shili Liu, Zhenghua Wang, Zhiquan Wang and Shujun Zhang

    Citation: BMC Genetics 2017 18:64

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  42. Content type: Research article

    Using a genome-wide association study strategy, our previous study discovered 19 significant single-nucleotide polymorphisms (SNPs) related to semen production traits in Chinese Holstein bulls. Among them, thr...

    Authors: Shuli Liu, Hongwei Yin, Cong Li, Chunhua Qin, Wentao Cai, Mingyue Cao and Shengli Zhang

    Citation: BMC Genetics 2017 18:63

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  43. Content type: Research article

    Copy number variations are genome polymorphism that influence phenotypic variation and are an important source of genetic variation in populations. The aim of this study was to investigate genetic variability ...

    Authors: E. Gorla, M. C. Cozzi, S. I. Román-Ponce, F. J. Ruiz López, V. E. Vega-Murillo, S. Cerolini, A. Bagnato and M. G. Strillacci

    Citation: BMC Genetics 2017 18:61

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  44. Content type: Research article

    Genome-wide investigation of molecular mechanisms for high-altitude adaptation has attracted great attention in the last few years. In order to understand the contribution of gene expression level variations t...

    Authors: Weizhao Yang, Yin Qi, Bin Lu, Liang Qiao, Yayong Wu and Jinzhong Fu

    Citation: BMC Genetics 2017 18:62

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  45. Content type: Research article

    Cattle are bred for, amongst other factors, specific traits, including parasite resistance and adaptation to climate. However, the influence and inheritance of mitochondrial DNA (mtDNA) are not usually conside...

    Authors: Kanokwan Srirattana, Kieren McCosker, Tim Schatz and Justin C. St. John

    Citation: BMC Genetics 2017 18:59

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  46. Content type: Research article

    Circadian rhythms regulate key biological processes and the dysregulation of the intrinsic clock mechanism affects sleep patterns and obesity onset. The CLOCK (circadian locomotor output cycles protein kaput) gen...

    Authors: Pia Riestra, Samson Y Gebreab, Ruihua Xu, Rumana J Khan, Amadou Gaye, Adolfo Correa, Nancy Min, Mario Sims and Sharon K Davis

    Citation: BMC Genetics 2017 18:58

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