Figure 6From: Disentangling molecular relationships with a causal inference testType I error and power comparison between causality methods derived from computer simulated F2 mouse crosses. For each autosome of each replicate cross of N = 1000 total crosses, a clinical trait and potential mediating trait were simulated under a variety of true causal scenarios. For each scenario, a wide range of positive and negative effect sizes were randomly selected for each chromosome of each cross. 'Neighbors' denote chromosome-specific QTL peak pairs. Causal models are, causal (C), reactive (R), independent (I), hidden variable affecting both traits (H), and no associations between genotypes and traits (Null).Back to article page