Figure 1From: Novel mutations in the VKORC1 gene of wild rats and mice – a response to 50 years of selection pressure by warfarin?Relative VKOR activities of different rat VKORC1 variants after recombinant expression in HEK293 cells. Light grey bars indicate basal VKOR activities of the variants in the absence of warfarin; dark grey bars show VKOR activities after addition of 60 μM warfarin. The specific activity of the recombinant rat wild-type enzyme (WT) was 1.0 ± 0.37 nmoles/mg protein × h and was set to 100% for comparison. Standard deviations are indicated by black error bars.Back to article page