Figure 6

Interaction LOD score plots for the X - zone vacuolation grades for combined F ₂ mice. Horizontal dashed line indicates significant threshold LOD scores determined by 1,000 permutations. Solid lines denote the LOD scores when the four possible agouti genotypes (A/a, a/a, A^y/A, and A^y/a) were distinguished and included as covariates. Dotted lines denote the LOD scores when the two agouti genotypes (non-A^y or A^y) were distinguished and included as covariates.