Multilevel modeling for the analysis of longitudinal blood pressure data in the Framingham Heart Study pedigrees

BMC Genomic Data

Table 3 Results of two-point linkage analysis in the selected sample using residuals from the multilevel model (LOD scores ≥ 2 are in bold)

		Mean SBP Analysis adjusted for^A			SBP Slope Analysis adjusted for^A
Markers	Location	BMI, treatment	BMI only	Treatment only	BMI, treatment	BMI only	Treatment only
GATA48B01	1 (212 cM)	0.30	0.30	0.17	2.47	1.83	1.53
GATA11H10	2 (38 cM)	2.32	2.53	0.93	0.18	0.25	0
GATA6F06	3 (79 cM)	1.17	1.21	1.49	0.14	0.02	0.06
GATA4A10	3 (153 cM)	0.33	0.32	0.02	1.29	0.74	0.70
GATA72C10	8 (37 cM)	3.57	3.52	1.32	1.71	1.13	0.68
ATA34E08	11 (33 cM)	0.03	0.02	0.01	1.54	1.19	0.93
GATA7G10	13 (64 cM)	1.79	1.68	0.71	0	0	0
GATA25A04	17 (62 cM)	3.54	3.36	1.48	0	0	0

^AAll analyses are also adjusted for age effect in Level 1 and age, sex, and Cohort effects in Level 2.

ISSN: 2730-6844