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Table 2 Power to detect an association, one susceptibility site simulated and removed from the analysis

From: On the use of haplotype phylogeny to detect disease susceptibility loci

Tree

CT

CLADHC

HT

SbST

1

94.8 (3.8)

89.1 (3.5)

91.2 (5.6)

89.5 (3.9)

2

94.0 (3.8)

92.7 (4.1)

87.6 (5.6)

98.5 (5.3)

3

79.3 (3.2)

88.9 (4.7)

86.2 (4.7)

94.2 (4.1)

4

88.7 (2.3)

85.7 (3.1)

87.8 (4.6)

93.6 (4.4)

5

85.6 (4.3)

94.4 (4.1)

90.5 (4.5)

94.0 (4.1)

6

78.6 (3.0)

81.6 (3.3)

88.0 (4.2)

67.0 (4.2)

7

92.4 (3.8)

90.5 (3.7)

87.8 (5.2)

92.7 (4.0)

8

99.7 (3.0)

98.6 (2.8)

91.2 (4.7)

99.6 (4.5)

9

91.9 (3.7)

89.2 (4.5)

91.2 (4.8)

89.1 (4.1)

10

88.8 (2.9)

82.8 (3.0)

81.3 (4.1)

79.1 (3.5)

Average

89,38 (3.4)

89.35 (3.7)

88,28 (4.8)

89,73 (4.2)

Std dev.a

6.71 (0.6)

5.2 (0.6)

3.06 (0.5)

9.81 (0.5)

  1. Sample size: 100 cases and 100 controls, 1000 replicates, penetrance vector: [0.03;0.06;0.3], frequency of the susceptibility allele: 0.205 ± 0.005. The corresponding type I errors are indicated in italics within brackets. For each tree, the method giving the best result is underlined. CT: Cladistic Test, CLADHC: test developed by Durrant et al. [29], HT: Haplotypic Test, SbST: Site by Site Test.
  2. a Standard deviation