Genetic fixity in the human major histocompatibility complex and block size diversity in the class I region including HLA-E

Romero, Viviana; Larsen, Charles E; Duke-Cohan, Jonathan S; Fox, Edward A; Romero, Tatiana; Clavijo, Olga P; Fici, Dolores A; Husain, Zaheed; Almeciga, Ingrid; Alford, Dennis R; Awdeh, Zuheir L; Zuñiga, Joaquin; El-Dahdah, Lama; Alper, Chester A; Yunis, Edmond J

doi:10.1186/1471-2156-8-14

Table 1 Statistical analysis of HLA-A, -E, -Cw and -B haplotypes for Panel 1.

From: Genetic fixity in the human major histocompatibility complex and block size diversity in the class I region including HLA-E

I				II				III
HLA-A*	HLA-E*	f¹	P²	HLA-E*	HLA-Cw/B	f¹	P²	HLA-A*	HLA-E*	HLA-Cw/B	f¹	P²
*0101*	*0101*	95/432	< 1 × 10^-7	*0101*	*0701, 0801*	51/432	1.2 × 10^-6	*0101*	*0101*	*0701, 0801*	42/432	< 1 × 10^-7
					*0602, 5701*	14/432	ns			*0602, 5701*	10/432	5 × 10^-6
	*0101*	39/432	ns	*0101*	*0501, 4402*	13/432	ns		*0101*	*0501, 4402*	12/432	< 1 × 10^-7
*0201*					*07XX, 4402*	16/432	ns	*0201*		*07xx, 4402*	6/432	ns
	*010302*	28/432	0.0138	*010302*	*03xx, 40xx*	10/432	0.006		*010302*	*03xx, 40xx*	7/432	0.0001
*0301*	*010302*	30/432	3 × 10^-7	*010302*	*0702, 0702*	32/432	< 1 × 10^-7	*0301*	*010302*	*0702, 0702*	21/432	< 1 × 10^-7
	*010301*	13/432	0.00213
*1101*	*0101*	20/432	ns	*0101*	*0401, 3501*	36/432	ns	*0101*	*0101*	*0401, 3501*	6/432	ns
	*010301*	8/432	0.025	*010301*	*0602, 13XX*	6/432	0.0005		*010301*	*0602, 13xx*	3/432	ns
*2301*	*0101*	9/432	ns	*0101*	*08xx, 14xx*	11/432	ns	*2301*	*0101*	*08xx, 14xx*	1/432	ns
					*0401, 4403*	3/432	ns			*0401, 4403*	2/432	0.0154
*2402*	*0101*	31/432	ns	*0101*	*0401, 3501*	36/432	ns	*2402*	*0101*	*0401, 3501*	13/432	0.0008
	*010301*	8/432	ns	*010301*	*12xx, 5201*	2/432	ns		*010301*	*12xx, 5201*	2/432	ns
*24xx*	*010302*	16/432	ns	*010302*	*03xx, 15xx*	9/432	ns	*24xx*	*010302*	*03xx, 15xx*	4/432	ns
*2601*	*010301*	4/432	0.022	*010301*	*1203, 3801*	4/432	0.012	*2601*	*010301*	*1203, 3801*	4/432	2 × 10^-6
*2902*	*010302*	4/432	ns	*010302*	*1601, 4403*	3/432	ns	*2902*	*010302*	*1601, 4403*	2/432	0.005
*3001*	*010302*	2/432	ns	*010302*	*0501, 1801*	2/432	ns	*3001*	*010302*	*0501, 1801*	1/432	ns
*68xx*	*010302*	14/432	0.0183

¹Frequency (f)
²Probability (p)
Not significant (ns)

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