Table 7 Summary of average of two-gene genetic variance (mean) as the fraction of total phenotypic variance stratified into subpopulations by LCA.
The significance level for inclusion of cases corrected for multiple comparisons is 6.1E-06 | ||||||
|---|---|---|---|---|---|---|
Class | Average genetic variance | |||||
Minimum | Average | Maximum | Fraction | |||
Women | Total variance | 29 | 97 | 270 | ||
LCA/non-LCAa | 104 | 346 | 965 | |||
Additive variance | 9 | 29 | 78 | 29.6% | ||
LCA/non-LCA | 117 | 388 | 1,102 | |||
Dominant variance | 6 | 19 | 50 | 19.3% | ||
LCA/non-LCA | 104 | 332 | 864 | |||
Epistasis | 14 | 50 | 153 | 51.1% | ||
LCA/non-LCA | 105 | 378 | 1,143 | |||
Number of interactions | 2,188 | |||||
Fraction of possible | 26.5% | |||||
Number of interactions/trait | 156 | |||||
Men | Total variance | 39 | 97 | 430 | ||
LCA/non-LCA | 118 | 299 | 1,357 | |||
Additive variance | 9 | 29 | 118 | 30.0% | ||
LCA/non-LCA | 97 | 296 | 1,226 | |||
Dominant variance | 7 | 17 | 57 | 18.5% | ||
LCA/non-LCA | 102 | 270 | 857 | |||
Epistasis | 19 | 50 | 257 | 51.5% | ||
LCA/non-LCA | 124 | 329 | 1727 | |||
Number of interactions | 2,042 | |||||
Fraction of possible | 24,7% | |||||
Number of interactions/trait | 146 | |||||